TNF-a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection
Development of anaemia in inflammatory diseases is cytokine-mediated. Specifically, the levels of tumour necrosis factor-α (TNF-α), produced by activated macrophages, are correlated with severity of disease and anaemia in infections and chronic disease. In African trypanosomiasis, anaemia develops v...
| Autores principales: | , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
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Oxford University Press
2005
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| Acceso en línea: | https://hdl.handle.net/10568/1434 |
| _version_ | 1855519715613474816 |
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| author | Naessens, Jan Kitani, H. Nakamura, Y. Yagi, Y. Sekikawa, K. Iraqi, F.A. |
| author_browse | Iraqi, F.A. Kitani, H. Naessens, Jan Nakamura, Y. Sekikawa, K. Yagi, Y. |
| author_facet | Naessens, Jan Kitani, H. Nakamura, Y. Yagi, Y. Sekikawa, K. Iraqi, F.A. |
| author_sort | Naessens, Jan |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Development of anaemia in inflammatory diseases is cytokine-mediated. Specifically, the levels of tumour necrosis factor-α (TNF-α), produced by activated macrophages, are correlated with severity of disease and anaemia in infections and chronic disease. In African trypanosomiasis, anaemia develops very early in infection around the time when parasites become detectable in the blood. Since the anaemia persists after the first waves of parasitaemia when low numbers of trypanosomes are circulating in the blood, it is generally assumed that anaemia is not directly induced by a parasite factor, but might be cytokine-mediated, as in other cases of anaemia accompanying inflammation. To clarify the role of TNF-α in the development of anaemia, blood parameters of wild type (TNF-α+/+), TNF-α-null (TNF-α-/-) and TNF-α-hemizygous (TNF-α-/+) trypanotolerant mice were compared during infections with the cattle parasite Trypanosoma congolense. No differences in PCV, erythrocyte numbers or haemoglobin were observed between TNF-α-deficient and wild type mice, suggesting that the decrease in erythrocytes was not mediated by TNF-α. Erythropoetin (EPO) levels increased during infection and no significant differences in EPO levels were observed between the three mouse strains. In contrast, during an infection with the human pathogen Trypanosoma brucei rhodesiense, the number of red blood cells in TNF-α-deficient mice remained significantly higher than in the wild type mice. These data suggest that more than one mechanism promotes the development of anaemia associated with trypanosomiasis. |
| format | Journal Article |
| id | CGSpace1434 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2005 |
| publishDateRange | 2005 |
| publishDateSort | 2005 |
| publisher | Oxford University Press |
| publisherStr | Oxford University Press |
| record_format | dspace |
| spelling | CGSpace14342024-05-05T18:39:20Z TNF-a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection Naessens, Jan Kitani, H. Nakamura, Y. Yagi, Y. Sekikawa, K. Iraqi, F.A. trypanosomiasis disease control immunology trypanosoma brucei trypanosoma congolense infection anaemia cytokines Development of anaemia in inflammatory diseases is cytokine-mediated. Specifically, the levels of tumour necrosis factor-α (TNF-α), produced by activated macrophages, are correlated with severity of disease and anaemia in infections and chronic disease. In African trypanosomiasis, anaemia develops very early in infection around the time when parasites become detectable in the blood. Since the anaemia persists after the first waves of parasitaemia when low numbers of trypanosomes are circulating in the blood, it is generally assumed that anaemia is not directly induced by a parasite factor, but might be cytokine-mediated, as in other cases of anaemia accompanying inflammation. To clarify the role of TNF-α in the development of anaemia, blood parameters of wild type (TNF-α+/+), TNF-α-null (TNF-α-/-) and TNF-α-hemizygous (TNF-α-/+) trypanotolerant mice were compared during infections with the cattle parasite Trypanosoma congolense. No differences in PCV, erythrocyte numbers or haemoglobin were observed between TNF-α-deficient and wild type mice, suggesting that the decrease in erythrocytes was not mediated by TNF-α. Erythropoetin (EPO) levels increased during infection and no significant differences in EPO levels were observed between the three mouse strains. In contrast, during an infection with the human pathogen Trypanosoma brucei rhodesiense, the number of red blood cells in TNF-α-deficient mice remained significantly higher than in the wild type mice. These data suggest that more than one mechanism promotes the development of anaemia associated with trypanosomiasis. 2005-01-26 2010-05-09T19:14:46Z 2010-05-09T19:14:46Z Journal Article https://hdl.handle.net/10568/1434 en Open Access Oxford University Press Naessens, J., Kitani, H., Nakamura, Y., Yagi, Y., Sekikawa, K., & Iraqi, F. (2005). TNF-a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection. Clinical and Experimental Immunology, 139(3), 405–410. https://doi.org/10.1111/j.1365-2249.2004.02717.x |
| spellingShingle | trypanosomiasis disease control immunology trypanosoma brucei trypanosoma congolense infection anaemia cytokines Naessens, Jan Kitani, H. Nakamura, Y. Yagi, Y. Sekikawa, K. Iraqi, F.A. TNF-a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection |
| title | TNF-a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection |
| title_full | TNF-a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection |
| title_fullStr | TNF-a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection |
| title_full_unstemmed | TNF-a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection |
| title_short | TNF-a mediates the development of anaemia in a murine Trypanosoma brucei rhodesiense infection, but not the anaemia associated with a murine Trypanosoma congolense infection |
| title_sort | tnf a mediates the development of anaemia in a murine trypanosoma brucei rhodesiense infection but not the anaemia associated with a murine trypanosoma congolense infection |
| topic | trypanosomiasis disease control immunology trypanosoma brucei trypanosoma congolense infection anaemia cytokines |
| url | https://hdl.handle.net/10568/1434 |
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