Therapeutic effect of prolonged testosterone pretreatment in women with poor ovarian response: A randomized control trial
Purpose: This study compared the therapeutic effects of transdermal testosterone gel (TTG) application at 4 and 6 weeks before controlled ovarian hyperstimulation (COH) in women with poor ovarian response (POR). Methods: In this randomized control trial, infertile women with POR who underwent in vit...
| Main Authors: | , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
John Wiley & Sons
2021
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/142883 |
| _version_ | 1855539297802780672 |
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| author | Hoang, Quoc Huy Ho, Hung Sy Do, Huong Thuy Nguyen, Tien Viet Nguyen, Phuong Hong Le, Minh Tam |
| author_browse | Do, Huong Thuy Ho, Hung Sy Hoang, Quoc Huy Le, Minh Tam Nguyen, Phuong Hong Nguyen, Tien Viet |
| author_facet | Hoang, Quoc Huy Ho, Hung Sy Do, Huong Thuy Nguyen, Tien Viet Nguyen, Phuong Hong Le, Minh Tam |
| author_sort | Hoang, Quoc Huy |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Purpose: This study compared the therapeutic effects of transdermal testosterone gel (TTG) application at 4 and 6 weeks before controlled ovarian hyperstimulation (COH) in women with poor ovarian response (POR). Methods: In this randomized control trial, infertile women with POR who underwent in vitro fertilization (IVF) were recruited and randomly classified into 4 week (n = 42) and 6 week (n = 38) TTG treatment groups and control group (n = 42). The primary outcome was total number of retrieved mature oocytes. The secondary outcomes were the biochemical pregnancy rate, clinical pregnancy rate, and ongoing pregnancy rate. Results: No significant differences were observed in the number of oocytes retrieved, mature oocytes and embryos between all groups. Human chorionic gonadotropin (hCG) positive, clinical, and ongoing pregnancy rates were significantly higher in the TTG pretreatment groups than in the control group but no differences were observed between the 4‐ and 6 week groups. Conclusions: Applying TTG in infertile women with POR may ameliorate the outcomes of IVF. The extended application of TTG to 6 weeks did not improve the response to ovarian stimulation regarding the number of retrieved oocytes nor pregnancy outcomes compared to the 4 week pretreatment. |
| format | Journal Article |
| id | CGSpace142883 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | John Wiley & Sons |
| publisherStr | John Wiley & Sons |
| record_format | dspace |
| spelling | CGSpace1428832025-04-03T21:29:14Z Therapeutic effect of prolonged testosterone pretreatment in women with poor ovarian response: A randomized control trial Hoang, Quoc Huy Ho, Hung Sy Do, Huong Thuy Nguyen, Tien Viet Nguyen, Phuong Hong Le, Minh Tam testosterone ovaries drugs pregnancy poor ovarian response infertility reproductive disorders female infertility in vitro fertilization ova reproduction Purpose: This study compared the therapeutic effects of transdermal testosterone gel (TTG) application at 4 and 6 weeks before controlled ovarian hyperstimulation (COH) in women with poor ovarian response (POR). Methods: In this randomized control trial, infertile women with POR who underwent in vitro fertilization (IVF) were recruited and randomly classified into 4 week (n = 42) and 6 week (n = 38) TTG treatment groups and control group (n = 42). The primary outcome was total number of retrieved mature oocytes. The secondary outcomes were the biochemical pregnancy rate, clinical pregnancy rate, and ongoing pregnancy rate. Results: No significant differences were observed in the number of oocytes retrieved, mature oocytes and embryos between all groups. Human chorionic gonadotropin (hCG) positive, clinical, and ongoing pregnancy rates were significantly higher in the TTG pretreatment groups than in the control group but no differences were observed between the 4‐ and 6 week groups. Conclusions: Applying TTG in infertile women with POR may ameliorate the outcomes of IVF. The extended application of TTG to 6 weeks did not improve the response to ovarian stimulation regarding the number of retrieved oocytes nor pregnancy outcomes compared to the 4 week pretreatment. 2021-07-01 2024-05-22T12:11:14Z 2024-05-22T12:11:14Z Journal Article https://hdl.handle.net/10568/142883 en Open Access John Wiley & Sons Hoang, Quoc Huy; Ho, Hung Sy; Do, Huong Thuy; Nguyen, Tien Viet; Nguyen, Phuong Hong; and Le, Minh Tam. 2021. Therapeutic effect of prolonged testosterone pretreatment in women with poor ovarian response: A randomized control trial. Reproductive Medicine and Biology 20(3): 305-312. https://doi.org/10.1002/rmb2.12383 |
| spellingShingle | testosterone ovaries drugs pregnancy poor ovarian response infertility reproductive disorders female infertility in vitro fertilization ova reproduction Hoang, Quoc Huy Ho, Hung Sy Do, Huong Thuy Nguyen, Tien Viet Nguyen, Phuong Hong Le, Minh Tam Therapeutic effect of prolonged testosterone pretreatment in women with poor ovarian response: A randomized control trial |
| title | Therapeutic effect of prolonged testosterone pretreatment in women with poor ovarian response: A randomized control trial |
| title_full | Therapeutic effect of prolonged testosterone pretreatment in women with poor ovarian response: A randomized control trial |
| title_fullStr | Therapeutic effect of prolonged testosterone pretreatment in women with poor ovarian response: A randomized control trial |
| title_full_unstemmed | Therapeutic effect of prolonged testosterone pretreatment in women with poor ovarian response: A randomized control trial |
| title_short | Therapeutic effect of prolonged testosterone pretreatment in women with poor ovarian response: A randomized control trial |
| title_sort | therapeutic effect of prolonged testosterone pretreatment in women with poor ovarian response a randomized control trial |
| topic | testosterone ovaries drugs pregnancy poor ovarian response infertility reproductive disorders female infertility in vitro fertilization ova reproduction |
| url | https://hdl.handle.net/10568/142883 |
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