Seroprevalence of Brucella spp. and Rift Valley fever virus among slaughterhouse workers in Isiolo County, northern Kenya
Brucella spp. and Rift Valley fever virus (RVFV) are classified as priority zoonotic agents in Kenya, based on their public health and socioeconomic impact on the country. Data on the pathogen-specific and co-exposure levels is scarce due to limited active surveillance. This study investigated serop...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
2023
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| Online Access: | https://hdl.handle.net/10568/132158 |
| _version_ | 1855530408621375488 |
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| author | Nyamota, Richard Maina, J. Akoko, James M. Nthiwa, D. Mwatondo, Athman Muturi, Mathew Wambua, Lillian Middlebrook, E.A. Bartlow, A.W. Fair, J.M. Bett, Bernard K. |
| author_browse | Akoko, James M. Bartlow, A.W. Bett, Bernard K. Fair, J.M. Maina, J. Middlebrook, E.A. Muturi, Mathew Mwatondo, Athman Nthiwa, D. Nyamota, Richard Wambua, Lillian |
| author_facet | Nyamota, Richard Maina, J. Akoko, James M. Nthiwa, D. Mwatondo, Athman Muturi, Mathew Wambua, Lillian Middlebrook, E.A. Bartlow, A.W. Fair, J.M. Bett, Bernard K. |
| author_sort | Nyamota, Richard |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Brucella spp. and Rift Valley fever virus (RVFV) are classified as priority zoonotic agents in Kenya, based on their public health and socioeconomic impact on the country. Data on the pathogen-specific and co-exposure levels is scarce due to limited active surveillance. This study investigated seroprevalence and co-exposure of Brucella spp. and RVFV and associated risk factors among slaughterhouse workers in Isiolo County, northern Kenya. A cross-sectional serosurvey was done in all 19 slaughterhouses in Isiolo County, enrolling 378 participants into the study. The overall seroprevalences for Brucella spp. and RVFV were 40.2% (95% CI: 35.2–45.4) and 18.3% (95% CI: 14.5–22.5), respectively while 10.3% (95% CI 7.4%-13.8%) of individuals were positive for antibodies against both Brucella spp. and RVFV. Virus neutralisation tests (VNT) confirmed anti-RVFV antibodies in 85% of ELISA-positive samples. Our seroprevalence results were comparable to community-level seroprevalences previously reported in the area. Since most of the study participants were not from livestock-keeping households, our findings attribute most of the detected infections to occupational exposure. The high exposure levels indicate slaughterhouse workers are the most at-risk population and there is need for infection, prevention, and control programs among this high-risk group. This is the first VNT confirmation of virus-neutralising antibodies among slaughterhouse workers in Isiolo County and corroborates reports of the area being a high-risk RVFV area as occasioned by previously reported outbreaks. This necessitates sensitization campaigns to enhance awareness of the risks involved and appropriate mitigation measures. |
| format | Journal Article |
| id | CGSpace132158 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| record_format | dspace |
| spelling | CGSpace1321582025-10-26T12:52:39Z Seroprevalence of Brucella spp. and Rift Valley fever virus among slaughterhouse workers in Isiolo County, northern Kenya Nyamota, Richard Maina, J. Akoko, James M. Nthiwa, D. Mwatondo, Athman Muturi, Mathew Wambua, Lillian Middlebrook, E.A. Bartlow, A.W. Fair, J.M. Bett, Bernard K. brucellosis rift valley fever zoonoses health Brucella spp. and Rift Valley fever virus (RVFV) are classified as priority zoonotic agents in Kenya, based on their public health and socioeconomic impact on the country. Data on the pathogen-specific and co-exposure levels is scarce due to limited active surveillance. This study investigated seroprevalence and co-exposure of Brucella spp. and RVFV and associated risk factors among slaughterhouse workers in Isiolo County, northern Kenya. A cross-sectional serosurvey was done in all 19 slaughterhouses in Isiolo County, enrolling 378 participants into the study. The overall seroprevalences for Brucella spp. and RVFV were 40.2% (95% CI: 35.2–45.4) and 18.3% (95% CI: 14.5–22.5), respectively while 10.3% (95% CI 7.4%-13.8%) of individuals were positive for antibodies against both Brucella spp. and RVFV. Virus neutralisation tests (VNT) confirmed anti-RVFV antibodies in 85% of ELISA-positive samples. Our seroprevalence results were comparable to community-level seroprevalences previously reported in the area. Since most of the study participants were not from livestock-keeping households, our findings attribute most of the detected infections to occupational exposure. The high exposure levels indicate slaughterhouse workers are the most at-risk population and there is need for infection, prevention, and control programs among this high-risk group. This is the first VNT confirmation of virus-neutralising antibodies among slaughterhouse workers in Isiolo County and corroborates reports of the area being a high-risk RVFV area as occasioned by previously reported outbreaks. This necessitates sensitization campaigns to enhance awareness of the risks involved and appropriate mitigation measures. 2023-10-05 2023-10-06T10:03:10Z 2023-10-06T10:03:10Z Journal Article https://hdl.handle.net/10568/132158 en Open Access Nyamota, R., Maina, J., Akoko, J., Nthiwa, D., Mwatondo, A., Muturi, M., Wambua, L., Middlebrook, E.A., Bartlow, A.W., Fair, J.M. and Bett, B. 2023. Seroprevalence of Brucella spp. and Rift Valley fever virus among slaughterhouse workers in Isiolo County, northern Kenya. PLOS Neglected Tropical Diseases 17(10): e0011677. |
| spellingShingle | brucellosis rift valley fever zoonoses health Nyamota, Richard Maina, J. Akoko, James M. Nthiwa, D. Mwatondo, Athman Muturi, Mathew Wambua, Lillian Middlebrook, E.A. Bartlow, A.W. Fair, J.M. Bett, Bernard K. Seroprevalence of Brucella spp. and Rift Valley fever virus among slaughterhouse workers in Isiolo County, northern Kenya |
| title | Seroprevalence of Brucella spp. and Rift Valley fever virus among slaughterhouse workers in Isiolo County, northern Kenya |
| title_full | Seroprevalence of Brucella spp. and Rift Valley fever virus among slaughterhouse workers in Isiolo County, northern Kenya |
| title_fullStr | Seroprevalence of Brucella spp. and Rift Valley fever virus among slaughterhouse workers in Isiolo County, northern Kenya |
| title_full_unstemmed | Seroprevalence of Brucella spp. and Rift Valley fever virus among slaughterhouse workers in Isiolo County, northern Kenya |
| title_short | Seroprevalence of Brucella spp. and Rift Valley fever virus among slaughterhouse workers in Isiolo County, northern Kenya |
| title_sort | seroprevalence of brucella spp and rift valley fever virus among slaughterhouse workers in isiolo county northern kenya |
| topic | brucellosis rift valley fever zoonoses health |
| url | https://hdl.handle.net/10568/132158 |
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