Long term association between of maternal preconception hemoglobin and anemia and child health and development in Vietnam
Background: The long-term association between preconception maternal hemoglobin (Hb) concentrations and child health and development is unclear. Objective: We examined associations between maternal preconception Hb concentrations and anemia with: a) birth outcomes (weight, length, preterm, gestation...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2023
|
| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/139977 |
| _version_ | 1855526835755941888 |
|---|---|
| author | Young, Melissa F. Nguyen, Phuong Hong Tran, Lan Mai Khuong, Long Quynh Martorell, Reynaldo Ramakrishnan, Usha |
| author_browse | Khuong, Long Quynh Martorell, Reynaldo Nguyen, Phuong Hong Ramakrishnan, Usha Tran, Lan Mai Young, Melissa F. |
| author_facet | Young, Melissa F. Nguyen, Phuong Hong Tran, Lan Mai Khuong, Long Quynh Martorell, Reynaldo Ramakrishnan, Usha |
| author_sort | Young, Melissa F. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Background: The long-term association between preconception maternal hemoglobin (Hb) concentrations and child health and development is unclear. Objective: We examined associations between maternal preconception Hb concentrations and anemia with: a) birth outcomes (weight, length, preterm, gestational age, small-for-gestational-age); b) child Hb at 3 mo, 6 mo, 12 mo, and 24 mo; c) motor and mental development at 12 mo and 24 mo (Bayley scales for infant development) and cognitive functioning at 6-7y (Wechsler Intelligence Scale for Children). Methods: We used data from a randomized controlled trial (PRECONCEPT) conducted in Vietnam. Over 5000 women who were intending to conceive were recruited and offspring were prospectively followed from birth (n=1599) through 6-7y (n=1318). Multivariable linear and logistic regressions were used to assess the association between preconception Hb or anemia (Hb < 11g/dL) on child health and development outcomes, adjusted by supplementation group (tested for interactions) and confounding at maternal, child and household levels. Results: At preconception enrollment, 20% of the women were anemic. Maternal preconception Hb was positively associated with child Hb at 3 mo (0.06; 95% CI: 0.01,0.12), 6 mo (0.08; 95% CI: 0.03,0.13), 12 mo (0.10; 95% CI: 0.04-0.15) and 24 mo (0.07; 95% CI: 0.02,0.12). Likewise, maternal preconception Hb was associated with reduced risk of child anemia at 6mo (0.89; 95% CI: 0.81-0.98), 12 mo (0.81; 95% CI: 0.74-0.89) and 24 mo (0.87; 95% CI: 0.79-0.95). Maternal preconception anemia was negatively associated with cognition (-1.64; 95% CI: -3.09, -0.19) and language development (-1.61; 95% CI: -3.20, -0.03) at 24mo. Preconception Hb was not associated with birth outcomes or cognitive outcomes at 6-7y. Conclusion: Maternal preconception Hb was associated with child Hb across the first 1000 days of life. However, preconception Hb was not a significant predictor of birth outcomes or cognitive outcomes at 6-7y in this cohort from Vietnam. |
| format | Journal Article |
| id | CGSpace139977 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace1399772025-12-08T10:11:39Z Long term association between of maternal preconception hemoglobin and anemia and child health and development in Vietnam Young, Melissa F. Nguyen, Phuong Hong Tran, Lan Mai Khuong, Long Quynh Martorell, Reynaldo Ramakrishnan, Usha maternal and child health anaemia child health infant development haemoglobin women data analysis data child development maternal nutrition Background: The long-term association between preconception maternal hemoglobin (Hb) concentrations and child health and development is unclear. Objective: We examined associations between maternal preconception Hb concentrations and anemia with: a) birth outcomes (weight, length, preterm, gestational age, small-for-gestational-age); b) child Hb at 3 mo, 6 mo, 12 mo, and 24 mo; c) motor and mental development at 12 mo and 24 mo (Bayley scales for infant development) and cognitive functioning at 6-7y (Wechsler Intelligence Scale for Children). Methods: We used data from a randomized controlled trial (PRECONCEPT) conducted in Vietnam. Over 5000 women who were intending to conceive were recruited and offspring were prospectively followed from birth (n=1599) through 6-7y (n=1318). Multivariable linear and logistic regressions were used to assess the association between preconception Hb or anemia (Hb < 11g/dL) on child health and development outcomes, adjusted by supplementation group (tested for interactions) and confounding at maternal, child and household levels. Results: At preconception enrollment, 20% of the women were anemic. Maternal preconception Hb was positively associated with child Hb at 3 mo (0.06; 95% CI: 0.01,0.12), 6 mo (0.08; 95% CI: 0.03,0.13), 12 mo (0.10; 95% CI: 0.04-0.15) and 24 mo (0.07; 95% CI: 0.02,0.12). Likewise, maternal preconception Hb was associated with reduced risk of child anemia at 6mo (0.89; 95% CI: 0.81-0.98), 12 mo (0.81; 95% CI: 0.74-0.89) and 24 mo (0.87; 95% CI: 0.79-0.95). Maternal preconception anemia was negatively associated with cognition (-1.64; 95% CI: -3.09, -0.19) and language development (-1.61; 95% CI: -3.20, -0.03) at 24mo. Preconception Hb was not associated with birth outcomes or cognitive outcomes at 6-7y. Conclusion: Maternal preconception Hb was associated with child Hb across the first 1000 days of life. However, preconception Hb was not a significant predictor of birth outcomes or cognitive outcomes at 6-7y in this cohort from Vietnam. 2023-05 2024-03-14T12:08:47Z 2024-03-14T12:08:47Z Journal Article https://hdl.handle.net/10568/139977 en Open Access Elsevier Young, M. F., Nguyen, P., Tran, L. M., Khuong, L. Q., Martorell, R., & Ramakrishnan, U. (2023). Long-Term Association Between Maternal Preconception Hemoglobin Concentration, Anemia, and Child Health and Development in Vietnam. In The Journal of Nutrition (Vol. 153, Issue 5, pp. 1597–1606). Elsevier BV. https://doi.org/10.1016/j.tjnut.2023.03.015 |
| spellingShingle | maternal and child health anaemia child health infant development haemoglobin women data analysis data child development maternal nutrition Young, Melissa F. Nguyen, Phuong Hong Tran, Lan Mai Khuong, Long Quynh Martorell, Reynaldo Ramakrishnan, Usha Long term association between of maternal preconception hemoglobin and anemia and child health and development in Vietnam |
| title | Long term association between of maternal preconception hemoglobin and anemia and child health and development in Vietnam |
| title_full | Long term association between of maternal preconception hemoglobin and anemia and child health and development in Vietnam |
| title_fullStr | Long term association between of maternal preconception hemoglobin and anemia and child health and development in Vietnam |
| title_full_unstemmed | Long term association between of maternal preconception hemoglobin and anemia and child health and development in Vietnam |
| title_short | Long term association between of maternal preconception hemoglobin and anemia and child health and development in Vietnam |
| title_sort | long term association between of maternal preconception hemoglobin and anemia and child health and development in vietnam |
| topic | maternal and child health anaemia child health infant development haemoglobin women data analysis data child development maternal nutrition |
| url | https://hdl.handle.net/10568/139977 |
| work_keys_str_mv | AT youngmelissaf longtermassociationbetweenofmaternalpreconceptionhemoglobinandanemiaandchildhealthanddevelopmentinvietnam AT nguyenphuonghong longtermassociationbetweenofmaternalpreconceptionhemoglobinandanemiaandchildhealthanddevelopmentinvietnam AT tranlanmai longtermassociationbetweenofmaternalpreconceptionhemoglobinandanemiaandchildhealthanddevelopmentinvietnam AT khuonglongquynh longtermassociationbetweenofmaternalpreconceptionhemoglobinandanemiaandchildhealthanddevelopmentinvietnam AT martorellreynaldo longtermassociationbetweenofmaternalpreconceptionhemoglobinandanemiaandchildhealthanddevelopmentinvietnam AT ramakrishnanusha longtermassociationbetweenofmaternalpreconceptionhemoglobinandanemiaandchildhealthanddevelopmentinvietnam |