Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes
East Coast fever, caused by the tick-borne intracellular apicomplexan parasite Theileria parva, is a highly fatal lymphoproliferative disease of cattle. The pathogenic schizont-induced lymphocyte transformation is a unique cancer-like condition that is reversible with parasite removal. Schizont-infe...
| Autores principales: | , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
National Academy of Sciences
2006
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/1406 |
| _version_ | 1855532138571497472 |
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| author | Graham, S.P. Pelle, Roger Honda, Y. Mwangi, David Miano Tonukari, N.J. Yamage, M. Glew, E.J. Villiers, Etienne P. de |
| author_browse | Glew, E.J. Graham, S.P. Honda, Y. Mwangi, David Miano Pelle, Roger Tonukari, N.J. Villiers, Etienne P. de Yamage, M. |
| author_facet | Graham, S.P. Pelle, Roger Honda, Y. Mwangi, David Miano Tonukari, N.J. Yamage, M. Glew, E.J. Villiers, Etienne P. de |
| author_sort | Graham, S.P. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | East Coast fever, caused by the tick-borne intracellular apicomplexan parasite Theileria parva, is a highly fatal lymphoproliferative disease of cattle. The pathogenic schizont-induced lymphocyte transformation is a unique cancer-like condition that is reversible with parasite removal. Schizont-infected cell-directed CD8+ cytotoxic T lymphocytes (CTL) constitute the dominant protective bovine immune response after a single exposure to infection. However, the schizont antigens targeted by T. parva-specific CTL are undefined. Here we show the identification of five candidate vaccine antigens that are the targets of MHC class I-restricted CD8+ CTL from immune cattle. CD8+ T cell responses to these antigens were boosted in T. parva-immune cattle resolving a challenge infection and, when used to immunize naïve cattle, induced CTL responses that significantly correlated with survival from a lethal parasite challenge. These data provide a basis for developing a CTL-targeted anti-East Coast fever subunit vaccine. In addition, orthologs of these antigens may be vaccine targets for other apicomplexan parasites. |
| format | Journal Article |
| id | CGSpace1406 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2006 |
| publishDateRange | 2006 |
| publishDateSort | 2006 |
| publisher | National Academy of Sciences |
| publisherStr | National Academy of Sciences |
| record_format | dspace |
| spelling | CGSpace14062024-10-17T09:47:53Z Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes Graham, S.P. Pelle, Roger Honda, Y. Mwangi, David Miano Tonukari, N.J. Yamage, M. Glew, E.J. Villiers, Etienne P. de animal diseases disease control East Coast fever, caused by the tick-borne intracellular apicomplexan parasite Theileria parva, is a highly fatal lymphoproliferative disease of cattle. The pathogenic schizont-induced lymphocyte transformation is a unique cancer-like condition that is reversible with parasite removal. Schizont-infected cell-directed CD8+ cytotoxic T lymphocytes (CTL) constitute the dominant protective bovine immune response after a single exposure to infection. However, the schizont antigens targeted by T. parva-specific CTL are undefined. Here we show the identification of five candidate vaccine antigens that are the targets of MHC class I-restricted CD8+ CTL from immune cattle. CD8+ T cell responses to these antigens were boosted in T. parva-immune cattle resolving a challenge infection and, when used to immunize naïve cattle, induced CTL responses that significantly correlated with survival from a lethal parasite challenge. These data provide a basis for developing a CTL-targeted anti-East Coast fever subunit vaccine. In addition, orthologs of these antigens may be vaccine targets for other apicomplexan parasites. 2006-02-28 2010-05-07T11:05:01Z 2010-05-07T11:05:01Z Journal Article https://hdl.handle.net/10568/1406 en Open Access National Academy of Sciences Graham S., et al. 2006. Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes. Proceedings of the National Academy of Sciences of the United States of America (PNAS) 103(9):3286-3291. |
| spellingShingle | animal diseases disease control Graham, S.P. Pelle, Roger Honda, Y. Mwangi, David Miano Tonukari, N.J. Yamage, M. Glew, E.J. Villiers, Etienne P. de Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes |
| title | Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes |
| title_full | Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes |
| title_fullStr | Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes |
| title_full_unstemmed | Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes |
| title_short | Theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic T lymphocytes |
| title_sort | theileria parva candidate vaccine antigens recognized by immune bovine cytotoxic t lymphocytes |
| topic | animal diseases disease control |
| url | https://hdl.handle.net/10568/1406 |
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