Molecular epidemiology and diversity of SARS-CoV-2 in Ethiopia, 2020–2022
Ethiopia is the second most populous country in Africa and the sixth most affected by COVID-19 on the continent. Despite having experienced five infection waves, >499,000 cases, and ~7500 COVID-19-related deaths as of January 2023, there is still no detailed genomic epidemiological report on the int...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
MDPI
2023
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/129697 |
| _version_ | 1855543515738537984 |
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| author | Sisay, A. Tshiabuila, D. Wyk, S. van Tesfaye, A. Mboowa, G. Oyola, Samuel O. Tesema, S.K. Baxter, C. Martin, D. Lessells, R. Tegally, H. Moir, M. Giandhari, J. Pillay, S. Singh, L. Ramphal, Y. Maharaj, A. Pillay, Y. Naidoo, Y. Ramphal, U. Chabuka, L. Wilkinson, E. Oliveira, T. de Desta, A.F. San, J.E. |
| author_browse | Baxter, C. Chabuka, L. Desta, A.F. Giandhari, J. Lessells, R. Maharaj, A. Martin, D. Mboowa, G. Moir, M. Naidoo, Y. Oliveira, T. de Oyola, Samuel O. Pillay, S. Pillay, Y. Ramphal, U. Ramphal, Y. San, J.E. Singh, L. Sisay, A. Tegally, H. Tesema, S.K. Tesfaye, A. Tshiabuila, D. Wilkinson, E. Wyk, S. van |
| author_facet | Sisay, A. Tshiabuila, D. Wyk, S. van Tesfaye, A. Mboowa, G. Oyola, Samuel O. Tesema, S.K. Baxter, C. Martin, D. Lessells, R. Tegally, H. Moir, M. Giandhari, J. Pillay, S. Singh, L. Ramphal, Y. Maharaj, A. Pillay, Y. Naidoo, Y. Ramphal, U. Chabuka, L. Wilkinson, E. Oliveira, T. de Desta, A.F. San, J.E. |
| author_sort | Sisay, A. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Ethiopia is the second most populous country in Africa and the sixth most affected by COVID-19 on the continent. Despite having experienced five infection waves, >499,000 cases, and ~7500 COVID-19-related deaths as of January 2023, there is still no detailed genomic epidemiological report on the introduction and spread of SARS-CoV-2 in Ethiopia. In this study, we reconstructed and elucidated the COVID-19 epidemic dynamics. Specifically, we investigated the introduction, local transmission, ongoing evolution, and spread of SARS-CoV-2 during the first four infection waves using 353 high-quality near-whole genomes sampled in Ethiopia. Our results show that whereas viral introductions seeded the first wave, subsequent waves were seeded by local transmission. The B.1.480 lineage emerged in the first wave and notably remained in circulation even after the emergence of the Alpha variant. The B.1.480 was outcompeted by the Delta variant. Notably, Ethiopia’s lack of local sequencing capacity was further limited by sporadic, uneven, and insufficient sampling that limited the incorporation of genomic epidemiology in the epidemic public health response in Ethiopia. These results highlight Ethiopia’s role in SARS-CoV-2 dissemination and the urgent need for balanced, near-real-time genomic sequencing. |
| format | Journal Article |
| id | CGSpace129697 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | CGSpace1296972025-12-08T10:29:22Z Molecular epidemiology and diversity of SARS-CoV-2 in Ethiopia, 2020–2022 Sisay, A. Tshiabuila, D. Wyk, S. van Tesfaye, A. Mboowa, G. Oyola, Samuel O. Tesema, S.K. Baxter, C. Martin, D. Lessells, R. Tegally, H. Moir, M. Giandhari, J. Pillay, S. Singh, L. Ramphal, Y. Maharaj, A. Pillay, Y. Naidoo, Y. Ramphal, U. Chabuka, L. Wilkinson, E. Oliveira, T. de Desta, A.F. San, J.E. covid-19 health epidemiology Ethiopia is the second most populous country in Africa and the sixth most affected by COVID-19 on the continent. Despite having experienced five infection waves, >499,000 cases, and ~7500 COVID-19-related deaths as of January 2023, there is still no detailed genomic epidemiological report on the introduction and spread of SARS-CoV-2 in Ethiopia. In this study, we reconstructed and elucidated the COVID-19 epidemic dynamics. Specifically, we investigated the introduction, local transmission, ongoing evolution, and spread of SARS-CoV-2 during the first four infection waves using 353 high-quality near-whole genomes sampled in Ethiopia. Our results show that whereas viral introductions seeded the first wave, subsequent waves were seeded by local transmission. The B.1.480 lineage emerged in the first wave and notably remained in circulation even after the emergence of the Alpha variant. The B.1.480 was outcompeted by the Delta variant. Notably, Ethiopia’s lack of local sequencing capacity was further limited by sporadic, uneven, and insufficient sampling that limited the incorporation of genomic epidemiology in the epidemic public health response in Ethiopia. These results highlight Ethiopia’s role in SARS-CoV-2 dissemination and the urgent need for balanced, near-real-time genomic sequencing. 2023-03-13 2023-03-21T09:55:33Z 2023-03-21T09:55:33Z Journal Article https://hdl.handle.net/10568/129697 en Open Access MDPI Sisay, A., Tshiabuila, D., Wyk, S. van, Tesfaye, A., Mboowa, G., Oyola, S.O., Tesema, S.K., Baxter, C., Martin, D., Lessells, R., Tegally, H., Moir, M., Giandhari, J., Pillay, S., Singh, L., Ramphal, Y., Maharaj, A., Pillay, Y., Maharaj, A., Naidoo, Y., Ramphal, U., Chabuka, L., Wilkinson, E., Oliveira, T. de, Desta, A.F. and San, J.E. 2023. Molecular epidemiology and diversity of SARS-CoV-2 in Ethiopia, 2020–2022. Genes 14(3): 705. |
| spellingShingle | covid-19 health epidemiology Sisay, A. Tshiabuila, D. Wyk, S. van Tesfaye, A. Mboowa, G. Oyola, Samuel O. Tesema, S.K. Baxter, C. Martin, D. Lessells, R. Tegally, H. Moir, M. Giandhari, J. Pillay, S. Singh, L. Ramphal, Y. Maharaj, A. Pillay, Y. Naidoo, Y. Ramphal, U. Chabuka, L. Wilkinson, E. Oliveira, T. de Desta, A.F. San, J.E. Molecular epidemiology and diversity of SARS-CoV-2 in Ethiopia, 2020–2022 |
| title | Molecular epidemiology and diversity of SARS-CoV-2 in Ethiopia, 2020–2022 |
| title_full | Molecular epidemiology and diversity of SARS-CoV-2 in Ethiopia, 2020–2022 |
| title_fullStr | Molecular epidemiology and diversity of SARS-CoV-2 in Ethiopia, 2020–2022 |
| title_full_unstemmed | Molecular epidemiology and diversity of SARS-CoV-2 in Ethiopia, 2020–2022 |
| title_short | Molecular epidemiology and diversity of SARS-CoV-2 in Ethiopia, 2020–2022 |
| title_sort | molecular epidemiology and diversity of sars cov 2 in ethiopia 2020 2022 |
| topic | covid-19 health epidemiology |
| url | https://hdl.handle.net/10568/129697 |
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