Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ
Tumor necrosis factor alpha (Tnf) plays a pleiotropic role in murine malaria. Some investigations have correlated Tnf with hypothermia, hyperlactatemia, hypoglycemia, and a suppression of the erythropoietic response, although others have not. In this study, we have evaluated parasitemia, survival ra...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Elsevier
2006
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/1400 |
| _version_ | 1855522400158875648 |
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| author | Hernández Valladares, M. Naessens, Jan Musoke, A.J. Sekikawa, K. Rihet, P. Ole-MoiYoi, O.K. Busher, P. Iraqi, F.A. |
| author_browse | Busher, P. Hernández Valladares, M. Iraqi, F.A. Musoke, A.J. Naessens, Jan Ole-MoiYoi, O.K. Rihet, P. Sekikawa, K. |
| author_facet | Hernández Valladares, M. Naessens, Jan Musoke, A.J. Sekikawa, K. Rihet, P. Ole-MoiYoi, O.K. Busher, P. Iraqi, F.A. |
| author_sort | Hernández Valladares, M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Tumor necrosis factor alpha (Tnf) plays a pleiotropic role in murine malaria. Some investigations have correlated Tnf with hypothermia, hyperlactatemia, hypoglycemia, and a suppression of the erythropoietic response, although others have not. In this study, we have evaluated parasitemia, survival rate and several pathological features in C57BL/6JTnf−/− and C57BL/6JTnf+/+ mice after infection with Plasmodium chabaudi adami 408XZ. Compared to the C57BL/6JTnf+/+ mice, C57BL/6JTnf−/− mice showed increased parasitemia and decreased survival rate, whereas blood glucose, blood lactate and body weight were not significantly different. However, C57BL/6JTnf−/− mice suffered significantly more from severe anemia and hypothermia than C57BL/6JTnf+/+ mice. These results suggest that Tnf is an important mediator of parasite control, but not of anemia development. We hypothesize that the high mortality observed in the Tnf knock-out mice is due to increased anemia and pathology as a direct result of increased levels of parasitemia. |
| format | Journal Article |
| id | CGSpace1400 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2006 |
| publishDateRange | 2006 |
| publishDateSort | 2006 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace14002023-12-08T19:36:04Z Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ Hernández Valladares, M. Naessens, Jan Musoke, A.J. Sekikawa, K. Rihet, P. Ole-MoiYoi, O.K. Busher, P. Iraqi, F.A. disease control animal diseases Tumor necrosis factor alpha (Tnf) plays a pleiotropic role in murine malaria. Some investigations have correlated Tnf with hypothermia, hyperlactatemia, hypoglycemia, and a suppression of the erythropoietic response, although others have not. In this study, we have evaluated parasitemia, survival rate and several pathological features in C57BL/6JTnf−/− and C57BL/6JTnf+/+ mice after infection with Plasmodium chabaudi adami 408XZ. Compared to the C57BL/6JTnf+/+ mice, C57BL/6JTnf−/− mice showed increased parasitemia and decreased survival rate, whereas blood glucose, blood lactate and body weight were not significantly different. However, C57BL/6JTnf−/− mice suffered significantly more from severe anemia and hypothermia than C57BL/6JTnf+/+ mice. These results suggest that Tnf is an important mediator of parasite control, but not of anemia development. We hypothesize that the high mortality observed in the Tnf knock-out mice is due to increased anemia and pathology as a direct result of increased levels of parasitemia. 2006-12 2010-05-07T10:57:07Z 2010-05-07T10:57:07Z Journal Article https://hdl.handle.net/10568/1400 en Limited Access Elsevier Hernandez-Valladares, M.; Naessens, J.; Musoke, A.J.; Sekikawa, K.; Rihet, P.; ole-MoiYoi, O.K.; Büscher, P.; Iraqi, F. 2006. Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ. Experimental Parasitology 114(4):271-278. |
| spellingShingle | disease control animal diseases Hernández Valladares, M. Naessens, Jan Musoke, A.J. Sekikawa, K. Rihet, P. Ole-MoiYoi, O.K. Busher, P. Iraqi, F.A. Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ |
| title | Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ |
| title_full | Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ |
| title_fullStr | Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ |
| title_full_unstemmed | Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ |
| title_short | Pathology of Tnf-deficient mice infected with Plasmodium chabaudi adami 408XZ |
| title_sort | pathology of tnf deficient mice infected with plasmodium chabaudi adami 408xz |
| topic | disease control animal diseases |
| url | https://hdl.handle.net/10568/1400 |
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