Complex traits and candidate genes: estimation of genetic variance components across multiple genetic architectures
Large-effect loci—those statistically significant loci discovered by genome-wide association studies or linkage mapping—associated with key traits segregate amidst a background of minor, often undetectable, genetic effects in wild and domesticated plants and animals. Accurately attributing mean diff...
| Autores principales: | , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
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Oxford University Press
2023
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| Acceso en línea: | https://hdl.handle.net/10568/132688 |
| _version_ | 1855522262876160000 |
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| author | Feldmann, Mitchell J. Covarrubias Pazaran, Giovanny Eduardo Piepho, Hans-Peter |
| author_browse | Covarrubias Pazaran, Giovanny Eduardo Feldmann, Mitchell J. Piepho, Hans-Peter |
| author_facet | Feldmann, Mitchell J. Covarrubias Pazaran, Giovanny Eduardo Piepho, Hans-Peter |
| author_sort | Feldmann, Mitchell J. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Large-effect loci—those statistically significant loci discovered by genome-wide association studies or linkage mapping—associated with key traits segregate amidst a background of minor, often undetectable, genetic effects in wild and domesticated plants and animals. Accurately attributing mean differences and variance explained to the correct components in the linear mixed model analysis is vital for selecting superior progeny and parents in plant and animal breeding, gene therapy, and medical genetics in humans. Marker-assisted prediction and its successor, genomic prediction, have many advantages for selecting superior individuals and understanding disease risk. However, these two approaches are less often integrated to study complex traits with different genetic architectures. This simulation study demonstrates that the average semivariance can be applied to models incorporating Mendelian, oligogenic, and polygenic terms simultaneously and yields accurate estimates of the variance explained for all relevant variables. Our previous research focused on largeeffect loci and polygenic variance separately. This work aims to synthesize and expand the average semivariance framework to various genetic architectures and the corresponding mixed models. This framework independently accounts for the effects of large-effect loci and the polygenic genetic background and is universally applicable to genetics studies in humans, plants, animals, and microbes. |
| format | Journal Article |
| id | CGSpace132688 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Oxford University Press |
| publisherStr | Oxford University Press |
| record_format | dspace |
| spelling | CGSpace1326882025-11-12T04:56:52Z Complex traits and candidate genes: estimation of genetic variance components across multiple genetic architectures Feldmann, Mitchell J. Covarrubias Pazaran, Giovanny Eduardo Piepho, Hans-Peter linear models polygenes mendelism genetic variance genes Large-effect loci—those statistically significant loci discovered by genome-wide association studies or linkage mapping—associated with key traits segregate amidst a background of minor, often undetectable, genetic effects in wild and domesticated plants and animals. Accurately attributing mean differences and variance explained to the correct components in the linear mixed model analysis is vital for selecting superior progeny and parents in plant and animal breeding, gene therapy, and medical genetics in humans. Marker-assisted prediction and its successor, genomic prediction, have many advantages for selecting superior individuals and understanding disease risk. However, these two approaches are less often integrated to study complex traits with different genetic architectures. This simulation study demonstrates that the average semivariance can be applied to models incorporating Mendelian, oligogenic, and polygenic terms simultaneously and yields accurate estimates of the variance explained for all relevant variables. Our previous research focused on largeeffect loci and polygenic variance separately. This work aims to synthesize and expand the average semivariance framework to various genetic architectures and the corresponding mixed models. This framework independently accounts for the effects of large-effect loci and the polygenic genetic background and is universally applicable to genetics studies in humans, plants, animals, and microbes. 2023-08-30 2023-11-03T06:39:38Z 2023-11-03T06:39:38Z Journal Article https://hdl.handle.net/10568/132688 en Open Access application/pdf Oxford University Press Feldmann, Mitchell J., Giovanny Covarrubias-Pazaran, and Hans-Peter Piepho. "Complex traits and candidate genes: estimation of genetic variance components across multiple genetic architectures." G3: Genes, Genomes, Genetics 13, no. 9 (2023): jkad148. |
| spellingShingle | linear models polygenes mendelism genetic variance genes Feldmann, Mitchell J. Covarrubias Pazaran, Giovanny Eduardo Piepho, Hans-Peter Complex traits and candidate genes: estimation of genetic variance components across multiple genetic architectures |
| title | Complex traits and candidate genes: estimation of genetic variance components across multiple genetic architectures |
| title_full | Complex traits and candidate genes: estimation of genetic variance components across multiple genetic architectures |
| title_fullStr | Complex traits and candidate genes: estimation of genetic variance components across multiple genetic architectures |
| title_full_unstemmed | Complex traits and candidate genes: estimation of genetic variance components across multiple genetic architectures |
| title_short | Complex traits and candidate genes: estimation of genetic variance components across multiple genetic architectures |
| title_sort | complex traits and candidate genes estimation of genetic variance components across multiple genetic architectures |
| topic | linear models polygenes mendelism genetic variance genes |
| url | https://hdl.handle.net/10568/132688 |
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