Characterization of Anamnestic T-cell Responses Induced by Conventional Vaccines against Contagious Bovine Pleuropneumonia
A better understanding of how T1 vaccination confers immunity would facilitate the rational design of improved vaccines against contagious bovine pleuropneumonia (CBPP). We show here that mycoplasmas-induced recall proliferation and IFN-γ responses are detected in cattle that received multiple shots...
| Autores principales: | , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Public Library of Science
2013
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/129413 |
| _version_ | 1855541970112348160 |
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| author | Totte, Philippe Yaya, Aboubakar Sery, Amadou Wesonga, Hezron Wade, Abel Naessens, Jan Niang, Mamadou Thiaucourt, François |
| author_browse | Naessens, Jan Niang, Mamadou Sery, Amadou Thiaucourt, François Totte, Philippe Wade, Abel Wesonga, Hezron Yaya, Aboubakar |
| author_facet | Totte, Philippe Yaya, Aboubakar Sery, Amadou Wesonga, Hezron Wade, Abel Naessens, Jan Niang, Mamadou Thiaucourt, François |
| author_sort | Totte, Philippe |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | A better understanding of how T1 vaccination confers immunity would facilitate the rational design of improved vaccines against contagious bovine pleuropneumonia (CBPP). We show here that mycoplasmas-induced recall proliferation and IFN-γ responses are detected in cattle that received multiple shots of T1 vaccines. These anamnestic responses were under the strict control of CD4+ T lymphocytes. Moreover, CD62L expression indicated that both CD4+ effector memory (Tem) and central memory (Tcm) T lymphocytes are elicited in these animals. Comparative analysis with data from cattle that completely recovered from CBPP infection revealed similar anamnestic T-cell responses albeit at a lower magnitude for T1-vaccinated animals, particularly in the Tcm compartment. In conclusion, we discuss how our current understanding of T-cell responses will contribute to ongoing efforts for the improvement of future CBPP vaccines. |
| format | Journal Article |
| id | CGSpace129413 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
| publisher | Public Library of Science |
| publisherStr | Public Library of Science |
| record_format | dspace |
| spelling | CGSpace1294132025-01-24T14:20:57Z Characterization of Anamnestic T-cell Responses Induced by Conventional Vaccines against Contagious Bovine Pleuropneumonia Totte, Philippe Yaya, Aboubakar Sery, Amadou Wesonga, Hezron Wade, Abel Naessens, Jan Niang, Mamadou Thiaucourt, François vaccines contagious bovine pleuropneumonia bovine pleuropneumonia A better understanding of how T1 vaccination confers immunity would facilitate the rational design of improved vaccines against contagious bovine pleuropneumonia (CBPP). We show here that mycoplasmas-induced recall proliferation and IFN-γ responses are detected in cattle that received multiple shots of T1 vaccines. These anamnestic responses were under the strict control of CD4+ T lymphocytes. Moreover, CD62L expression indicated that both CD4+ effector memory (Tem) and central memory (Tcm) T lymphocytes are elicited in these animals. Comparative analysis with data from cattle that completely recovered from CBPP infection revealed similar anamnestic T-cell responses albeit at a lower magnitude for T1-vaccinated animals, particularly in the Tcm compartment. In conclusion, we discuss how our current understanding of T-cell responses will contribute to ongoing efforts for the improvement of future CBPP vaccines. 2013-02-28 2023-03-10T14:34:44Z 2023-03-10T14:34:44Z Journal Article https://hdl.handle.net/10568/129413 en Open Access Public Library of Science Totte, Philippe; Yaya, Aboubakar; Sery, Amadou; Wesonga, Hezron; Wade, Abel; Naessens, Jan; Niang, Mamadou; Thiaucourt, François. 2013. Characterization of Anamnestic T-cell Responses Induced by Conventional Vaccines against Contagious Bovine Pleuropneumonia. PLoS ONE 8: e57509 |
| spellingShingle | vaccines contagious bovine pleuropneumonia bovine pleuropneumonia Totte, Philippe Yaya, Aboubakar Sery, Amadou Wesonga, Hezron Wade, Abel Naessens, Jan Niang, Mamadou Thiaucourt, François Characterization of Anamnestic T-cell Responses Induced by Conventional Vaccines against Contagious Bovine Pleuropneumonia |
| title | Characterization of Anamnestic T-cell Responses Induced by Conventional Vaccines against Contagious Bovine Pleuropneumonia |
| title_full | Characterization of Anamnestic T-cell Responses Induced by Conventional Vaccines against Contagious Bovine Pleuropneumonia |
| title_fullStr | Characterization of Anamnestic T-cell Responses Induced by Conventional Vaccines against Contagious Bovine Pleuropneumonia |
| title_full_unstemmed | Characterization of Anamnestic T-cell Responses Induced by Conventional Vaccines against Contagious Bovine Pleuropneumonia |
| title_short | Characterization of Anamnestic T-cell Responses Induced by Conventional Vaccines against Contagious Bovine Pleuropneumonia |
| title_sort | characterization of anamnestic t cell responses induced by conventional vaccines against contagious bovine pleuropneumonia |
| topic | vaccines contagious bovine pleuropneumonia bovine pleuropneumonia |
| url | https://hdl.handle.net/10568/129413 |
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