Secreted Trypanosome Cyclophilin Inactivates Lytic Insect Defense Peptides and Induces Parasite Calcineurin Activation and Infectivity

The mechanisms by which <i>Trypanosoma cruzi</i> survives antimicrobial peptides and differentiates during its transit through the gastrointestinal tract of the reduviid vector are unknown. We show that cyclophilin, a peptidyl-prolyl isomerase secreted from <i>T. cruzi</i> epimastigotes, binds to an...

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Bibliographic Details
Main Authors: Kulkarni, Manjusha M., Karafova, Anna, Kamysz, Wojciech, Schenkman, Sergio, Pellé, Roger, McGwire, Bradford S.
Format: Journal Article
Language:Inglés
Published: Elsevier 2013
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Online Access:https://hdl.handle.net/10568/129407

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