Effects of dose and duration of zinc interventions on risk factors for Type 2 Diabetes and Cardiovascular Disease: A systematic review and meta-analysis
No meta-analysis has examined the effect of dose and duration of zinc interventions on their impact on risk factors for type 2 diabetes (T2D) or cardiovascular disease (CVD). This study aimed first to compare the effects of zinc interventions dichotomized as low versus high dose (<25 mg/d and ≥25...
| Autores principales: | , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
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American Society for Nutrition
2021
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| Acceso en línea: | https://hdl.handle.net/10568/142263 |
| _version_ | 1855516375388258304 |
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| author | Pompano, Laura M. Boy, Erick |
| author_browse | Boy, Erick Pompano, Laura M. |
| author_facet | Pompano, Laura M. Boy, Erick |
| author_sort | Pompano, Laura M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | No meta-analysis has examined the effect of dose and duration of zinc interventions on their impact on risk factors for type 2 diabetes (T2D) or cardiovascular disease (CVD). This study aimed first to compare the effects of zinc interventions dichotomized as low versus high dose (<25 mg/d and ≥25 mg/d, respectively) and short versus long duration (<12 wk and ≥12 wk, respectively) on risk factors for T2D and CVD. Second, it discusses the results from the low-dose and long-duration meta-analyses as a foundation for understanding what impact a zinc-biofortification intervention could have on these risk factors. The PubMed and Cochrane Review databases were searched through January 2020 for full-text, human studies providing zinc supplements (alone) at doses ≤75 mg/d and a placebo. Data on study and sample characteristics and several T2D and CVD risk factors were extracted. There were 1042 and 974 participants receiving zinc and placebo, respectively, from 27 studies. Low-dose zinc supplementation (<25 mg/d) significantly benefited fasting blood glucose, insulin resistance, triglycerides, total cholesterol, and LDL cholesterol. High-dose zinc supplementation (≥25 mg/d) benefited glycated hemoglobin and insulin resistance. Short-duration interventions (<12 wk) benefited fasting blood glucose, insulin resistance, and triglycerides, while long-duration studies (≥12 wk) benefited fasting blood glucose, triglycerides, and total and LDL cholesterol. Effect sizes for low-dose and long-duration interventions were of equal or greater magnitude to those from high-dose or short-duration interventions. Low-dose and long-duration zinc supplementation each improved more risk factors for T2D and CVD than high-dose and short-duration interventions, respectively. It is currently unknown whether low doses of zinc delivered over long durations via a biofortified crop would similarly impact these risk factors. However, this review suggests that low-dose, long-duration zinc intake from supplements, and potentially biofortification, can benefit risk factors for T2D and CVD. |
| format | Journal Article |
| id | CGSpace142263 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | American Society for Nutrition |
| publisherStr | American Society for Nutrition |
| record_format | dspace |
| spelling | CGSpace1422632024-10-25T07:53:50Z Effects of dose and duration of zinc interventions on risk factors for Type 2 Diabetes and Cardiovascular Disease: A systematic review and meta-analysis Pompano, Laura M. Boy, Erick dosage biofortification non-communicable diseases health cardiovascular diseases food supplementation chronic course risk zinc diabetes fortification No meta-analysis has examined the effect of dose and duration of zinc interventions on their impact on risk factors for type 2 diabetes (T2D) or cardiovascular disease (CVD). This study aimed first to compare the effects of zinc interventions dichotomized as low versus high dose (<25 mg/d and ≥25 mg/d, respectively) and short versus long duration (<12 wk and ≥12 wk, respectively) on risk factors for T2D and CVD. Second, it discusses the results from the low-dose and long-duration meta-analyses as a foundation for understanding what impact a zinc-biofortification intervention could have on these risk factors. The PubMed and Cochrane Review databases were searched through January 2020 for full-text, human studies providing zinc supplements (alone) at doses ≤75 mg/d and a placebo. Data on study and sample characteristics and several T2D and CVD risk factors were extracted. There were 1042 and 974 participants receiving zinc and placebo, respectively, from 27 studies. Low-dose zinc supplementation (<25 mg/d) significantly benefited fasting blood glucose, insulin resistance, triglycerides, total cholesterol, and LDL cholesterol. High-dose zinc supplementation (≥25 mg/d) benefited glycated hemoglobin and insulin resistance. Short-duration interventions (<12 wk) benefited fasting blood glucose, insulin resistance, and triglycerides, while long-duration studies (≥12 wk) benefited fasting blood glucose, triglycerides, and total and LDL cholesterol. Effect sizes for low-dose and long-duration interventions were of equal or greater magnitude to those from high-dose or short-duration interventions. Low-dose and long-duration zinc supplementation each improved more risk factors for T2D and CVD than high-dose and short-duration interventions, respectively. It is currently unknown whether low doses of zinc delivered over long durations via a biofortified crop would similarly impact these risk factors. However, this review suggests that low-dose, long-duration zinc intake from supplements, and potentially biofortification, can benefit risk factors for T2D and CVD. 2021-01-01 2024-05-22T12:10:14Z 2024-05-22T12:10:14Z Journal Article https://hdl.handle.net/10568/142263 en Open Access American Society for Nutrition Pompano, Laura M.; and Boy, Erick. 2021. Effects of dose and duration of zinc interventions on risk factors for Type 2 Diabetes and Cardiovascular Disease: A systematic review and meta-analysis. Advances in Nutrition 12(1): 141–160. https://doi.org/10.1093/advances/nmaa087 |
| spellingShingle | dosage biofortification non-communicable diseases health cardiovascular diseases food supplementation chronic course risk zinc diabetes fortification Pompano, Laura M. Boy, Erick Effects of dose and duration of zinc interventions on risk factors for Type 2 Diabetes and Cardiovascular Disease: A systematic review and meta-analysis |
| title | Effects of dose and duration of zinc interventions on risk factors for Type 2 Diabetes and Cardiovascular Disease: A systematic review and meta-analysis |
| title_full | Effects of dose and duration of zinc interventions on risk factors for Type 2 Diabetes and Cardiovascular Disease: A systematic review and meta-analysis |
| title_fullStr | Effects of dose and duration of zinc interventions on risk factors for Type 2 Diabetes and Cardiovascular Disease: A systematic review and meta-analysis |
| title_full_unstemmed | Effects of dose and duration of zinc interventions on risk factors for Type 2 Diabetes and Cardiovascular Disease: A systematic review and meta-analysis |
| title_short | Effects of dose and duration of zinc interventions on risk factors for Type 2 Diabetes and Cardiovascular Disease: A systematic review and meta-analysis |
| title_sort | effects of dose and duration of zinc interventions on risk factors for type 2 diabetes and cardiovascular disease a systematic review and meta analysis |
| topic | dosage biofortification non-communicable diseases health cardiovascular diseases food supplementation chronic course risk zinc diabetes fortification |
| url | https://hdl.handle.net/10568/142263 |
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