Characteristics and birth outcomes of pregnant adolescents compared to older women: An analysis of individual level data from 140,000 mothers from 20 RCTs
Background: Adolescence is a critical period of maturation when nutrient needs are high, especially among adolescents entering pregnancy. Using individual-level data from 140,000 participants, we examined socioeconomic, nutrition, and pregnancy and birth outcomes for adolescent mothers (10–19 years)...
| Autores principales: | , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/141379 |
| _version_ | 1855522122537893888 |
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| author | Akseer, Nadia Keats, Emily Catherine Thurairajah, Pravheen Cousens, Simon N. Betran, Ana Pilar Oaks, Brietta M. Huybregts, Lieven |
| author_browse | Akseer, Nadia Betran, Ana Pilar Cousens, Simon N. Huybregts, Lieven Keats, Emily Catherine Oaks, Brietta M. Thurairajah, Pravheen |
| author_facet | Akseer, Nadia Keats, Emily Catherine Thurairajah, Pravheen Cousens, Simon N. Betran, Ana Pilar Oaks, Brietta M. Huybregts, Lieven |
| author_sort | Akseer, Nadia |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Background: Adolescence is a critical period of maturation when nutrient needs are high, especially among adolescents entering pregnancy. Using individual-level data from 140,000 participants, we examined socioeconomic, nutrition, and pregnancy and birth outcomes for adolescent mothers (10–19 years) compared to older mothers in low and middle-income countries. Methods: This study was conducted between March 16, 2018 and May 25, 2021. Data were obtained from 20 randomised controlled trials of micronutrient supplementation in pregnancy. Stratified analyses were conducted by age (10–14 years, 15–17 years, 18–19 years, 20–29 years, 30–39 years, 40+ years) and geographical region (Africa, Asia). Crude and confounder-adjusted means, prevalence and relative risks of pregnancy, nutrition and birth outcomes were estimated using multivariable linear and log-binomial regression models with 95% confidence intervals. Findings: Adolescent mothers comprised 31.6% of our data. Preterm birth, small-for-gestational age (SGA), low birthweight (LBW) and newborn mortality followed a U-shaped trend in which prevalence was highest among the youngest mothers (10–14 years) and then reduced gradually, but increased again for older mothers (40+ years). When compared to mothers aged 20–29 years, there was a 23% increased risk of preterm birth, a 60% increased risk of perinatal mortality, a 63% increased risk of neonatal mortality, a 28% increased risk of LBW, and a 22% increased risk of SGA among mothers 10–14 years. Mothers 40+ years experienced a 22% increased risk of preterm birth and a 103% increased risk of stillbirth when compared to the 20–29 year group. Interpretation: The youngest and oldest mothers suffer most from adverse pregnancy and birth outcomes. Policy and programming agendas should consider both biological and socioeconomic/environmental factors when targeting these populations. |
| format | Journal Article |
| id | CGSpace141379 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace1413792025-10-26T13:01:34Z Characteristics and birth outcomes of pregnant adolescents compared to older women: An analysis of individual level data from 140,000 mothers from 20 RCTs Akseer, Nadia Keats, Emily Catherine Thurairajah, Pravheen Cousens, Simon N. Betran, Ana Pilar Oaks, Brietta M. Huybregts, Lieven maternal and child health nutritional status determinants prematurity adolescents pregnant adolescents pregnancy reproductive health pregnancy complications age Background: Adolescence is a critical period of maturation when nutrient needs are high, especially among adolescents entering pregnancy. Using individual-level data from 140,000 participants, we examined socioeconomic, nutrition, and pregnancy and birth outcomes for adolescent mothers (10–19 years) compared to older mothers in low and middle-income countries. Methods: This study was conducted between March 16, 2018 and May 25, 2021. Data were obtained from 20 randomised controlled trials of micronutrient supplementation in pregnancy. Stratified analyses were conducted by age (10–14 years, 15–17 years, 18–19 years, 20–29 years, 30–39 years, 40+ years) and geographical region (Africa, Asia). Crude and confounder-adjusted means, prevalence and relative risks of pregnancy, nutrition and birth outcomes were estimated using multivariable linear and log-binomial regression models with 95% confidence intervals. Findings: Adolescent mothers comprised 31.6% of our data. Preterm birth, small-for-gestational age (SGA), low birthweight (LBW) and newborn mortality followed a U-shaped trend in which prevalence was highest among the youngest mothers (10–14 years) and then reduced gradually, but increased again for older mothers (40+ years). When compared to mothers aged 20–29 years, there was a 23% increased risk of preterm birth, a 60% increased risk of perinatal mortality, a 63% increased risk of neonatal mortality, a 28% increased risk of LBW, and a 22% increased risk of SGA among mothers 10–14 years. Mothers 40+ years experienced a 22% increased risk of preterm birth and a 103% increased risk of stillbirth when compared to the 20–29 year group. Interpretation: The youngest and oldest mothers suffer most from adverse pregnancy and birth outcomes. Policy and programming agendas should consider both biological and socioeconomic/environmental factors when targeting these populations. 2022-03 2024-04-12T13:37:48Z 2024-04-12T13:37:48Z Journal Article https://hdl.handle.net/10568/141379 en Open Access Elsevier Akseer, Nadia; Keats, Emily Catherine; Thurairajah, Pravheen; Cousens, Simon N.; Betran, Ana Pilar; Oaks, Brietta M.; Huybregts, Lieven; et al. 2022. Characteristics and birth outcomes of pregnant adolescents compared to older women: An analysis of individual level data from 140, 000 mothers from 20 RCTs. EClinicalMedicine 45: 101309. https://doi.org/10.1016/j.eclinm.2022.101309 |
| spellingShingle | maternal and child health nutritional status determinants prematurity adolescents pregnant adolescents pregnancy reproductive health pregnancy complications age Akseer, Nadia Keats, Emily Catherine Thurairajah, Pravheen Cousens, Simon N. Betran, Ana Pilar Oaks, Brietta M. Huybregts, Lieven Characteristics and birth outcomes of pregnant adolescents compared to older women: An analysis of individual level data from 140,000 mothers from 20 RCTs |
| title | Characteristics and birth outcomes of pregnant adolescents compared to older women: An analysis of individual level data from 140,000 mothers from 20 RCTs |
| title_full | Characteristics and birth outcomes of pregnant adolescents compared to older women: An analysis of individual level data from 140,000 mothers from 20 RCTs |
| title_fullStr | Characteristics and birth outcomes of pregnant adolescents compared to older women: An analysis of individual level data from 140,000 mothers from 20 RCTs |
| title_full_unstemmed | Characteristics and birth outcomes of pregnant adolescents compared to older women: An analysis of individual level data from 140,000 mothers from 20 RCTs |
| title_short | Characteristics and birth outcomes of pregnant adolescents compared to older women: An analysis of individual level data from 140,000 mothers from 20 RCTs |
| title_sort | characteristics and birth outcomes of pregnant adolescents compared to older women an analysis of individual level data from 140 000 mothers from 20 rcts |
| topic | maternal and child health nutritional status determinants prematurity adolescents pregnant adolescents pregnancy reproductive health pregnancy complications age |
| url | https://hdl.handle.net/10568/141379 |
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