Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons
An international multidisciplinary consortium is conducting a programme of research on the host response to trypanosome infection. This builds upon quantitative trait loci (QTL) mapping which identified genome regions influencing susceptibility to pathology following T. congolense infection in both...
| Autores principales: | , , , , , , , , |
|---|---|
| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
2008
|
| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/1307 |
| _version_ | 1855540633949700096 |
|---|---|
| author | Kemp, Stephen J. Hanotte, Olivier H. Agaba, Morris Noyes, H.A. Gibson, John P. Archibald, A.L. Rennie, C. Hulme, H. Brass, A. |
| author_browse | Agaba, Morris Archibald, A.L. Brass, A. Gibson, John P. Hanotte, Olivier H. Hulme, H. Kemp, Stephen J. Noyes, H.A. Rennie, C. |
| author_facet | Kemp, Stephen J. Hanotte, Olivier H. Agaba, Morris Noyes, H.A. Gibson, John P. Archibald, A.L. Rennie, C. Hulme, H. Brass, A. |
| author_sort | Kemp, Stephen J. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | An international multidisciplinary consortium is conducting a programme of research on the host response to trypanosome infection. This builds upon quantitative trait loci (QTL) mapping which identified genome regions influencing susceptibility to pathology following T. congolense infection in both cattle and mice. The approach uses expression analysis to examine the response of both susceptible and resistant strains and a series of novel informatics tools to identify pathways which are activated as a result of challenge, and those which are differentially used by resistant and susceptible strains. Of particular interest are those pathways which simultaneously satisfy both criteria, i.e. are significantly differentially activated and contain genes within QTL regions. However, it is important to stress that it is not required that the genes within the QTL region are differentially expressed themselves. |
| format | Journal Article |
| id | CGSpace1307 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2008 |
| publishDateRange | 2008 |
| publishDateSort | 2008 |
| record_format | dspace |
| spelling | CGSpace13072023-04-20T00:29:35Z Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons Kemp, Stephen J. Hanotte, Olivier H. Agaba, Morris Noyes, H.A. Gibson, John P. Archibald, A.L. Rennie, C. Hulme, H. Brass, A. trypanosomosis animal diseases An international multidisciplinary consortium is conducting a programme of research on the host response to trypanosome infection. This builds upon quantitative trait loci (QTL) mapping which identified genome regions influencing susceptibility to pathology following T. congolense infection in both cattle and mice. The approach uses expression analysis to examine the response of both susceptible and resistant strains and a series of novel informatics tools to identify pathways which are activated as a result of challenge, and those which are differentially used by resistant and susceptible strains. Of particular interest are those pathways which simultaneously satisfy both criteria, i.e. are significantly differentially activated and contain genes within QTL regions. However, it is important to stress that it is not required that the genes within the QTL region are differentially expressed themselves. 2008 2010-04-21T12:40:18Z 2010-04-21T12:40:18Z Journal Article https://hdl.handle.net/10568/1307 en Limited Access Kemp, S.J.; Hanotte, O.; Agaba, M.; Noyes, H.A.; Gibson, J.; Archibald, A.; Rennie, C.; Hulme, H.; Brass, A. 2008. Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons . Developments in Biologicals 132:89-91. |
| spellingShingle | trypanosomosis animal diseases Kemp, Stephen J. Hanotte, Olivier H. Agaba, Morris Noyes, H.A. Gibson, John P. Archibald, A.L. Rennie, C. Hulme, H. Brass, A. Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons |
| title | Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons |
| title_full | Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons |
| title_fullStr | Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons |
| title_full_unstemmed | Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons |
| title_short | Genomics approaches to study the biology underlying resistance to trypanosomiasis--some unexpected lessons |
| title_sort | genomics approaches to study the biology underlying resistance to trypanosomiasis some unexpected lessons |
| topic | trypanosomosis animal diseases |
| url | https://hdl.handle.net/10568/1307 |
| work_keys_str_mv | AT kempstephenj genomicsapproachestostudythebiologyunderlyingresistancetotrypanosomiasissomeunexpectedlessons AT hanotteolivierh genomicsapproachestostudythebiologyunderlyingresistancetotrypanosomiasissomeunexpectedlessons AT agabamorris genomicsapproachestostudythebiologyunderlyingresistancetotrypanosomiasissomeunexpectedlessons AT noyesha genomicsapproachestostudythebiologyunderlyingresistancetotrypanosomiasissomeunexpectedlessons AT gibsonjohnp genomicsapproachestostudythebiologyunderlyingresistancetotrypanosomiasissomeunexpectedlessons AT archibaldal genomicsapproachestostudythebiologyunderlyingresistancetotrypanosomiasissomeunexpectedlessons AT renniec genomicsapproachestostudythebiologyunderlyingresistancetotrypanosomiasissomeunexpectedlessons AT hulmeh genomicsapproachestostudythebiologyunderlyingresistancetotrypanosomiasissomeunexpectedlessons AT brassa genomicsapproachestostudythebiologyunderlyingresistancetotrypanosomiasissomeunexpectedlessons |