Pathobiological analysis of African swine fever virus contact-exposed pigs and estimation of the basic reproduction number of the virus in Vietnam
Background African swine fever (ASF), caused by African swine fever virus (ASFV), is a fatal disease affecting wild and domestic pigs. Since China reported the first ASF outbreak in August 2018, ASFV has swept over the neighbouring Asian countries. However, studies involving experimental pig-to-pig...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Springer
2023
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/130980 |
| _version_ | 1855518922554474496 |
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| author | Sang-Ik Oh Ngoc Anh Bui Vuong Nghia Bui Duy Tung Dao Ara Cho Han Gyu Lee Young-Hun Jung Yoon Jung Do Eunju Kim Eun-Yeong Bok Tai-Young Hur Hu Suk Lee |
| author_browse | Ara Cho Duy Tung Dao Eun-Yeong Bok Eunju Kim Han Gyu Lee Hu Suk Lee Ngoc Anh Bui Sang-Ik Oh Tai-Young Hur Vuong Nghia Bui Yoon Jung Do Young-Hun Jung |
| author_facet | Sang-Ik Oh Ngoc Anh Bui Vuong Nghia Bui Duy Tung Dao Ara Cho Han Gyu Lee Young-Hun Jung Yoon Jung Do Eunju Kim Eun-Yeong Bok Tai-Young Hur Hu Suk Lee |
| author_sort | Sang-Ik Oh |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Background
African swine fever (ASF), caused by African swine fever virus (ASFV), is a fatal disease affecting wild and domestic pigs. Since China reported the first ASF outbreak in August 2018, ASFV has swept over the neighbouring Asian countries. However, studies involving experimental pig-to-pig ASFV transmission in Vietnam are lacking. The main objective of this experimental study was to demonstrate the pathobiological characteristics of ASFV contact-exposed pigs and estimate their basic reproduction number (R0) in Vietnam. Fifteen pigs were randomly divided into two groups: experimental (n = 10) and negative control (n = 5) groups. One pig in the experimental group was intramuscularly inoculated with ASFV strain from Vietnam in 2020 and housed with the uninoculated pigs during the study period (28 days).
Results
The inoculated pig died 6 days post-inoculation, and the final survival rate was 90.0%. We started observing viremia and excretion of ASFV 10 days post-exposure in contact-exposed pigs. Unlike the surviving and negative control pigs, all necropsied pigs showed severe congestive splenomegaly and moderate-to-severe haemorrhagic lesions in the lymph nodes. The surviving pig presented with mild haemorrhagic lesions in the spleen and kidneys. We used Susceptible-Infectious-Removed models for estimating R0. The R0 values for exponential growth (EG) and maximum likelihood (ML) were calculated to be 2.916 and 4.015, respectively. In addition, the transmission rates (β) were estimated to be 0.729 (95% confidence interval [CI]: 0.379–1.765) for EG and 1.004 (95% CI: 0.283–2.450) for ML.
Conclusions
This study revealed pathobiological and epidemiological information in about pig-to-pig ASFV transmission. Our findings suggested that culling infected herds within a brief period of time may mitigate the spread of ASF outbreaks. |
| format | Journal Article |
| id | CGSpace130980 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace1309802025-01-27T15:00:52Z Pathobiological analysis of African swine fever virus contact-exposed pigs and estimation of the basic reproduction number of the virus in Vietnam Sang-Ik Oh Ngoc Anh Bui Vuong Nghia Bui Duy Tung Dao Ara Cho Han Gyu Lee Young-Hun Jung Yoon Jung Do Eunju Kim Eun-Yeong Bok Tai-Young Hur Hu Suk Lee african swine fever swine epidemiology Background African swine fever (ASF), caused by African swine fever virus (ASFV), is a fatal disease affecting wild and domestic pigs. Since China reported the first ASF outbreak in August 2018, ASFV has swept over the neighbouring Asian countries. However, studies involving experimental pig-to-pig ASFV transmission in Vietnam are lacking. The main objective of this experimental study was to demonstrate the pathobiological characteristics of ASFV contact-exposed pigs and estimate their basic reproduction number (R0) in Vietnam. Fifteen pigs were randomly divided into two groups: experimental (n = 10) and negative control (n = 5) groups. One pig in the experimental group was intramuscularly inoculated with ASFV strain from Vietnam in 2020 and housed with the uninoculated pigs during the study period (28 days). Results The inoculated pig died 6 days post-inoculation, and the final survival rate was 90.0%. We started observing viremia and excretion of ASFV 10 days post-exposure in contact-exposed pigs. Unlike the surviving and negative control pigs, all necropsied pigs showed severe congestive splenomegaly and moderate-to-severe haemorrhagic lesions in the lymph nodes. The surviving pig presented with mild haemorrhagic lesions in the spleen and kidneys. We used Susceptible-Infectious-Removed models for estimating R0. The R0 values for exponential growth (EG) and maximum likelihood (ML) were calculated to be 2.916 and 4.015, respectively. In addition, the transmission rates (β) were estimated to be 0.729 (95% confidence interval [CI]: 0.379–1.765) for EG and 1.004 (95% CI: 0.283–2.450) for ML. Conclusions This study revealed pathobiological and epidemiological information in about pig-to-pig ASFV transmission. Our findings suggested that culling infected herds within a brief period of time may mitigate the spread of ASF outbreaks. 2023-06-30 2023-07-04T10:02:45Z 2023-07-04T10:02:45Z Journal Article https://hdl.handle.net/10568/130980 en Open Access Springer Sang-Ik Oh, Ngoc Anh Bui, Vuong Nghia Bui, Duy Tung Dao, Ara Cho, Han Gyu Lee, Young-Hun Jung, Yoon Jung Do, Eunju Kim, Eun-Yeong Bok, Tai-Young Hur and Hu Suk Lee. 2023. Pathobiological analysis of African swine fever virus contact-exposed pigs and estimation of the basic reproduction number of the virus in Vietnam. Porcine Health Management 9: 30. |
| spellingShingle | african swine fever swine epidemiology Sang-Ik Oh Ngoc Anh Bui Vuong Nghia Bui Duy Tung Dao Ara Cho Han Gyu Lee Young-Hun Jung Yoon Jung Do Eunju Kim Eun-Yeong Bok Tai-Young Hur Hu Suk Lee Pathobiological analysis of African swine fever virus contact-exposed pigs and estimation of the basic reproduction number of the virus in Vietnam |
| title | Pathobiological analysis of African swine fever virus contact-exposed pigs and estimation of the basic reproduction number of the virus in Vietnam |
| title_full | Pathobiological analysis of African swine fever virus contact-exposed pigs and estimation of the basic reproduction number of the virus in Vietnam |
| title_fullStr | Pathobiological analysis of African swine fever virus contact-exposed pigs and estimation of the basic reproduction number of the virus in Vietnam |
| title_full_unstemmed | Pathobiological analysis of African swine fever virus contact-exposed pigs and estimation of the basic reproduction number of the virus in Vietnam |
| title_short | Pathobiological analysis of African swine fever virus contact-exposed pigs and estimation of the basic reproduction number of the virus in Vietnam |
| title_sort | pathobiological analysis of african swine fever virus contact exposed pigs and estimation of the basic reproduction number of the virus in vietnam |
| topic | african swine fever swine epidemiology |
| url | https://hdl.handle.net/10568/130980 |
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