Giraffe genome sequence reveals clues to its unique morphology and physiology
The origins of giraffe's imposing stature and associated cardiovascular adaptations are unknown. Okapi, which lacks these unique features, is giraffe's closest relative and provides a useful comparison, to identify genetic variation underlying giraffe's long neck and cardiovascular system. The genom...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Springer
2016
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/129392 |
| _version_ | 1855537157499781120 |
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| author | Agaba, Morris Ishengoma, Edson Miller, Webb C. McGrath, Barbara C. Hudson, Chelsea N. Bedoya Reina, Oscar C. Ratan, Aakrosh Burhans, Rico Chikhi, Rayan Medvedev, Paul Praul, Craig A. Wu-Cavener, Lan Wood, Brendan Robertson, Heather Penfold, Linda Cavener, Douglas R. |
| author_browse | Agaba, Morris Bedoya Reina, Oscar C. Burhans, Rico Cavener, Douglas R. Chikhi, Rayan Hudson, Chelsea N. Ishengoma, Edson McGrath, Barbara C. Medvedev, Paul Miller, Webb C. Penfold, Linda Praul, Craig A. Ratan, Aakrosh Robertson, Heather Wood, Brendan Wu-Cavener, Lan |
| author_facet | Agaba, Morris Ishengoma, Edson Miller, Webb C. McGrath, Barbara C. Hudson, Chelsea N. Bedoya Reina, Oscar C. Ratan, Aakrosh Burhans, Rico Chikhi, Rayan Medvedev, Paul Praul, Craig A. Wu-Cavener, Lan Wood, Brendan Robertson, Heather Penfold, Linda Cavener, Douglas R. |
| author_sort | Agaba, Morris |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | The origins of giraffe's imposing stature and associated cardiovascular adaptations are unknown. Okapi, which lacks these unique features, is giraffe's closest relative and provides a useful comparison, to identify genetic variation underlying giraffe's long neck and cardiovascular system. The genomes of giraffe and okapi were sequenced, and through comparative analyses genes and pathways were identified that exhibit unique genetic changes and likely contribute to giraffe's unique features. Some of these genes are in the HOX, NOTCH and FGF signalling pathways, which regulate both skeletal and cardiovascular development, suggesting that giraffe's stature and cardiovascular adaptations evolved in parallel through changes in a small number of genes. Mitochondrial metabolism and volatile fatty acids transport genes are also evolutionarily diverged in giraffe and may be related to its unusual diet that includes toxic plants. Unexpectedly, substantial evolutionary changes have occurred in giraffe and okapi in double-strand break repair and centrosome functions. |
| format | Journal Article |
| id | CGSpace129392 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2016 |
| publishDateRange | 2016 |
| publishDateSort | 2016 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace1293922024-10-03T07:40:58Z Giraffe genome sequence reveals clues to its unique morphology and physiology Agaba, Morris Ishengoma, Edson Miller, Webb C. McGrath, Barbara C. Hudson, Chelsea N. Bedoya Reina, Oscar C. Ratan, Aakrosh Burhans, Rico Chikhi, Rayan Medvedev, Paul Praul, Craig A. Wu-Cavener, Lan Wood, Brendan Robertson, Heather Penfold, Linda Cavener, Douglas R. physiology morphology The origins of giraffe's imposing stature and associated cardiovascular adaptations are unknown. Okapi, which lacks these unique features, is giraffe's closest relative and provides a useful comparison, to identify genetic variation underlying giraffe's long neck and cardiovascular system. The genomes of giraffe and okapi were sequenced, and through comparative analyses genes and pathways were identified that exhibit unique genetic changes and likely contribute to giraffe's unique features. Some of these genes are in the HOX, NOTCH and FGF signalling pathways, which regulate both skeletal and cardiovascular development, suggesting that giraffe's stature and cardiovascular adaptations evolved in parallel through changes in a small number of genes. Mitochondrial metabolism and volatile fatty acids transport genes are also evolutionarily diverged in giraffe and may be related to its unusual diet that includes toxic plants. Unexpectedly, substantial evolutionary changes have occurred in giraffe and okapi in double-strand break repair and centrosome functions. 2016-05-17 2023-03-10T14:34:19Z 2023-03-10T14:34:19Z Journal Article https://hdl.handle.net/10568/129392 en Open Access Springer Agaba, Morris; Ishengoma, Edson; Miller, Webb C.; McGrath, Barbara C.; Hudson, Chelsea N.; Bedoya Reina, Oscar C.; Ratan, Aakrosh; Burhans, Rico; Chikhi, Rayan; Medvedev, Paul; Praul, Craig A.; Wu-Cavener, Lan; Wood, Brendan; Robertson, Heather; Penfold, Linda; Cavener, Douglas R. 2016. Giraffe genome sequence reveals clues to its unique morphology and physiology. Nature Communications 7: |
| spellingShingle | physiology morphology Agaba, Morris Ishengoma, Edson Miller, Webb C. McGrath, Barbara C. Hudson, Chelsea N. Bedoya Reina, Oscar C. Ratan, Aakrosh Burhans, Rico Chikhi, Rayan Medvedev, Paul Praul, Craig A. Wu-Cavener, Lan Wood, Brendan Robertson, Heather Penfold, Linda Cavener, Douglas R. Giraffe genome sequence reveals clues to its unique morphology and physiology |
| title | Giraffe genome sequence reveals clues to its unique morphology and physiology |
| title_full | Giraffe genome sequence reveals clues to its unique morphology and physiology |
| title_fullStr | Giraffe genome sequence reveals clues to its unique morphology and physiology |
| title_full_unstemmed | Giraffe genome sequence reveals clues to its unique morphology and physiology |
| title_short | Giraffe genome sequence reveals clues to its unique morphology and physiology |
| title_sort | giraffe genome sequence reveals clues to its unique morphology and physiology |
| topic | physiology morphology |
| url | https://hdl.handle.net/10568/129392 |
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