MIB–MIP is a mycoplasma system that captures and cleaves immunoglobulin G
Mycoplasmas are minimal pathogenic bacteria able to infect humans and a wide range of economically important animals; as such, they are major causes of concern in the medical and veterinary fields. These pathogens often lead to chronic infections, and their mechanisms of immunity evasion are poorly...
| Main Authors: | , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
National Academy of Sciences
2016
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/129486 |
| _version_ | 1855534944459161600 |
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| author | Arfi, Yonathan Minder, Laetitia Primo, Carmelo di Le Roy, Aline Ebel, Christine Coquet, Laurent Claverol, Stephane Vashee, Sanjay Jores, Joerg Blanchard, Alain Sirand-Pugnet, Pascal |
| author_browse | Arfi, Yonathan Blanchard, Alain Claverol, Stephane Coquet, Laurent Ebel, Christine Jores, Joerg Le Roy, Aline Minder, Laetitia Primo, Carmelo di Sirand-Pugnet, Pascal Vashee, Sanjay |
| author_facet | Arfi, Yonathan Minder, Laetitia Primo, Carmelo di Le Roy, Aline Ebel, Christine Coquet, Laurent Claverol, Stephane Vashee, Sanjay Jores, Joerg Blanchard, Alain Sirand-Pugnet, Pascal |
| author_sort | Arfi, Yonathan |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Mycoplasmas are minimal pathogenic bacteria able to infect humans and a wide range of economically important animals; as such, they are major causes of concern in the medical and veterinary fields. These pathogens often lead to chronic infections, and their mechanisms of immunity evasion are poorly known. Here we describe a two-protein system from the ruminant pathogenMycoplasma mycoidessubspeciescaprithat is involved in the capture and cleavage of antibodies. MIB is able to capture the antibodies and to subsequently recruit MIP, a protease that is able to cleave the antibody heavy chain. The MIB–MIP system appears to be widespread among pathogenic mycoplasmas and is potentially a key player for the virulence and immunity evasion mechanisms of these bacteria. |
| format | Journal Article |
| id | CGSpace129486 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | National Academy of Sciences |
| publisherStr | National Academy of Sciences |
| record_format | dspace |
| spelling | CGSpace1294862025-12-08T09:54:28Z MIB–MIP is a mycoplasma system that captures and cleaves immunoglobulin G Arfi, Yonathan Minder, Laetitia Primo, Carmelo di Le Roy, Aline Ebel, Christine Coquet, Laurent Claverol, Stephane Vashee, Sanjay Jores, Joerg Blanchard, Alain Sirand-Pugnet, Pascal mycoplasma system Mycoplasmas are minimal pathogenic bacteria able to infect humans and a wide range of economically important animals; as such, they are major causes of concern in the medical and veterinary fields. These pathogens often lead to chronic infections, and their mechanisms of immunity evasion are poorly known. Here we describe a two-protein system from the ruminant pathogenMycoplasma mycoidessubspeciescaprithat is involved in the capture and cleavage of antibodies. MIB is able to capture the antibodies and to subsequently recruit MIP, a protease that is able to cleave the antibody heavy chain. The MIB–MIP system appears to be widespread among pathogenic mycoplasmas and is potentially a key player for the virulence and immunity evasion mechanisms of these bacteria. 2016-05-10 2023-03-10T14:36:35Z 2023-03-10T14:36:35Z Journal Article https://hdl.handle.net/10568/129486 en Open Access National Academy of Sciences Arfi, Yonathan; Minder, Laetitia; Primo, Carmelo di; Le Roy, Aline; Ebel, Christine; Coquet, Laurent; Claverol, Stephane; Vashee, Sanjay; Jores, Joerg; Blanchard, Alain; Sirand-Pugnet, Pascal. 2016. MIB-MIP is a mycoplasma system that captures and cleaves immunoglobulin G. Proceedings of the National Academy of Sciences 113: 5406-5411 |
| spellingShingle | mycoplasma system Arfi, Yonathan Minder, Laetitia Primo, Carmelo di Le Roy, Aline Ebel, Christine Coquet, Laurent Claverol, Stephane Vashee, Sanjay Jores, Joerg Blanchard, Alain Sirand-Pugnet, Pascal MIB–MIP is a mycoplasma system that captures and cleaves immunoglobulin G |
| title | MIB–MIP is a mycoplasma system that captures and cleaves immunoglobulin G |
| title_full | MIB–MIP is a mycoplasma system that captures and cleaves immunoglobulin G |
| title_fullStr | MIB–MIP is a mycoplasma system that captures and cleaves immunoglobulin G |
| title_full_unstemmed | MIB–MIP is a mycoplasma system that captures and cleaves immunoglobulin G |
| title_short | MIB–MIP is a mycoplasma system that captures and cleaves immunoglobulin G |
| title_sort | mib mip is a mycoplasma system that captures and cleaves immunoglobulin g |
| topic | mycoplasma system |
| url | https://hdl.handle.net/10568/129486 |
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