Small-quantity lipid-based nutrient supplements for children age 6-24 months: A systematic review and individual participant data meta-analysis of effects on developmental outcomes and effect modifiers
Background Small-quantity (SQ) lipid-based nutrient supplements (LNSs) provide many nutrients needed for brain development. Objectives We aimed to generate pooled estimates of the effect of SQ-LNSs on developmental outcomes (language, social-emotional, motor, and executive function), and to identify...
| Autores principales: | , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
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American Society for Nutrition
2021
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| Acceso en línea: | https://hdl.handle.net/10568/142331 |
| _version_ | 1855518222923595776 |
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| author | Prado, Elizabeth L. Arnold, Charles D. Wessells, K. Ryan Stewart, Christine P. Abbeddou, Souheila Adu-Afarwuah, Seth Arnold, Benjamin F. Becquey, Elodie Huybregts, Lieven |
| author_browse | Abbeddou, Souheila Adu-Afarwuah, Seth Arnold, Benjamin F. Arnold, Charles D. Becquey, Elodie Huybregts, Lieven Prado, Elizabeth L. Stewart, Christine P. Wessells, K. Ryan |
| author_facet | Prado, Elizabeth L. Arnold, Charles D. Wessells, K. Ryan Stewart, Christine P. Abbeddou, Souheila Adu-Afarwuah, Seth Arnold, Benjamin F. Becquey, Elodie Huybregts, Lieven |
| author_sort | Prado, Elizabeth L. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Background Small-quantity (SQ) lipid-based nutrient supplements (LNSs) provide many nutrients needed for brain development. Objectives We aimed to generate pooled estimates of the effect of SQ-LNSs on developmental outcomes (language, social-emotional, motor, and executive function), and to identify study-level and individual-level modifiers of these effects. Methods We conducted a 2-stage meta-analysis of individual participant data from 14 intervention against control group comparisons in 13 randomized trials of SQ-LNSs provided to children age 6–24 mo (total n = 30,024). Results In 11–13 intervention against control group comparisons (n = 23,588–24,561), SQ-LNSs increased mean language (mean difference: 0.07 SD; 95% CI: 0.04, 0.10 SD), social-emotional (0.08; 0.05, 0.11 SD), and motor scores (0.08; 95% CI: 0.05, 0.11 SD) and reduced the prevalence of children in the lowest decile of these scores by 16% (prevalence ratio: 0.84; 95% CI: 0.76, 0.92), 19% (0.81; 95% CI: 0.74, 0.89), and 16% (0.84; 95% CI: 0.76, 0.92), respectively. SQ-LNSs also increased the prevalence of children walking without support at 12 mo by 9% (1.09; 95% CI: 1.05, 1.14). Effects of SQ-LNSs on language, social-emotional, and motor outcomes were larger among study populations with a higher stunting burden (≥35%) (mean difference: 0.11–0.13 SD; 8–9 comparisons). At the individual level, greater effects of SQ-LNSs were found on language among children who were acutely malnourished (mean difference: 0.31) at baseline; on language (0.12), motor (0.11), and executive function (0.06) among children in households with lower socioeconomic status; and on motor development among later-born children (0.11), children of older mothers (0.10), and children of mothers with lower education (0.11). Conclusions Child SQ-LNSs can be expected to result in modest developmental gains, which would be analogous to 1–1.5 IQ points on an IQ test, particularly in populations with a high child stunting burden. Certain groups of children who experience higher-risk environments have greater potential to benefit from SQ-LNSs in developmental outcomes. |
| format | Journal Article |
| id | CGSpace142331 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | American Society for Nutrition |
| publisherStr | American Society for Nutrition |
| record_format | dspace |
| spelling | CGSpace1423312025-02-24T06:47:42Z Small-quantity lipid-based nutrient supplements for children age 6-24 months: A systematic review and individual participant data meta-analysis of effects on developmental outcomes and effect modifiers Prado, Elizabeth L. Arnold, Charles D. Wessells, K. Ryan Stewart, Christine P. Abbeddou, Souheila Adu-Afarwuah, Seth Arnold, Benjamin F. Becquey, Elodie Huybregts, Lieven maternal and child health lipids food supplements child nutrition child development stunting nutrients malnutrition supplements nutrition trace elements feeding Background Small-quantity (SQ) lipid-based nutrient supplements (LNSs) provide many nutrients needed for brain development. Objectives We aimed to generate pooled estimates of the effect of SQ-LNSs on developmental outcomes (language, social-emotional, motor, and executive function), and to identify study-level and individual-level modifiers of these effects. Methods We conducted a 2-stage meta-analysis of individual participant data from 14 intervention against control group comparisons in 13 randomized trials of SQ-LNSs provided to children age 6–24 mo (total n = 30,024). Results In 11–13 intervention against control group comparisons (n = 23,588–24,561), SQ-LNSs increased mean language (mean difference: 0.07 SD; 95% CI: 0.04, 0.10 SD), social-emotional (0.08; 0.05, 0.11 SD), and motor scores (0.08; 95% CI: 0.05, 0.11 SD) and reduced the prevalence of children in the lowest decile of these scores by 16% (prevalence ratio: 0.84; 95% CI: 0.76, 0.92), 19% (0.81; 95% CI: 0.74, 0.89), and 16% (0.84; 95% CI: 0.76, 0.92), respectively. SQ-LNSs also increased the prevalence of children walking without support at 12 mo by 9% (1.09; 95% CI: 1.05, 1.14). Effects of SQ-LNSs on language, social-emotional, and motor outcomes were larger among study populations with a higher stunting burden (≥35%) (mean difference: 0.11–0.13 SD; 8–9 comparisons). At the individual level, greater effects of SQ-LNSs were found on language among children who were acutely malnourished (mean difference: 0.31) at baseline; on language (0.12), motor (0.11), and executive function (0.06) among children in households with lower socioeconomic status; and on motor development among later-born children (0.11), children of older mothers (0.10), and children of mothers with lower education (0.11). Conclusions Child SQ-LNSs can be expected to result in modest developmental gains, which would be analogous to 1–1.5 IQ points on an IQ test, particularly in populations with a high child stunting burden. Certain groups of children who experience higher-risk environments have greater potential to benefit from SQ-LNSs in developmental outcomes. 2021-11-01 2024-05-22T12:10:20Z 2024-05-22T12:10:20Z Journal Article https://hdl.handle.net/10568/142331 en https://doi.org/10.1186/s12889-017-4146-6 https://doi.org/10.1371/journal.pmed.1002892 Open Access American Society for Nutrition Prado, Elizabeth L.; Arnold, Charles D.; Wessells, K. Ryan; Stewart, Christine P.; Abbeddou, Souheila; Adu-Afarwuah, Seth; Arnold, Benjamin F.; Becquey, Elodie; Huybregts, Lieven; et al. 2021. Small-quantity lipid-based nutrient supplements for children age 6-24 months: A systematic review and individual participant data meta-analysis of effects on developmental outcomes and effect modifiers. American Journal of Clinical Nutrition 114(Supplement 1): 43S-67S. https://doi.org/10.1093/ajcn/nqab277 |
| spellingShingle | maternal and child health lipids food supplements child nutrition child development stunting nutrients malnutrition supplements nutrition trace elements feeding Prado, Elizabeth L. Arnold, Charles D. Wessells, K. Ryan Stewart, Christine P. Abbeddou, Souheila Adu-Afarwuah, Seth Arnold, Benjamin F. Becquey, Elodie Huybregts, Lieven Small-quantity lipid-based nutrient supplements for children age 6-24 months: A systematic review and individual participant data meta-analysis of effects on developmental outcomes and effect modifiers |
| title | Small-quantity lipid-based nutrient supplements for children age 6-24 months: A systematic review and individual participant data meta-analysis of effects on developmental outcomes and effect modifiers |
| title_full | Small-quantity lipid-based nutrient supplements for children age 6-24 months: A systematic review and individual participant data meta-analysis of effects on developmental outcomes and effect modifiers |
| title_fullStr | Small-quantity lipid-based nutrient supplements for children age 6-24 months: A systematic review and individual participant data meta-analysis of effects on developmental outcomes and effect modifiers |
| title_full_unstemmed | Small-quantity lipid-based nutrient supplements for children age 6-24 months: A systematic review and individual participant data meta-analysis of effects on developmental outcomes and effect modifiers |
| title_short | Small-quantity lipid-based nutrient supplements for children age 6-24 months: A systematic review and individual participant data meta-analysis of effects on developmental outcomes and effect modifiers |
| title_sort | small quantity lipid based nutrient supplements for children age 6 24 months a systematic review and individual participant data meta analysis of effects on developmental outcomes and effect modifiers |
| topic | maternal and child health lipids food supplements child nutrition child development stunting nutrients malnutrition supplements nutrition trace elements feeding |
| url | https://hdl.handle.net/10568/142331 |
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