Effects of prenatal nutritional supplements on gestational weight gain in low- and middle-income countries: A meta-analysis of individual participant data
Background: Gestational weight gain (GWG) below or above the Institute of Medicine (IOM) recommendations has been associated with adverse perinatal outcomes. Few studies have examined the effect of prenatal nutrient supplementations on GWG in low- and middle-income countries (LMICs). Objectives: We...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/141373 |
| _version_ | 1855521865311715328 |
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| author | Liu, Enju Wang, Dongqing Darling, Anne M. Perumal, Nandita Wang, Molin Ahmed, Tahmeed Christian, Parul Dewey, Kathryn G. Kac, Gilberto Kennedy, Stephen Subramoney, Vishak Briggs, Brittany Fawzi, Wafaie W. Huybregts, Lieven Members of the GWG Pooling Project Consortium |
| author_browse | Ahmed, Tahmeed Briggs, Brittany Christian, Parul Darling, Anne M. Dewey, Kathryn G. Fawzi, Wafaie W. Huybregts, Lieven Kac, Gilberto Kennedy, Stephen Liu, Enju Members of the GWG Pooling Project Consortium Perumal, Nandita Subramoney, Vishak Wang, Dongqing Wang, Molin |
| author_facet | Liu, Enju Wang, Dongqing Darling, Anne M. Perumal, Nandita Wang, Molin Ahmed, Tahmeed Christian, Parul Dewey, Kathryn G. Kac, Gilberto Kennedy, Stephen Subramoney, Vishak Briggs, Brittany Fawzi, Wafaie W. Huybregts, Lieven Members of the GWG Pooling Project Consortium |
| author_sort | Liu, Enju |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Background: Gestational weight gain (GWG) below or above the Institute of Medicine (IOM) recommendations has been associated with adverse perinatal outcomes. Few studies have examined the effect of prenatal nutrient supplementations on GWG in low- and middle-income countries (LMICs). Objectives: We aimed to investigate the effects of multiple micronutrient supplements (MMSs) and small-quantity lipid-based nutrient supplements (LNSs) on GWG in LMICs. Methods: A 2-stage meta-analysis of individual participant data was conducted to examine the effects of MMSs (45,507 women from 14 trials) and small-quantity LNSs (6237 women from 4 trials) on GWG compared with iron and folic acid supplements only. Percentage adequacy of GWG and total weight gain at delivery were calculated according to the IOM 2009 guidelines. Binary outcomes included severely inadequate (percentage adequacy <70%), inadequate (<90%), and excessive (>125%) GWG. Results from individual trials were pooled using fixed-effects inverse-variance models. Heterogeneity was examined using I2, stratified analysis, and meta-regression. Results: MMSs resulted in a greater percentage adequacy of GWG [weighted mean difference (WMD): 0.86%; 95% CI: 0.28%, 1.44%; P < 0.01] and higher GWG at delivery (WMD: 209 g; 95% CI: 139, 280 g; P < 0.01) than among those in the control arm. Women who received MMSs had a 2.9% reduced risk of severely inadequate GWG (RR: 0.971; 95% CI: 0.956, 0.987; P < 0.01). No association was found between small-quantity LNSs and GWG percentage adequacy (WMD: 1.51%; 95% CI: −0.38%, 3.40%; P = 0.21). Neither MMSs nor small-quantity LNSs were associated with excessive GWG. Conclusions: Maternal MMSs were associated with greater GWG percentage adequacy and total GWG at delivery than was iron and folic acid only. This finding is consistent with previous results on birth outcomes and will inform policy development and local recommendations of switching routine prenatal iron and folic acid supplements to MMSs. |
| format | Journal Article |
| id | CGSpace141373 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace1413732025-10-28T10:12:08Z Effects of prenatal nutritional supplements on gestational weight gain in low- and middle-income countries: A meta-analysis of individual participant data Liu, Enju Wang, Dongqing Darling, Anne M. Perumal, Nandita Wang, Molin Ahmed, Tahmeed Christian, Parul Dewey, Kathryn G. Kac, Gilberto Kennedy, Stephen Subramoney, Vishak Briggs, Brittany Fawzi, Wafaie W. Huybregts, Lieven Members of the GWG Pooling Project Consortium less favoured areas pregnancy weight gain nutrients supplements trace elements developing countries iron folic acid perinatal period Background: Gestational weight gain (GWG) below or above the Institute of Medicine (IOM) recommendations has been associated with adverse perinatal outcomes. Few studies have examined the effect of prenatal nutrient supplementations on GWG in low- and middle-income countries (LMICs). Objectives: We aimed to investigate the effects of multiple micronutrient supplements (MMSs) and small-quantity lipid-based nutrient supplements (LNSs) on GWG in LMICs. Methods: A 2-stage meta-analysis of individual participant data was conducted to examine the effects of MMSs (45,507 women from 14 trials) and small-quantity LNSs (6237 women from 4 trials) on GWG compared with iron and folic acid supplements only. Percentage adequacy of GWG and total weight gain at delivery were calculated according to the IOM 2009 guidelines. Binary outcomes included severely inadequate (percentage adequacy <70%), inadequate (<90%), and excessive (>125%) GWG. Results from individual trials were pooled using fixed-effects inverse-variance models. Heterogeneity was examined using I2, stratified analysis, and meta-regression. Results: MMSs resulted in a greater percentage adequacy of GWG [weighted mean difference (WMD): 0.86%; 95% CI: 0.28%, 1.44%; P < 0.01] and higher GWG at delivery (WMD: 209 g; 95% CI: 139, 280 g; P < 0.01) than among those in the control arm. Women who received MMSs had a 2.9% reduced risk of severely inadequate GWG (RR: 0.971; 95% CI: 0.956, 0.987; P < 0.01). No association was found between small-quantity LNSs and GWG percentage adequacy (WMD: 1.51%; 95% CI: −0.38%, 3.40%; P = 0.21). Neither MMSs nor small-quantity LNSs were associated with excessive GWG. Conclusions: Maternal MMSs were associated with greater GWG percentage adequacy and total GWG at delivery than was iron and folic acid only. This finding is consistent with previous results on birth outcomes and will inform policy development and local recommendations of switching routine prenatal iron and folic acid supplements to MMSs. 2022-12 2024-04-12T13:37:47Z 2024-04-12T13:37:47Z Journal Article https://hdl.handle.net/10568/141373 en Limited Access Elsevier Liu, Enju; Wang, Dongqing; Darling, Anne M.; Perumal, Nandita; Wang, Molin; Ahmed, Tahmeed; et al. 2022. Effects of prenatal nutritional supplements on gestational weight gain in low- and middle-income countries: A meta-analysis of individual participant data. American Journal of Clinical Nutrition 116(6): 1864–1876. https://doi.org/10.1093/ajcn/nqac259 |
| spellingShingle | less favoured areas pregnancy weight gain nutrients supplements trace elements developing countries iron folic acid perinatal period Liu, Enju Wang, Dongqing Darling, Anne M. Perumal, Nandita Wang, Molin Ahmed, Tahmeed Christian, Parul Dewey, Kathryn G. Kac, Gilberto Kennedy, Stephen Subramoney, Vishak Briggs, Brittany Fawzi, Wafaie W. Huybregts, Lieven Members of the GWG Pooling Project Consortium Effects of prenatal nutritional supplements on gestational weight gain in low- and middle-income countries: A meta-analysis of individual participant data |
| title | Effects of prenatal nutritional supplements on gestational weight gain in low- and middle-income countries: A meta-analysis of individual participant data |
| title_full | Effects of prenatal nutritional supplements on gestational weight gain in low- and middle-income countries: A meta-analysis of individual participant data |
| title_fullStr | Effects of prenatal nutritional supplements on gestational weight gain in low- and middle-income countries: A meta-analysis of individual participant data |
| title_full_unstemmed | Effects of prenatal nutritional supplements on gestational weight gain in low- and middle-income countries: A meta-analysis of individual participant data |
| title_short | Effects of prenatal nutritional supplements on gestational weight gain in low- and middle-income countries: A meta-analysis of individual participant data |
| title_sort | effects of prenatal nutritional supplements on gestational weight gain in low and middle income countries a meta analysis of individual participant data |
| topic | less favoured areas pregnancy weight gain nutrients supplements trace elements developing countries iron folic acid perinatal period |
| url | https://hdl.handle.net/10568/141373 |
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