Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response
C57BL/6 mice deficient in one or two copies of the gene for tumor necrosis factor alpha (TNF-α) were more susceptible to Trypanosoma congolense infection than their resistant, wild-type counterparts. The number of TNF-α genes was correlated with the capacity to control parasitaemia and with survival...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2004
|
| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/1397 |
| _version_ | 1855535306801938432 |
|---|---|
| author | Naessens, Jan Kitani, H. Momotani, E. Sekikawa, K. Nthale, J.M. Iraqi, F.A. |
| author_browse | Iraqi, F.A. Kitani, H. Momotani, E. Naessens, Jan Nthale, J.M. Sekikawa, K. |
| author_facet | Naessens, Jan Kitani, H. Momotani, E. Sekikawa, K. Nthale, J.M. Iraqi, F.A. |
| author_sort | Naessens, Jan |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | C57BL/6 mice deficient in one or two copies of the gene for tumor necrosis factor alpha (TNF-α) were more susceptible to Trypanosoma congolense infection than their resistant, wild-type counterparts. The number of TNF-α genes was correlated with the capacity to control parasitaemia and with survival time. Absence of TNF-α resulted in a diminished capacity to form germinal centres in lymph nodes and spleen. Since germinal centres are involved in antibody production and affinity maturation, the susceptibility of the TNF-α-deficient mice could have been due to this secondary defect. Despite the lack of the germinal centres, the antibody responses to internal and exposed trypanosome antigens and to non-trypanosome antigens were not significantly different. Also the relative avidities measured in infected sera did not significantly differ between the two mouse strains. These data suggest that the role of TNF-α in control of T. congolense was not due to its role in the development of an antibody response. |
| format | Journal Article |
| id | CGSpace1397 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2004 |
| publishDateRange | 2004 |
| publishDateSort | 2004 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace13972024-03-25T06:37:54Z Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response Naessens, Jan Kitani, H. Momotani, E. Sekikawa, K. Nthale, J.M. Iraqi, F.A. trypanosomosis disease control trypanosoma congolense disease resistance antibodies cytokines infectious diseases parasitology C57BL/6 mice deficient in one or two copies of the gene for tumor necrosis factor alpha (TNF-α) were more susceptible to Trypanosoma congolense infection than their resistant, wild-type counterparts. The number of TNF-α genes was correlated with the capacity to control parasitaemia and with survival time. Absence of TNF-α resulted in a diminished capacity to form germinal centres in lymph nodes and spleen. Since germinal centres are involved in antibody production and affinity maturation, the susceptibility of the TNF-α-deficient mice could have been due to this secondary defect. Despite the lack of the germinal centres, the antibody responses to internal and exposed trypanosome antigens and to non-trypanosome antigens were not significantly different. Also the relative avidities measured in infected sera did not significantly differ between the two mouse strains. These data suggest that the role of TNF-α in control of T. congolense was not due to its role in the development of an antibody response. 2004-11 2010-05-06T09:17:15Z 2010-05-06T09:17:15Z Journal Article https://hdl.handle.net/10568/1397 en Limited Access Elsevier Naessens, J.; Kitani, H.; Momotani, E.; Sekikawa, K.; Nthale, J.M.; Iraqi, F. 2004. Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response. Acta Tropica 92(3):193-204. |
| spellingShingle | trypanosomosis disease control trypanosoma congolense disease resistance antibodies cytokines infectious diseases parasitology Naessens, Jan Kitani, H. Momotani, E. Sekikawa, K. Nthale, J.M. Iraqi, F.A. Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response |
| title | Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response |
| title_full | Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response |
| title_fullStr | Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response |
| title_full_unstemmed | Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response |
| title_short | Susceptibility of TNF-α-deficient mice to Trypanosoma congolense is not due to a defective antibody response |
| title_sort | susceptibility of tnf α deficient mice to trypanosoma congolense is not due to a defective antibody response |
| topic | trypanosomosis disease control trypanosoma congolense disease resistance antibodies cytokines infectious diseases parasitology |
| url | https://hdl.handle.net/10568/1397 |
| work_keys_str_mv | AT naessensjan susceptibilityoftnfadeficientmicetotrypanosomacongolenseisnotduetoadefectiveantibodyresponse AT kitanih susceptibilityoftnfadeficientmicetotrypanosomacongolenseisnotduetoadefectiveantibodyresponse AT momotanie susceptibilityoftnfadeficientmicetotrypanosomacongolenseisnotduetoadefectiveantibodyresponse AT sekikawak susceptibilityoftnfadeficientmicetotrypanosomacongolenseisnotduetoadefectiveantibodyresponse AT nthalejm susceptibilityoftnfadeficientmicetotrypanosomacongolenseisnotduetoadefectiveantibodyresponse AT iraqifa susceptibilityoftnfadeficientmicetotrypanosomacongolenseisnotduetoadefectiveantibodyresponse |