Modeling relationships between iron status, behavior, and brain electrophysiology: Evidence from a randomized study involving a biofortified grain in Indian adolescents
Background: Iron deficiency (ID) and iron deficiency anemia (IDA) are highly-prevalent nutrient deficiencies and have been shown to have a range of negative effects on cognition and brain function. Human intervention studies including measures at three levels—blood, brain, and behavior—are rare and...
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| Format: | Journal Article |
| Language: | Inglés |
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Springer
2022
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| Online Access: | https://hdl.handle.net/10568/141262 |
| _version_ | 1855520952138334208 |
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| author | Wenger, Michael J. Murray-Kolb, Laura E. Scott, Samuel P. Boy, Erick Haas, Jere D. |
| author_browse | Boy, Erick Haas, Jere D. Murray-Kolb, Laura E. Scott, Samuel P. Wenger, Michael J. |
| author_facet | Wenger, Michael J. Murray-Kolb, Laura E. Scott, Samuel P. Boy, Erick Haas, Jere D. |
| author_sort | Wenger, Michael J. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Background: Iron deficiency (ID) and iron deficiency anemia (IDA) are highly-prevalent nutrient deficiencies and have been shown to have a range of negative effects on cognition and brain function. Human intervention studies including measures at three levels—blood, brain, and behavior—are rare and our objective was to model the relationships among measures at these three levels in school-going Indian adolescents. Methods: Male and female adolescents in rural India were screened for ID/IDA. Subjects consumed 2 meals/day for 6 months; half were randomly assigned to consume meals made from a standard grain (pearl millet) and half consumed meals made from an iron biofortified pearl millet (BPM). Prior to and then at the conclusion of the feeding trial, they completed a set of cognitive tests with concurrent electroencephalography (EEG). Results: Overall, serum ferritin (sFt) levels improved over the course of the study. Ten of 21 possible measures of cognition showed improvements from baseline (BL) to endline (EL) that were larger for those consuming BPM than for those consuming the comparison pearl millet (CPM). Critically, the best model for the relationship between change in iron status and change in cognition had change in brain measures as a mediating factor, with both change in serum ferritin as a primary predictor and change in hemoglobin as a moderator. Conclusions: A dietary intervention involving a biofortified staple grain was shown to be efficacious in improving blood iron biomarkers, behavioral measures of cognition, and EEG measures of brain function. Modeling the relationships among these variables strongly suggests multiple mechanisms by which blood iron level affects brain function and cognition. |
| format | Journal Article |
| id | CGSpace141262 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace1412622025-10-26T13:02:06Z Modeling relationships between iron status, behavior, and brain electrophysiology: Evidence from a randomized study involving a biofortified grain in Indian adolescents Wenger, Michael J. Murray-Kolb, Laura E. Scott, Samuel P. Boy, Erick Haas, Jere D. electroencephalography anaemia memory pearl millet cognition adolescents biofortification trace element deficiencies nutrient deficiencies brain blood iron behaviour Background: Iron deficiency (ID) and iron deficiency anemia (IDA) are highly-prevalent nutrient deficiencies and have been shown to have a range of negative effects on cognition and brain function. Human intervention studies including measures at three levels—blood, brain, and behavior—are rare and our objective was to model the relationships among measures at these three levels in school-going Indian adolescents. Methods: Male and female adolescents in rural India were screened for ID/IDA. Subjects consumed 2 meals/day for 6 months; half were randomly assigned to consume meals made from a standard grain (pearl millet) and half consumed meals made from an iron biofortified pearl millet (BPM). Prior to and then at the conclusion of the feeding trial, they completed a set of cognitive tests with concurrent electroencephalography (EEG). Results: Overall, serum ferritin (sFt) levels improved over the course of the study. Ten of 21 possible measures of cognition showed improvements from baseline (BL) to endline (EL) that were larger for those consuming BPM than for those consuming the comparison pearl millet (CPM). Critically, the best model for the relationship between change in iron status and change in cognition had change in brain measures as a mediating factor, with both change in serum ferritin as a primary predictor and change in hemoglobin as a moderator. Conclusions: A dietary intervention involving a biofortified staple grain was shown to be efficacious in improving blood iron biomarkers, behavioral measures of cognition, and EEG measures of brain function. Modeling the relationships among these variables strongly suggests multiple mechanisms by which blood iron level affects brain function and cognition. 2022-07-06 2024-04-12T13:37:34Z 2024-04-12T13:37:34Z Journal Article https://hdl.handle.net/10568/141262 en https://doi.org/10.3945/jn.117.255356 http://doi.org/10.1186/s12889-022-13897-0 Open Access Springer Wenger, Michael J.; Murray-Kolb, Laura E.; Scott, Samuel; Boy, Erick; and Haas, Jere D. 2022. Modeling relationships between iron status, behavior, and brain electrophysiology: Evidence from a randomized study involving a biofortified grain in Indian adolescents. BMC Public Health 22: 1299. https://doi.org/10.1186/s12889-022-13612-z |
| spellingShingle | electroencephalography anaemia memory pearl millet cognition adolescents biofortification trace element deficiencies nutrient deficiencies brain blood iron behaviour Wenger, Michael J. Murray-Kolb, Laura E. Scott, Samuel P. Boy, Erick Haas, Jere D. Modeling relationships between iron status, behavior, and brain electrophysiology: Evidence from a randomized study involving a biofortified grain in Indian adolescents |
| title | Modeling relationships between iron status, behavior, and brain electrophysiology: Evidence from a randomized study involving a biofortified grain in Indian adolescents |
| title_full | Modeling relationships between iron status, behavior, and brain electrophysiology: Evidence from a randomized study involving a biofortified grain in Indian adolescents |
| title_fullStr | Modeling relationships between iron status, behavior, and brain electrophysiology: Evidence from a randomized study involving a biofortified grain in Indian adolescents |
| title_full_unstemmed | Modeling relationships between iron status, behavior, and brain electrophysiology: Evidence from a randomized study involving a biofortified grain in Indian adolescents |
| title_short | Modeling relationships between iron status, behavior, and brain electrophysiology: Evidence from a randomized study involving a biofortified grain in Indian adolescents |
| title_sort | modeling relationships between iron status behavior and brain electrophysiology evidence from a randomized study involving a biofortified grain in indian adolescents |
| topic | electroencephalography anaemia memory pearl millet cognition adolescents biofortification trace element deficiencies nutrient deficiencies brain blood iron behaviour |
| url | https://hdl.handle.net/10568/141262 |
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