Daily consumption of pro-vitamin A biofortified (yellow) cassava improves serum retinol concentrations in preschool children in Nigeria: A randomized controlled trial
Background: Vitamin A deficiency is a public health problem in sub-Saharan Africa. Pro-vitamin A biofortified (yellow) cassava has the potential to contribute significantly to improve vitamin A status, especially in populations that are difficult to reach with other strategies. Objectives: The study...
| Autores principales: | , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
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American Society for Nutrition
2021
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| Acceso en línea: | https://hdl.handle.net/10568/142332 |
| _version_ | 1855538578762760192 |
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| author | Afolami, Ibukun Mwangi, Martin N. Samuel, Folake Boy, Erick Ilona, Paul Talsma, Elise F. Feskens, Edith J. M. Melse-Boonstra, Alida |
| author_browse | Afolami, Ibukun Boy, Erick Feskens, Edith J. M. Ilona, Paul Melse-Boonstra, Alida Mwangi, Martin N. Samuel, Folake Talsma, Elise F. |
| author_facet | Afolami, Ibukun Mwangi, Martin N. Samuel, Folake Boy, Erick Ilona, Paul Talsma, Elise F. Feskens, Edith J. M. Melse-Boonstra, Alida |
| author_sort | Afolami, Ibukun |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Background: Vitamin A deficiency is a public health problem in sub-Saharan Africa. Pro-vitamin A biofortified (yellow) cassava has the potential to contribute significantly to improve vitamin A status, especially in populations that are difficult to reach with other strategies. Objectives: The study aimed at determining the efficacy of biofortified cassava to improve vitamin A status of Nigerian preschool children. Methods: An open-label randomized controlled trial was conducted in southwestern Nigeria. In total, 176 preschool children (aged 3–5 y) were randomized into 2 parallel arms comprising an experimental group (n = 88), fed foods prepared from biofortified (yellow) cassava, and a control group (n = 88), fed foods prepared from white cassava, twice a day, 6 d a week for 93 d. Results: A total of 159 children completed the trial (yellow cassava group, n = 80; white cassava group, n = 79). Children consumed 221 and 74 µg/d retinol activity equivalents from intervention foods in the yellow and white cassava groups, respectively. The treatment effect on serum retinol concentrations at the end of the feeding trial was 0.06 µmol/L (95% CI: 0.004, 0.124 µmol/L), after adjustment for baseline retinol concentrations, inflammation, and asymptomatic malaria status. No significant treatment effects were detected for serum β-carotene (adjusted effect: 3.9%; 95% CI: −0.6%, 8.6%) and gut permeability (adjusted effect: 0.002; 95% CI: −0.089, 0.092), but a significant effect was detected for hemoglobin concentrations (adjusted effect: 3.08 g/L; 95% CI: 0.38, 5.78 g/L). Conclusions: Daily consumption of β-carotene from biofortified cassava improved serum retinol and hemoglobin concentrations modestly in Nigerian preschool children. This study was registered with clinicaltrials.gov as NCT02627222. |
| format | Journal Article |
| id | CGSpace142332 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | American Society for Nutrition |
| publisherStr | American Society for Nutrition |
| record_format | dspace |
| spelling | CGSpace1423322025-02-24T06:48:58Z Daily consumption of pro-vitamin A biofortified (yellow) cassava improves serum retinol concentrations in preschool children in Nigeria: A randomized controlled trial Afolami, Ibukun Mwangi, Martin N. Samuel, Folake Boy, Erick Ilona, Paul Talsma, Elise F. Feskens, Edith J. M. Melse-Boonstra, Alida biofortification health consumption vitamin a deficiency randomized controlled trials provitamins capacity development retinol preschool children nutrition children cassava Background: Vitamin A deficiency is a public health problem in sub-Saharan Africa. Pro-vitamin A biofortified (yellow) cassava has the potential to contribute significantly to improve vitamin A status, especially in populations that are difficult to reach with other strategies. Objectives: The study aimed at determining the efficacy of biofortified cassava to improve vitamin A status of Nigerian preschool children. Methods: An open-label randomized controlled trial was conducted in southwestern Nigeria. In total, 176 preschool children (aged 3–5 y) were randomized into 2 parallel arms comprising an experimental group (n = 88), fed foods prepared from biofortified (yellow) cassava, and a control group (n = 88), fed foods prepared from white cassava, twice a day, 6 d a week for 93 d. Results: A total of 159 children completed the trial (yellow cassava group, n = 80; white cassava group, n = 79). Children consumed 221 and 74 µg/d retinol activity equivalents from intervention foods in the yellow and white cassava groups, respectively. The treatment effect on serum retinol concentrations at the end of the feeding trial was 0.06 µmol/L (95% CI: 0.004, 0.124 µmol/L), after adjustment for baseline retinol concentrations, inflammation, and asymptomatic malaria status. No significant treatment effects were detected for serum β-carotene (adjusted effect: 3.9%; 95% CI: −0.6%, 8.6%) and gut permeability (adjusted effect: 0.002; 95% CI: −0.089, 0.092), but a significant effect was detected for hemoglobin concentrations (adjusted effect: 3.08 g/L; 95% CI: 0.38, 5.78 g/L). Conclusions: Daily consumption of β-carotene from biofortified cassava improved serum retinol and hemoglobin concentrations modestly in Nigerian preschool children. This study was registered with clinicaltrials.gov as NCT02627222. 2021-01-01 2024-05-22T12:10:20Z 2024-05-22T12:10:20Z Journal Article https://hdl.handle.net/10568/142332 en https://doi.org/10.3945/ajcn.114.100164 Open Access American Society for Nutrition Afolami, Ibukun; Mwangi, Martin N.; Samuel, Folake; Boy, Erick; Ilona, Paul; Talsma, Elise F.; Feskens, Edith J.; and Melse-Boonstra, Alida. 2021. Daily consumption of pro-vitamin A biofortified (yellow) cassava improves serum retinol concentrations in preschool children in Nigeria: A randomized controlled trial. American Journal of Clinical Nutrition 113(1): 221–231. https://doi.org/10.1093/ajcn/nqaa290 |
| spellingShingle | biofortification health consumption vitamin a deficiency randomized controlled trials provitamins capacity development retinol preschool children nutrition children cassava Afolami, Ibukun Mwangi, Martin N. Samuel, Folake Boy, Erick Ilona, Paul Talsma, Elise F. Feskens, Edith J. M. Melse-Boonstra, Alida Daily consumption of pro-vitamin A biofortified (yellow) cassava improves serum retinol concentrations in preschool children in Nigeria: A randomized controlled trial |
| title | Daily consumption of pro-vitamin A biofortified (yellow) cassava improves serum retinol concentrations in preschool children in Nigeria: A randomized controlled trial |
| title_full | Daily consumption of pro-vitamin A biofortified (yellow) cassava improves serum retinol concentrations in preschool children in Nigeria: A randomized controlled trial |
| title_fullStr | Daily consumption of pro-vitamin A biofortified (yellow) cassava improves serum retinol concentrations in preschool children in Nigeria: A randomized controlled trial |
| title_full_unstemmed | Daily consumption of pro-vitamin A biofortified (yellow) cassava improves serum retinol concentrations in preschool children in Nigeria: A randomized controlled trial |
| title_short | Daily consumption of pro-vitamin A biofortified (yellow) cassava improves serum retinol concentrations in preschool children in Nigeria: A randomized controlled trial |
| title_sort | daily consumption of pro vitamin a biofortified yellow cassava improves serum retinol concentrations in preschool children in nigeria a randomized controlled trial |
| topic | biofortification health consumption vitamin a deficiency randomized controlled trials provitamins capacity development retinol preschool children nutrition children cassava |
| url | https://hdl.handle.net/10568/142332 |
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