Causes and consequences of child growth faltering in low-resource settings
Growth faltering in children (low length for age or low weight for length) during the first 1,000 days of life (from conception to 2 years of age) influences short-term and long-term health and survival1,2. Interventions such as nutritional supplementation during pregnancy and the postnatal period c...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Springer
2023
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| Online Access: | https://hdl.handle.net/10568/139385 |
| _version_ | 1855520284862316544 |
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| author | Mertens, Andrew Benjamin-Chung, Jade Colford Jr, John M Coyle, Jeremy van der Laan, Mark Hubbard, J. Alan E Rosete, Sonali Malenica, Ivana Hejazi, Nima Sofrygin, Oleg Cai, Wilson Li, Haodong Nguyen, Anna Pokpongkiat, Nolan N Djajadi, Stephanie Seth, Anmol Jung, Esther Chung, Esther O Jilek, Wendy Subramoney, Vishak Hafen, Ryan Häggström, Jonas Norman, Thea Brown, Kenneth H The Ki Child Growth Consortium |
| author_browse | Benjamin-Chung, Jade Brown, Kenneth H Cai, Wilson Chung, Esther O Colford Jr, John M Coyle, Jeremy Djajadi, Stephanie Hafen, Ryan Hejazi, Nima Hubbard, J. Alan E Häggström, Jonas Jilek, Wendy Jung, Esther Li, Haodong Malenica, Ivana Mertens, Andrew Nguyen, Anna Norman, Thea Pokpongkiat, Nolan N Rosete, Sonali Seth, Anmol Sofrygin, Oleg Subramoney, Vishak The Ki Child Growth Consortium van der Laan, Mark |
| author_facet | Mertens, Andrew Benjamin-Chung, Jade Colford Jr, John M Coyle, Jeremy van der Laan, Mark Hubbard, J. Alan E Rosete, Sonali Malenica, Ivana Hejazi, Nima Sofrygin, Oleg Cai, Wilson Li, Haodong Nguyen, Anna Pokpongkiat, Nolan N Djajadi, Stephanie Seth, Anmol Jung, Esther Chung, Esther O Jilek, Wendy Subramoney, Vishak Hafen, Ryan Häggström, Jonas Norman, Thea Brown, Kenneth H The Ki Child Growth Consortium |
| author_sort | Mertens, Andrew |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Growth faltering in children (low length for age or low weight for length) during the first 1,000 days of life (from conception to 2 years of age) influences short-term and long-term health and survival1,2. Interventions such as nutritional supplementation during pregnancy and the postnatal period could help prevent growth faltering, but programmatic action has been insufficient to eliminate the high burden of stunting and wasting in low- and middle-income countries. Identification of age windows and population subgroups on which to focus will benefit future preventive efforts. Here we use a population intervention effects analysis of 33 longitudinal cohorts (83,671 children, 662,763 measurements) and 30 separate exposures to show that improving maternal anthropometry and child condition at birth accounted for population increases in length-for-age z-scores of up to 0.40 and weight-for-length z-scores of up to 0.15 by 24 months of age. Boys had consistently higher risk of all forms of growth faltering than girls. Early postnatal growth faltering predisposed children to subsequent and persistent growth faltering. Children with multiple growth deficits exhibited higher mortality rates from birth to 2 years of age than children without growth deficits (hazard ratios 1.9 to 8.7). The importance of prenatal causes and severe consequences for children who experienced early growth faltering support a focus on pre-conception and pregnancy as a key opportunity for new preventive interventions. |
| format | Journal Article |
| id | CGSpace139385 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace1393852025-12-08T09:54:28Z Causes and consequences of child growth faltering in low-resource settings Mertens, Andrew Benjamin-Chung, Jade Colford Jr, John M Coyle, Jeremy van der Laan, Mark Hubbard, J. Alan E Rosete, Sonali Malenica, Ivana Hejazi, Nima Sofrygin, Oleg Cai, Wilson Li, Haodong Nguyen, Anna Pokpongkiat, Nolan N Djajadi, Stephanie Seth, Anmol Jung, Esther Chung, Esther O Jilek, Wendy Subramoney, Vishak Hafen, Ryan Häggström, Jonas Norman, Thea Brown, Kenneth H The Ki Child Growth Consortium child growth health stunting anthropometry Growth faltering in children (low length for age or low weight for length) during the first 1,000 days of life (from conception to 2 years of age) influences short-term and long-term health and survival1,2. Interventions such as nutritional supplementation during pregnancy and the postnatal period could help prevent growth faltering, but programmatic action has been insufficient to eliminate the high burden of stunting and wasting in low- and middle-income countries. Identification of age windows and population subgroups on which to focus will benefit future preventive efforts. Here we use a population intervention effects analysis of 33 longitudinal cohorts (83,671 children, 662,763 measurements) and 30 separate exposures to show that improving maternal anthropometry and child condition at birth accounted for population increases in length-for-age z-scores of up to 0.40 and weight-for-length z-scores of up to 0.15 by 24 months of age. Boys had consistently higher risk of all forms of growth faltering than girls. Early postnatal growth faltering predisposed children to subsequent and persistent growth faltering. Children with multiple growth deficits exhibited higher mortality rates from birth to 2 years of age than children without growth deficits (hazard ratios 1.9 to 8.7). The importance of prenatal causes and severe consequences for children who experienced early growth faltering support a focus on pre-conception and pregnancy as a key opportunity for new preventive interventions. 2023-09-21 2024-02-14T17:12:15Z 2024-02-14T17:12:15Z Journal Article https://hdl.handle.net/10568/139385 en Open Access Springer Mertens, Andrew; Benjamin-Chung, Jade; Colford Jr, John M.; Coyle, Jeremy; van der Laan, Mark; Hubbard, J. Alan E.; et al. 2023. Causes and consequences of child growth faltering in low-resource settings. Nature 621: 568-576. https://doi.org/10.1038/s41586-023-06501-x |
| spellingShingle | child growth health stunting anthropometry Mertens, Andrew Benjamin-Chung, Jade Colford Jr, John M Coyle, Jeremy van der Laan, Mark Hubbard, J. Alan E Rosete, Sonali Malenica, Ivana Hejazi, Nima Sofrygin, Oleg Cai, Wilson Li, Haodong Nguyen, Anna Pokpongkiat, Nolan N Djajadi, Stephanie Seth, Anmol Jung, Esther Chung, Esther O Jilek, Wendy Subramoney, Vishak Hafen, Ryan Häggström, Jonas Norman, Thea Brown, Kenneth H The Ki Child Growth Consortium Causes and consequences of child growth faltering in low-resource settings |
| title | Causes and consequences of child growth faltering in low-resource settings |
| title_full | Causes and consequences of child growth faltering in low-resource settings |
| title_fullStr | Causes and consequences of child growth faltering in low-resource settings |
| title_full_unstemmed | Causes and consequences of child growth faltering in low-resource settings |
| title_short | Causes and consequences of child growth faltering in low-resource settings |
| title_sort | causes and consequences of child growth faltering in low resource settings |
| topic | child growth health stunting anthropometry |
| url | https://hdl.handle.net/10568/139385 |
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