Analyses of Twelve New Whole Genome Sequences of Cassava Brown Streak Viruses and Ugandan Cassava Brown Streak Viruses from East Africa: Diversity, Supercomputing and Evidence for Further Speciation
Cassava brown streak disease is caused by two devastating viruses, Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV) which are frequently found infecting cassava, one of sub-Saharan Africa’s most important staple food crops. Each year these viruses cause losses of up t...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Public Library of Science
2015
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/129485 |
| _version_ | 1855525120261488640 |
|---|---|
| author | Ndunguru, Joseph Sseruwagi, Peter Tairo, Fred Stomeo, Francesca Maina, Solomon Djikeng, Appolinaire Kehoe, Monica Boykin, Laura M. |
| author_browse | Boykin, Laura M. Djikeng, Appolinaire Kehoe, Monica Maina, Solomon Ndunguru, Joseph Sseruwagi, Peter Stomeo, Francesca Tairo, Fred |
| author_facet | Ndunguru, Joseph Sseruwagi, Peter Tairo, Fred Stomeo, Francesca Maina, Solomon Djikeng, Appolinaire Kehoe, Monica Boykin, Laura M. |
| author_sort | Ndunguru, Joseph |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Cassava brown streak disease is caused by two devastating viruses, Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV) which are frequently found infecting cassava, one of sub-Saharan Africa’s most important staple food crops. Each year these viruses cause losses of up to $100 million USD and can leave entire families without their primary food source, for an entire year. Twelve new whole genomes, including seven of CBSV and five of UCBSV were uncovered in this research, doubling the genomic sequences available in the public domain for these viruses. These new sequences disprove the assumption that the viruses are limited by agro-ecological zones, show that current diagnostic primers are insufficient to provide confident diagnosis of these viruses and give rise to the possibility that there may be as many as four distinct species of virus. Utilizing NGS sequencing technologies and proper phylogenetic practices will rapidly increase the solution to sustainable cassava production. |
| format | Journal Article |
| id | CGSpace129485 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2015 |
| publishDateRange | 2015 |
| publishDateSort | 2015 |
| publisher | Public Library of Science |
| publisherStr | Public Library of Science |
| record_format | dspace |
| spelling | CGSpace1294852024-08-27T10:35:58Z Analyses of Twelve New Whole Genome Sequences of Cassava Brown Streak Viruses and Ugandan Cassava Brown Streak Viruses from East Africa: Diversity, Supercomputing and Evidence for Further Speciation Ndunguru, Joseph Sseruwagi, Peter Tairo, Fred Stomeo, Francesca Maina, Solomon Djikeng, Appolinaire Kehoe, Monica Boykin, Laura M. cassava viruses africa east africa Cassava brown streak disease is caused by two devastating viruses, Cassava brown streak virus (CBSV) and Ugandan cassava brown streak virus (UCBSV) which are frequently found infecting cassava, one of sub-Saharan Africa’s most important staple food crops. Each year these viruses cause losses of up to $100 million USD and can leave entire families without their primary food source, for an entire year. Twelve new whole genomes, including seven of CBSV and five of UCBSV were uncovered in this research, doubling the genomic sequences available in the public domain for these viruses. These new sequences disprove the assumption that the viruses are limited by agro-ecological zones, show that current diagnostic primers are insufficient to provide confident diagnosis of these viruses and give rise to the possibility that there may be as many as four distinct species of virus. Utilizing NGS sequencing technologies and proper phylogenetic practices will rapidly increase the solution to sustainable cassava production. 2015-10-06 2023-03-10T14:36:33Z 2023-03-10T14:36:33Z Journal Article https://hdl.handle.net/10568/129485 en Open Access Public Library of Science Ndunguru, Joseph; Sseruwagi, Peter; Tairo, Fred; Stomeo, Francesca; Maina, Solomon; Djikeng, Appolinaire; Kehoe, Monica; Boykin, Laura M. 2015. Analyses of Twelve New Whole Genome Sequences of Cassava Brown Streak Viruses and Ugandan Cassava Brown Streak Viruses from East Africa: Diversity, Supercomputing and Evidence for Further Speciation. PLOS ONE 10: e0139321 |
| spellingShingle | cassava viruses africa east africa Ndunguru, Joseph Sseruwagi, Peter Tairo, Fred Stomeo, Francesca Maina, Solomon Djikeng, Appolinaire Kehoe, Monica Boykin, Laura M. Analyses of Twelve New Whole Genome Sequences of Cassava Brown Streak Viruses and Ugandan Cassava Brown Streak Viruses from East Africa: Diversity, Supercomputing and Evidence for Further Speciation |
| title | Analyses of Twelve New Whole Genome Sequences of Cassava Brown Streak Viruses and Ugandan Cassava Brown Streak Viruses from East Africa: Diversity, Supercomputing and Evidence for Further Speciation |
| title_full | Analyses of Twelve New Whole Genome Sequences of Cassava Brown Streak Viruses and Ugandan Cassava Brown Streak Viruses from East Africa: Diversity, Supercomputing and Evidence for Further Speciation |
| title_fullStr | Analyses of Twelve New Whole Genome Sequences of Cassava Brown Streak Viruses and Ugandan Cassava Brown Streak Viruses from East Africa: Diversity, Supercomputing and Evidence for Further Speciation |
| title_full_unstemmed | Analyses of Twelve New Whole Genome Sequences of Cassava Brown Streak Viruses and Ugandan Cassava Brown Streak Viruses from East Africa: Diversity, Supercomputing and Evidence for Further Speciation |
| title_short | Analyses of Twelve New Whole Genome Sequences of Cassava Brown Streak Viruses and Ugandan Cassava Brown Streak Viruses from East Africa: Diversity, Supercomputing and Evidence for Further Speciation |
| title_sort | analyses of twelve new whole genome sequences of cassava brown streak viruses and ugandan cassava brown streak viruses from east africa diversity supercomputing and evidence for further speciation |
| topic | cassava viruses africa east africa |
| url | https://hdl.handle.net/10568/129485 |
| work_keys_str_mv | AT ndungurujoseph analysesoftwelvenewwholegenomesequencesofcassavabrownstreakvirusesandugandancassavabrownstreakvirusesfromeastafricadiversitysupercomputingandevidenceforfurtherspeciation AT sseruwagipeter analysesoftwelvenewwholegenomesequencesofcassavabrownstreakvirusesandugandancassavabrownstreakvirusesfromeastafricadiversitysupercomputingandevidenceforfurtherspeciation AT tairofred analysesoftwelvenewwholegenomesequencesofcassavabrownstreakvirusesandugandancassavabrownstreakvirusesfromeastafricadiversitysupercomputingandevidenceforfurtherspeciation AT stomeofrancesca analysesoftwelvenewwholegenomesequencesofcassavabrownstreakvirusesandugandancassavabrownstreakvirusesfromeastafricadiversitysupercomputingandevidenceforfurtherspeciation AT mainasolomon analysesoftwelvenewwholegenomesequencesofcassavabrownstreakvirusesandugandancassavabrownstreakvirusesfromeastafricadiversitysupercomputingandevidenceforfurtherspeciation AT djikengappolinaire analysesoftwelvenewwholegenomesequencesofcassavabrownstreakvirusesandugandancassavabrownstreakvirusesfromeastafricadiversitysupercomputingandevidenceforfurtherspeciation AT kehoemonica analysesoftwelvenewwholegenomesequencesofcassavabrownstreakvirusesandugandancassavabrownstreakvirusesfromeastafricadiversitysupercomputingandevidenceforfurtherspeciation AT boykinlauram analysesoftwelvenewwholegenomesequencesofcassavabrownstreakvirusesandugandancassavabrownstreakvirusesfromeastafricadiversitysupercomputingandevidenceforfurtherspeciation |