Epidemiological connectivity between humans and animals across an urban landscape
Urbanization is predicted to be a key driver of disease emergence through human exposure to novel, animal-borne pathogens. However, while we suspect that urban landscapes are primed to expose people to novel animal-borne diseases, evidence for the mechanisms by which this occurs is lacking. To addre...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
National Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/131165 |
| _version_ | 1855541484939378688 |
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| author | Hassell, James M. Muloi, Dishon M. VanderWaal, K.L. Ward, M.J. Bettridge, Judy M. Gitahi, N. Ouko, T. Imboma, Titus Akoko, James M. Karani, Maurice K. Muinde, Patrick Nakamura, Y. Alumasa, Lorren Furmaga, E. Kaitho, T. Amanya, Fredrick Ogendo, Allan Fava, Francesco P. Wee, B.A. Phan, H. Kiiru, J. Kang'ethe, Erastus K. Kariuki, S. Robinson, T. Begon, M. Woolhouse, Mark E.J. Fèvre, Eric M. |
| author_browse | Akoko, James M. Alumasa, Lorren Amanya, Fredrick Begon, M. Bettridge, Judy M. Fava, Francesco P. Furmaga, E. Fèvre, Eric M. Gitahi, N. Hassell, James M. Imboma, Titus Kaitho, T. Kang'ethe, Erastus K. Karani, Maurice K. Kariuki, S. Kiiru, J. Muinde, Patrick Muloi, Dishon M. Nakamura, Y. Ogendo, Allan Ouko, T. Phan, H. Robinson, T. VanderWaal, K.L. Ward, M.J. Wee, B.A. Woolhouse, Mark E.J. |
| author_facet | Hassell, James M. Muloi, Dishon M. VanderWaal, K.L. Ward, M.J. Bettridge, Judy M. Gitahi, N. Ouko, T. Imboma, Titus Akoko, James M. Karani, Maurice K. Muinde, Patrick Nakamura, Y. Alumasa, Lorren Furmaga, E. Kaitho, T. Amanya, Fredrick Ogendo, Allan Fava, Francesco P. Wee, B.A. Phan, H. Kiiru, J. Kang'ethe, Erastus K. Kariuki, S. Robinson, T. Begon, M. Woolhouse, Mark E.J. Fèvre, Eric M. |
| author_sort | Hassell, James M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Urbanization is predicted to be a key driver of disease emergence through human exposure to novel, animal-borne pathogens. However, while we suspect that urban landscapes are primed to expose people to novel animal-borne diseases, evidence for the mechanisms by which this occurs is lacking. To address this, we studied how bacterial genes are shared between wild animals, livestock, and humans (n = 1,428) across Nairobi, Kenya—one of the world’s most rapidly developing cities. Applying a multilayer network framework, we show that low biodiversity (of both natural habitat and vertebrate wildlife communities), coupled with livestock management practices and more densely populated urban environments, promotes sharing of Escherichia coli–borne bacterial mobile genetic elements between animals and humans. These results provide empirical support for hypotheses linking resource provision, the biological simplification of urban landscapes, and human and livestock demography to urban dynamics of cross-species pathogen transmission at a landscape scale. Urban areas where high densities of people and livestock live in close association with synanthropes (species such as rodents that are more competent reservoirs for zoonotic pathogens) should be prioritized for disease surveillance and control. |
| format | Journal Article |
| id | CGSpace131165 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | National Academy of Sciences |
| publisherStr | National Academy of Sciences |
| record_format | dspace |
| spelling | CGSpace1311652025-10-26T12:50:50Z Epidemiological connectivity between humans and animals across an urban landscape Hassell, James M. Muloi, Dishon M. VanderWaal, K.L. Ward, M.J. Bettridge, Judy M. Gitahi, N. Ouko, T. Imboma, Titus Akoko, James M. Karani, Maurice K. Muinde, Patrick Nakamura, Y. Alumasa, Lorren Furmaga, E. Kaitho, T. Amanya, Fredrick Ogendo, Allan Fava, Francesco P. Wee, B.A. Phan, H. Kiiru, J. Kang'ethe, Erastus K. Kariuki, S. Robinson, T. Begon, M. Woolhouse, Mark E.J. Fèvre, Eric M. epidemiology zoonoses animal health health wildlife one health approach urbanization Urbanization is predicted to be a key driver of disease emergence through human exposure to novel, animal-borne pathogens. However, while we suspect that urban landscapes are primed to expose people to novel animal-borne diseases, evidence for the mechanisms by which this occurs is lacking. To address this, we studied how bacterial genes are shared between wild animals, livestock, and humans (n = 1,428) across Nairobi, Kenya—one of the world’s most rapidly developing cities. Applying a multilayer network framework, we show that low biodiversity (of both natural habitat and vertebrate wildlife communities), coupled with livestock management practices and more densely populated urban environments, promotes sharing of Escherichia coli–borne bacterial mobile genetic elements between animals and humans. These results provide empirical support for hypotheses linking resource provision, the biological simplification of urban landscapes, and human and livestock demography to urban dynamics of cross-species pathogen transmission at a landscape scale. Urban areas where high densities of people and livestock live in close association with synanthropes (species such as rodents that are more competent reservoirs for zoonotic pathogens) should be prioritized for disease surveillance and control. 2023-07-18 2023-07-17T07:23:06Z 2023-07-17T07:23:06Z Journal Article https://hdl.handle.net/10568/131165 en Open Access National Academy of Sciences Hassell, J.M., Muloi, D.M., VanderWaal, K.L., Ward, M.J., Bettridge, J., Gitahi, N., Ouko, T., Imboma, T., Akoko, J., Karani, M., Muinde, P., Nakamura, Y., Alumasa, L., Furmaga, E., Kaitho, T., Amanya, F., Ogendo, A., Fava, F., Wee, B.A., Phan, H., Kiiru, J., Kang'ethe, E., Kariuki, S., Robinson, T., Begon, M., Woolhouse, M.E.J. and Fèvre, E.M. 2023. Epidemiological connectivity between humans and animals across an urban landscape. Proceedings of the National Academy of Sciences of the United States of America 120(29): e2218860120. |
| spellingShingle | epidemiology zoonoses animal health health wildlife one health approach urbanization Hassell, James M. Muloi, Dishon M. VanderWaal, K.L. Ward, M.J. Bettridge, Judy M. Gitahi, N. Ouko, T. Imboma, Titus Akoko, James M. Karani, Maurice K. Muinde, Patrick Nakamura, Y. Alumasa, Lorren Furmaga, E. Kaitho, T. Amanya, Fredrick Ogendo, Allan Fava, Francesco P. Wee, B.A. Phan, H. Kiiru, J. Kang'ethe, Erastus K. Kariuki, S. Robinson, T. Begon, M. Woolhouse, Mark E.J. Fèvre, Eric M. Epidemiological connectivity between humans and animals across an urban landscape |
| title | Epidemiological connectivity between humans and animals across an urban landscape |
| title_full | Epidemiological connectivity between humans and animals across an urban landscape |
| title_fullStr | Epidemiological connectivity between humans and animals across an urban landscape |
| title_full_unstemmed | Epidemiological connectivity between humans and animals across an urban landscape |
| title_short | Epidemiological connectivity between humans and animals across an urban landscape |
| title_sort | epidemiological connectivity between humans and animals across an urban landscape |
| topic | epidemiology zoonoses animal health health wildlife one health approach urbanization |
| url | https://hdl.handle.net/10568/131165 |
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