Hybrids of RNA viruses and viroid-like elements replicate in fungi
Earth’s lifemay have originated as self-replicating RNA, and it has been argued that RNA viruses and viroid-like elements are remnants of such pre-cellular RNA world. RNA viruses are defined by linear RNA genomes encoding an RNAdependent RNA polymerase (RdRp), whereas viroid-like elements consist of...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Springer
2023
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/130469 |
| _version_ | 1855532278517596160 |
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| author | Forgia, M. Navarro, B. Daghino, S. Cervera, A. Gisel, A. Perotto, S. Aghayeva, D.N. Akinyuwa, M.F. Gobbi, E. Zheludev, I.N. Edgar, R.C. Chikhi, R. Turina, M. Babaian, A. Serio, F. di Peña, M. de la |
| author_browse | Aghayeva, D.N. Akinyuwa, M.F. Babaian, A. Cervera, A. Chikhi, R. Daghino, S. Edgar, R.C. Forgia, M. Gisel, A. Gobbi, E. Navarro, B. Perotto, S. Peña, M. de la Serio, F. di Turina, M. Zheludev, I.N. |
| author_facet | Forgia, M. Navarro, B. Daghino, S. Cervera, A. Gisel, A. Perotto, S. Aghayeva, D.N. Akinyuwa, M.F. Gobbi, E. Zheludev, I.N. Edgar, R.C. Chikhi, R. Turina, M. Babaian, A. Serio, F. di Peña, M. de la |
| author_sort | Forgia, M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Earth’s lifemay have originated as self-replicating RNA, and it has been argued that RNA viruses and viroid-like elements are remnants of such pre-cellular RNA world. RNA viruses are defined by linear RNA genomes encoding an RNAdependent RNA polymerase (RdRp), whereas viroid-like elements consist of small, single-stranded, circular RNA genomes that, in some cases, encode paired self-cleaving ribozymes. Here we show that the number of candidate viroid-like elements occurring in geographically and ecologically diverse niches is much higher than previously thought. We report that, amongst these circular genomes, fungal ambiviruses are viroid-like elements that undergo rolling circle replication and encode their own viral RdRp. Thus, ambiviruses are distinct infectious RNAs showing hybrid features of viroid-like RNAs and viruses. We also detected similar circular RNAs, containing active ribozymes and encoding RdRps, related to mitochondrial-like fungal viruses, highlighting fungi as an evolutionary hub for RNA viruses and viroid-like elements. Our findings point to a deep co-evolutionary history between RNA viruses and subviral elements and offer new perspectives in the origin and evolution of primordial infectious agents, and RNA life. |
| format | Journal Article |
| id | CGSpace130469 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace1304692025-12-08T10:04:27Z Hybrids of RNA viruses and viroid-like elements replicate in fungi Forgia, M. Navarro, B. Daghino, S. Cervera, A. Gisel, A. Perotto, S. Aghayeva, D.N. Akinyuwa, M.F. Gobbi, E. Zheludev, I.N. Edgar, R.C. Chikhi, R. Turina, M. Babaian, A. Serio, F. di Peña, M. de la rna viruses genomes fungi Earth’s lifemay have originated as self-replicating RNA, and it has been argued that RNA viruses and viroid-like elements are remnants of such pre-cellular RNA world. RNA viruses are defined by linear RNA genomes encoding an RNAdependent RNA polymerase (RdRp), whereas viroid-like elements consist of small, single-stranded, circular RNA genomes that, in some cases, encode paired self-cleaving ribozymes. Here we show that the number of candidate viroid-like elements occurring in geographically and ecologically diverse niches is much higher than previously thought. We report that, amongst these circular genomes, fungal ambiviruses are viroid-like elements that undergo rolling circle replication and encode their own viral RdRp. Thus, ambiviruses are distinct infectious RNAs showing hybrid features of viroid-like RNAs and viruses. We also detected similar circular RNAs, containing active ribozymes and encoding RdRps, related to mitochondrial-like fungal viruses, highlighting fungi as an evolutionary hub for RNA viruses and viroid-like elements. Our findings point to a deep co-evolutionary history between RNA viruses and subviral elements and offer new perspectives in the origin and evolution of primordial infectious agents, and RNA life. 2023 2023-05-23T07:47:07Z 2023-05-23T07:47:07Z Journal Article https://hdl.handle.net/10568/130469 en Open Access application/pdf Springer Forgia, M., Navarro, B., Daghino, S., Cervera, A., Gisel, A., Perotto, S., ... & de la Peña, M. (2023). Hybrids of RNA viruses and viroid-like elements replicate in fungi. Nature Communications, 14: 2591, 1-11. |
| spellingShingle | rna viruses genomes fungi Forgia, M. Navarro, B. Daghino, S. Cervera, A. Gisel, A. Perotto, S. Aghayeva, D.N. Akinyuwa, M.F. Gobbi, E. Zheludev, I.N. Edgar, R.C. Chikhi, R. Turina, M. Babaian, A. Serio, F. di Peña, M. de la Hybrids of RNA viruses and viroid-like elements replicate in fungi |
| title | Hybrids of RNA viruses and viroid-like elements replicate in fungi |
| title_full | Hybrids of RNA viruses and viroid-like elements replicate in fungi |
| title_fullStr | Hybrids of RNA viruses and viroid-like elements replicate in fungi |
| title_full_unstemmed | Hybrids of RNA viruses and viroid-like elements replicate in fungi |
| title_short | Hybrids of RNA viruses and viroid-like elements replicate in fungi |
| title_sort | hybrids of rna viruses and viroid like elements replicate in fungi |
| topic | rna viruses genomes fungi |
| url | https://hdl.handle.net/10568/130469 |
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