Fate and transport modelling for evaluating antibiotic resistance in aquatic environments: Current knowledge and research priorities
Antibiotics have revolutionised medicine in the last century and enabled the prevention of bacterial infections that were previously deemed untreatable. However, in parallel, bacteria have increasingly developed resistance to antibiotics through various mechanisms. When resistant bacteria find their...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2024
|
| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/131839 |
| _version_ | 1855519299192487936 |
|---|---|
| author | Jampani, Mahesh Mateo-Sagasta, Javier Chandrasekar, A. Fatta-Kassinos, D. Graham, D.W. Gothwal, R. Moodley, Arshnee Mohan, Chadag V. Wiberg, David A. Langan, Simon J. |
| author_browse | Chandrasekar, A. Fatta-Kassinos, D. Gothwal, R. Graham, D.W. Jampani, Mahesh Langan, Simon J. Mateo-Sagasta, Javier Mohan, Chadag V. Moodley, Arshnee Wiberg, David A. |
| author_facet | Jampani, Mahesh Mateo-Sagasta, Javier Chandrasekar, A. Fatta-Kassinos, D. Graham, D.W. Gothwal, R. Moodley, Arshnee Mohan, Chadag V. Wiberg, David A. Langan, Simon J. |
| author_sort | Jampani, Mahesh |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Antibiotics have revolutionised medicine in the last century and enabled the prevention of bacterial infections that were previously deemed untreatable. However, in parallel, bacteria have increasingly developed resistance to antibiotics through various mechanisms. When resistant bacteria find their way into terrestrial and aquatic environments, animal and human exposures increase, e.g., via polluted soil, food, and water, and health risks multiply. Understanding the fate and transport of antibiotic resistant bacteria (ARB) and the transfer mechanisms of antibiotic resistance genes (ARGs) in aquatic environments is critical for evaluating and mitigating the risks of resistant-induced infections. The conceptual understanding of sources and pathways of antibiotics, ARB, and ARGs from society to the water environments is essential for setting the scene and developing an appropriate framework for modelling. Various factors and processes associated with hydrology, ecology, and climate change can significantly affect the fate and transport of ARB and ARGs in natural environments. This article reviews current knowledge, research gaps, and priorities for developing water quality models to assess the fate and transport of ARB and ARGs. The paper also provides inputs on future research needs, especially the need for new predictive models to guide risk assessment on AR transmission and spread in aquatic environments. |
| format | Journal Article |
| id | CGSpace131839 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2024 |
| publishDateRange | 2024 |
| publishDateSort | 2024 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace1318392025-10-26T12:54:40Z Fate and transport modelling for evaluating antibiotic resistance in aquatic environments: Current knowledge and research priorities Jampani, Mahesh Mateo-Sagasta, Javier Chandrasekar, A. Fatta-Kassinos, D. Graham, D.W. Gothwal, R. Moodley, Arshnee Mohan, Chadag V. Wiberg, David A. Langan, Simon J. antimicrobial resistance aquatic environment modelling water pollution environmental engineering Antibiotics have revolutionised medicine in the last century and enabled the prevention of bacterial infections that were previously deemed untreatable. However, in parallel, bacteria have increasingly developed resistance to antibiotics through various mechanisms. When resistant bacteria find their way into terrestrial and aquatic environments, animal and human exposures increase, e.g., via polluted soil, food, and water, and health risks multiply. Understanding the fate and transport of antibiotic resistant bacteria (ARB) and the transfer mechanisms of antibiotic resistance genes (ARGs) in aquatic environments is critical for evaluating and mitigating the risks of resistant-induced infections. The conceptual understanding of sources and pathways of antibiotics, ARB, and ARGs from society to the water environments is essential for setting the scene and developing an appropriate framework for modelling. Various factors and processes associated with hydrology, ecology, and climate change can significantly affect the fate and transport of ARB and ARGs in natural environments. This article reviews current knowledge, research gaps, and priorities for developing water quality models to assess the fate and transport of ARB and ARGs. The paper also provides inputs on future research needs, especially the need for new predictive models to guide risk assessment on AR transmission and spread in aquatic environments. 2024-01 2023-09-13T08:58:12Z 2023-09-13T08:58:12Z Journal Article https://hdl.handle.net/10568/131839 en https://ars.els-cdn.com/content/image/1-s2.0-S0304389423018101-mmc1.pdf Open Access Elsevier Jampani, M., Mateo-Sagasta, J., Chandrasekar, A., Fatta-Kassinos, D., Graham, D.W., Gothwal, R., Moodley, A., Chadag, V.M., Wiberg, D. and Langan, S. 2024. Fate and transport modelling for evaluating antibiotic resistance in aquatic environments: Current knowledge and research priorities. <i>Journal of Hazardous Materials</i> 461: 132527. |
| spellingShingle | antimicrobial resistance aquatic environment modelling water pollution environmental engineering Jampani, Mahesh Mateo-Sagasta, Javier Chandrasekar, A. Fatta-Kassinos, D. Graham, D.W. Gothwal, R. Moodley, Arshnee Mohan, Chadag V. Wiberg, David A. Langan, Simon J. Fate and transport modelling for evaluating antibiotic resistance in aquatic environments: Current knowledge and research priorities |
| title | Fate and transport modelling for evaluating antibiotic resistance in aquatic environments: Current knowledge and research priorities |
| title_full | Fate and transport modelling for evaluating antibiotic resistance in aquatic environments: Current knowledge and research priorities |
| title_fullStr | Fate and transport modelling for evaluating antibiotic resistance in aquatic environments: Current knowledge and research priorities |
| title_full_unstemmed | Fate and transport modelling for evaluating antibiotic resistance in aquatic environments: Current knowledge and research priorities |
| title_short | Fate and transport modelling for evaluating antibiotic resistance in aquatic environments: Current knowledge and research priorities |
| title_sort | fate and transport modelling for evaluating antibiotic resistance in aquatic environments current knowledge and research priorities |
| topic | antimicrobial resistance aquatic environment modelling water pollution environmental engineering |
| url | https://hdl.handle.net/10568/131839 |
| work_keys_str_mv | AT jampanimahesh fateandtransportmodellingforevaluatingantibioticresistanceinaquaticenvironmentscurrentknowledgeandresearchpriorities AT mateosagastajavier fateandtransportmodellingforevaluatingantibioticresistanceinaquaticenvironmentscurrentknowledgeandresearchpriorities AT chandrasekara fateandtransportmodellingforevaluatingantibioticresistanceinaquaticenvironmentscurrentknowledgeandresearchpriorities AT fattakassinosd fateandtransportmodellingforevaluatingantibioticresistanceinaquaticenvironmentscurrentknowledgeandresearchpriorities AT grahamdw fateandtransportmodellingforevaluatingantibioticresistanceinaquaticenvironmentscurrentknowledgeandresearchpriorities AT gothwalr fateandtransportmodellingforevaluatingantibioticresistanceinaquaticenvironmentscurrentknowledgeandresearchpriorities AT moodleyarshnee fateandtransportmodellingforevaluatingantibioticresistanceinaquaticenvironmentscurrentknowledgeandresearchpriorities AT mohanchadagv fateandtransportmodellingforevaluatingantibioticresistanceinaquaticenvironmentscurrentknowledgeandresearchpriorities AT wibergdavida fateandtransportmodellingforevaluatingantibioticresistanceinaquaticenvironmentscurrentknowledgeandresearchpriorities AT langansimonj fateandtransportmodellingforevaluatingantibioticresistanceinaquaticenvironmentscurrentknowledgeandresearchpriorities |