Lactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model
Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted a relationship between the gut microbiota and gout, whether the microbiota could ameliorate HUA-associated systemic purine metabolism remains unclear. In this study, we constructed a...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Springer
2024
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/140536 |
| _version_ | 1855528429845217280 |
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| author | Yang Fu Yong-Song Chen Dai-Yang Xia Xiao-Dan Luo Hao-Tong Luo Jie Pan Wei-Qing Ma Jin-Ze Li Qian-Yuan Mo Qiang Tu Meng-Meng Li Yue Zhao Yu Li Yi-Teng Huang Zhi-Xian Chen Zhen-Jun Li Lukuyu, Ben A. Dione, Michel M. You-Ming Zhang Kai Miao Jian-Ying Chen Shan-Shan Zhu Jie Ren Ling-Juan Zhou Xian-Zhi Jiang Juan Chen Zhen-Ping Lin Jun-Peng Chen Hui Ye Qing-Yun Cao Yong-Wen Zhu Lin Yang Xue Wang Wen-Ce Wang |
| author_browse | Dai-Yang Xia Dione, Michel M. Hao-Tong Luo Hui Ye Jian-Ying Chen Jie Pan Jie Ren Jin-Ze Li Juan Chen Jun-Peng Chen Kai Miao Lin Yang Ling-Juan Zhou Lukuyu, Ben A. Meng-Meng Li Qian-Yuan Mo Qiang Tu Qing-Yun Cao Shan-Shan Zhu Wei-Qing Ma Wen-Ce Wang Xian-Zhi Jiang Xiao-Dan Luo Xue Wang Yang Fu Yi-Teng Huang Yong-Song Chen Yong-Wen Zhu You-Ming Zhang Yu Li Yue Zhao Zhen-Jun Li Zhen-Ping Lin Zhi-Xian Chen |
| author_facet | Yang Fu Yong-Song Chen Dai-Yang Xia Xiao-Dan Luo Hao-Tong Luo Jie Pan Wei-Qing Ma Jin-Ze Li Qian-Yuan Mo Qiang Tu Meng-Meng Li Yue Zhao Yu Li Yi-Teng Huang Zhi-Xian Chen Zhen-Jun Li Lukuyu, Ben A. Dione, Michel M. You-Ming Zhang Kai Miao Jian-Ying Chen Shan-Shan Zhu Jie Ren Ling-Juan Zhou Xian-Zhi Jiang Juan Chen Zhen-Ping Lin Jun-Peng Chen Hui Ye Qing-Yun Cao Yong-Wen Zhu Lin Yang Xue Wang Wen-Ce Wang |
| author_sort | Yang Fu |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted a relationship between the gut microbiota and gout, whether the microbiota could ameliorate HUA-associated systemic purine metabolism remains unclear. In this study, we constructed a novel model of HUA in geese and investigated the mechanism by which <i>Lactobacillus rhamnosus</i> GG (LGG) could have beneficial effects on HUA. The administration of antibiotics and fecal microbiota transplantation (FMT) experiments were used in this HUA goose model. The effects of LGG and its metabolites on HUA were evaluated in vivo and in vitro. Heterogeneous expression and gene knockout of LGG revealed the mechanism of LGG. Multi-omics analysis revealed that the <i>Lactobacillus</i> genus is associated with changes in purine metabolism in HUA. This study showed that LGG and its metabolites could alleviate HUA through the gut-liver-kidney axis. Whole-genome analysis, heterogeneous expression, and gene knockout of LGG enzymes ABC-type multidrug transport system (<i>ABCT</i>), inosine-uridine nucleoside N-ribohydrolase (<i>iunH</i>), and xanthine permease (<i>pbuX</i>) demonstrated the function of nucleoside degradation in LGG. Multi-omics and a correlation analysis in HUA patients and this goose model revealed that a serum proline deficiency, as well as changes in <i>Collinsella</i> and <i>Lactobacillus</i>, may be associated with the occurrence of HUA. Our findings demonstrated the potential of a goose model of diet-induced HUA, and LGG and proline could be promising therapies for HUA. |
| format | Journal Article |
| id | CGSpace140536 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace1405362025-12-08T10:11:39Z Lactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model Yang Fu Yong-Song Chen Dai-Yang Xia Xiao-Dan Luo Hao-Tong Luo Jie Pan Wei-Qing Ma Jin-Ze Li Qian-Yuan Mo Qiang Tu Meng-Meng Li Yue Zhao Yu Li Yi-Teng Huang Zhi-Xian Chen Zhen-Jun Li Lukuyu, Ben A. Dione, Michel M. You-Ming Zhang Kai Miao Jian-Ying Chen Shan-Shan Zhu Jie Ren Ling-Juan Zhou Xian-Zhi Jiang Juan Chen Zhen-Ping Lin Jun-Peng Chen Hui Ye Qing-Yun Cao Yong-Wen Zhu Lin Yang Xue Wang Wen-Ce Wang health Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted a relationship between the gut microbiota and gout, whether the microbiota could ameliorate HUA-associated systemic purine metabolism remains unclear. In this study, we constructed a novel model of HUA in geese and investigated the mechanism by which <i>Lactobacillus rhamnosus</i> GG (LGG) could have beneficial effects on HUA. The administration of antibiotics and fecal microbiota transplantation (FMT) experiments were used in this HUA goose model. The effects of LGG and its metabolites on HUA were evaluated in vivo and in vitro. Heterogeneous expression and gene knockout of LGG revealed the mechanism of LGG. Multi-omics analysis revealed that the <i>Lactobacillus</i> genus is associated with changes in purine metabolism in HUA. This study showed that LGG and its metabolites could alleviate HUA through the gut-liver-kidney axis. Whole-genome analysis, heterogeneous expression, and gene knockout of LGG enzymes ABC-type multidrug transport system (<i>ABCT</i>), inosine-uridine nucleoside N-ribohydrolase (<i>iunH</i>), and xanthine permease (<i>pbuX</i>) demonstrated the function of nucleoside degradation in LGG. Multi-omics and a correlation analysis in HUA patients and this goose model revealed that a serum proline deficiency, as well as changes in <i>Collinsella</i> and <i>Lactobacillus</i>, may be associated with the occurrence of HUA. Our findings demonstrated the potential of a goose model of diet-induced HUA, and LGG and proline could be promising therapies for HUA. 2024-03-20 2024-03-21T08:56:33Z 2024-03-21T08:56:33Z Journal Article https://hdl.handle.net/10568/140536 en Open Access Springer Yang Fu, Yong-Song Chen, Dai-Yang Xia, Xiao-Dan Luo, Hao-Tong Luo, Jie Pan, Wei-Qing Ma, Jin-Ze Li, Qian-Yuan Mo, Qiang Tu, Meng-Meng Li, Yue Zhao, Yu Li, Yi-Teng Huang, Zhi-Xian Chen, Zhen-Jun Li, Lukuyu, B., Dione, M., You-Ming Zhang, Kai Miao, Jian-Ying Chen, Shan-Shan Zhu, Jie Ren, Ling-Juan Zhou, Xian-Zhi Jiang, Juan Chen, Zhen-Ping Lin, Jun-Peng Chen, Hui Ye, Qing-Yun Cao, Yong-Wen Zhu, Lin Yang, Xue Wang and Wen-Ce Wang. 2024. <i>Lactobacillus rhamnosus</i> GG ameliorates hyperuricemia in a novel model. <i>npj Biofilms Microbiomes</i> 10: 25. |
| spellingShingle | health Yang Fu Yong-Song Chen Dai-Yang Xia Xiao-Dan Luo Hao-Tong Luo Jie Pan Wei-Qing Ma Jin-Ze Li Qian-Yuan Mo Qiang Tu Meng-Meng Li Yue Zhao Yu Li Yi-Teng Huang Zhi-Xian Chen Zhen-Jun Li Lukuyu, Ben A. Dione, Michel M. You-Ming Zhang Kai Miao Jian-Ying Chen Shan-Shan Zhu Jie Ren Ling-Juan Zhou Xian-Zhi Jiang Juan Chen Zhen-Ping Lin Jun-Peng Chen Hui Ye Qing-Yun Cao Yong-Wen Zhu Lin Yang Xue Wang Wen-Ce Wang Lactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model |
| title | Lactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model |
| title_full | Lactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model |
| title_fullStr | Lactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model |
| title_full_unstemmed | Lactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model |
| title_short | Lactobacillus rhamnosus GG ameliorates hyperuricemia in a novel model |
| title_sort | lactobacillus rhamnosus gg ameliorates hyperuricemia in a novel model |
| topic | health |
| url | https://hdl.handle.net/10568/140536 |
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