Evaluation of Pneumococcal Load in Blood by Polymerase Chain Reaction for the Diagnosis of Pneumococcal Pneumonia in Young Children in the PERCH Study
Detection of pneumococcus by lytA polymerase chain reaction (PCR) in blood had poor diagnostic accuracy for diagnosing pneumococcal pneumonia in children in 9 African and Asian sites. We assessed the value of blood lytA quantification in diagnosing pneumococcal pneumonia. The Pneumonia Etiology Rese...
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Oxford University Press
2017
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/129300 |
| _version_ | 1855521314281881600 |
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| author | Deloria Knoll, Maria Morpeth, Susan C. Scott, J.Anthony G. Watson, Nora L. Park, Daniel E. Baggett, Henry C. Brooks, W. Abdullah Feikin, Daniel R. Hammitt, Laura L. Howie, Stephen R.C. Kotloff, Karen L. Levine, Orin S. O’Brien, Katherine L. Thea, Donald M. Ahmed, Dilruba Antonio, Martin Awori, Juliet O. Baillie, Vicky L. Chipeta, James Deluca, Andrea N. Dione, Michel M. Driscoll, Amanda J. Higdon, Melissa M. Jatapai, Anchalee Karron, Ruth A. Mazumder, Razib Moore, David P. Mwansa, James Nyongesa, Sammy Prosperi, Christine Seidenberg, Phil Siludjai, Duangkamon Sow, Samba O. Tamboura, Boubou Zeger, Scott L. Murdoch, David R. Madhi, Shabir A. Knoll, Maria Deloria Fancourt, Nicholas Fu, Wei Kagucia, E.Wangeci Li, Mengying Wu, Zhenke Crawley, Jane Endtz, Hubert P. Zaman, Khalequ Goswami, Doli Hossain, Lokman Jahan, Yasmin Ashraf, Hasan Ebruke, Bernard E. McLellan, Jessica Machuka, Eunice M. Shamsul, Arifin Zaman, Syed M.A. Mackenzie, Grant Kamau, Alice Kazungu, Sidi Ominde, Micah Silaba Tapia, Milagritos D. Sylla, Mamadou Onwuchekwa, Uma Kourouma, Nana Touré, Aliou Adrian, Peter V. Kuwanda, Locadiah Mudau, Azwifarwi Groome, Michelle J. Mahomed, Nasreen Thamthitiwat, Somsak Maloney, Susan A. Bunthi, Charatdao Rhodes, Julia Sawatwong, Pongpun Akarasewi, Pasakorn Mwananyanda, Lawrence Wa Somwe, Somwe Kwenda, Geoffrey Anderson, Trevor P. Mitchell, Joanne |
| author_browse | Adrian, Peter V. Ahmed, Dilruba Akarasewi, Pasakorn Anderson, Trevor P. Antonio, Martin Ashraf, Hasan Awori, Juliet O. Baggett, Henry C. Baillie, Vicky L. Brooks, W. Abdullah Bunthi, Charatdao Chipeta, James Crawley, Jane Deloria Knoll, Maria Deluca, Andrea N. Dione, Michel M. Driscoll, Amanda J. Ebruke, Bernard E. Endtz, Hubert P. Fancourt, Nicholas Feikin, Daniel R. Fu, Wei Goswami, Doli Groome, Michelle J. Hammitt, Laura L. Higdon, Melissa M. Hossain, Lokman Howie, Stephen R.C. Jahan, Yasmin Jatapai, Anchalee Kagucia, E.Wangeci Kamau, Alice Karron, Ruth A. Kazungu, Sidi Knoll, Maria Deloria Kotloff, Karen L. Kourouma, Nana Kuwanda, Locadiah Kwenda, Geoffrey Levine, Orin S. Li, Mengying Machuka, Eunice M. Mackenzie, Grant Madhi, Shabir A. Mahomed, Nasreen Maloney, Susan A. Mazumder, Razib McLellan, Jessica Mitchell, Joanne Moore, David P. Morpeth, Susan C. Mudau, Azwifarwi Murdoch, David R. Mwananyanda, Lawrence Mwansa, James Nyongesa, Sammy Ominde, Micah Silaba Onwuchekwa, Uma O’Brien, Katherine L. Park, Daniel E. Prosperi, Christine Rhodes, Julia Sawatwong, Pongpun Scott, J.Anthony G. Seidenberg, Phil Shamsul, Arifin Siludjai, Duangkamon Sow, Samba O. Sylla, Mamadou Tamboura, Boubou Tapia, Milagritos D. Thamthitiwat, Somsak Thea, Donald M. Touré, Aliou Wa Somwe, Somwe Watson, Nora L. Wu, Zhenke Zaman, Khalequ Zaman, Syed M.A. Zeger, Scott L. |
| author_facet | Deloria Knoll, Maria Morpeth, Susan C. Scott, J.Anthony G. Watson, Nora L. Park, Daniel E. Baggett, Henry C. Brooks, W. Abdullah Feikin, Daniel R. Hammitt, Laura L. Howie, Stephen R.C. Kotloff, Karen L. Levine, Orin S. O’Brien, Katherine L. Thea, Donald M. Ahmed, Dilruba Antonio, Martin Awori, Juliet O. Baillie, Vicky L. Chipeta, James Deluca, Andrea N. Dione, Michel M. Driscoll, Amanda J. Higdon, Melissa M. Jatapai, Anchalee Karron, Ruth A. Mazumder, Razib Moore, David P. Mwansa, James Nyongesa, Sammy Prosperi, Christine Seidenberg, Phil Siludjai, Duangkamon Sow, Samba O. Tamboura, Boubou Zeger, Scott L. Murdoch, David R. Madhi, Shabir A. Knoll, Maria Deloria Fancourt, Nicholas Fu, Wei Kagucia, E.Wangeci Li, Mengying Wu, Zhenke Crawley, Jane Endtz, Hubert P. Zaman, Khalequ Goswami, Doli Hossain, Lokman Jahan, Yasmin Ashraf, Hasan Ebruke, Bernard E. McLellan, Jessica Machuka, Eunice M. Shamsul, Arifin Zaman, Syed M.A. Mackenzie, Grant Kamau, Alice Kazungu, Sidi Ominde, Micah Silaba Tapia, Milagritos D. Sylla, Mamadou Onwuchekwa, Uma Kourouma, Nana Touré, Aliou Adrian, Peter V. Kuwanda, Locadiah Mudau, Azwifarwi Groome, Michelle J. Mahomed, Nasreen Thamthitiwat, Somsak Maloney, Susan A. Bunthi, Charatdao Rhodes, Julia Sawatwong, Pongpun Akarasewi, Pasakorn Mwananyanda, Lawrence Wa Somwe, Somwe Kwenda, Geoffrey Anderson, Trevor P. Mitchell, Joanne |
| author_sort | Deloria Knoll, Maria |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Detection of pneumococcus by lytA polymerase chain reaction (PCR) in blood had poor diagnostic accuracy for diagnosing pneumococcal pneumonia in children in 9 African and Asian sites. We assessed the value of blood lytA quantification in diagnosing pneumococcal pneumonia. The Pneumonia Etiology Research for Child Health (PERCH) case-control study tested whole blood by PCR for pneumococcus in children aged 1–59 months hospitalized with signs of pneumonia and in age–frequency matched community controls. The distribution of load among PCR-positive participants was compared between microbiologically confirmed pneumococcal pneumonia (MCPP) cases, cases confirmed for nonpneumococcal pathogens, nonconfirmed cases, and controls. Receiver operating characteristic analyses determined the "optimal threshold" that distinguished MCPP cases from controls. Load was available for 290 of 291 cases with pneumococcal PCR detected in blood and 273 of 273 controls. Load was higher in MCPP cases than controls (median, 4.0 × 103 vs 0.19 × 103 copies/mL), but overlapped substantially (range, 0.16–989.9 × 103 copies/mL and 0.01–551.9 × 103 copies/mL, respectively). The proportion with high load (≥2.2 log10 copies/mL) was 62.5% among MCPP cases, 4.3% among nonconfirmed cases, 9.3% among cases confirmed for a nonpneumococcal pathogen, and 3.1% among controls. Pneumococcal load in blood was not associated with respiratory tract illness in controls (P = .32). High blood pneumococcal load was associated with alveolar consolidation on chest radiograph in nonconfirmed cases, and with high (>6.9 log10 copies/mL) nasopharyngeal/oropharyngeal load and C-reactive protein ≥40 mg/L (both P < .01) in nonconfirmed cases but not controls. Quantitative pneumococcal PCR in blood has limited diagnostic utility for identifying pneumococcal pneumonia in individual children, but may be informative in epidemiological studies. |
| format | Journal Article |
| id | CGSpace129300 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2017 |
| publishDateRange | 2017 |
| publishDateSort | 2017 |
| publisher | Oxford University Press |
| publisherStr | Oxford University Press |
| record_format | dspace |
| spelling | CGSpace1293002025-12-08T09:54:28Z Evaluation of Pneumococcal Load in Blood by Polymerase Chain Reaction for the Diagnosis of Pneumococcal Pneumonia in Young Children in the PERCH Study Deloria Knoll, Maria Morpeth, Susan C. Scott, J.Anthony G. Watson, Nora L. Park, Daniel E. Baggett, Henry C. Brooks, W. Abdullah Feikin, Daniel R. Hammitt, Laura L. Howie, Stephen R.C. Kotloff, Karen L. Levine, Orin S. O’Brien, Katherine L. Thea, Donald M. Ahmed, Dilruba Antonio, Martin Awori, Juliet O. Baillie, Vicky L. Chipeta, James Deluca, Andrea N. Dione, Michel M. Driscoll, Amanda J. Higdon, Melissa M. Jatapai, Anchalee Karron, Ruth A. Mazumder, Razib Moore, David P. Mwansa, James Nyongesa, Sammy Prosperi, Christine Seidenberg, Phil Siludjai, Duangkamon Sow, Samba O. Tamboura, Boubou Zeger, Scott L. Murdoch, David R. Madhi, Shabir A. Knoll, Maria Deloria Fancourt, Nicholas Fu, Wei Kagucia, E.Wangeci Li, Mengying Wu, Zhenke Crawley, Jane Endtz, Hubert P. Zaman, Khalequ Goswami, Doli Hossain, Lokman Jahan, Yasmin Ashraf, Hasan Ebruke, Bernard E. McLellan, Jessica Machuka, Eunice M. Shamsul, Arifin Zaman, Syed M.A. Mackenzie, Grant Kamau, Alice Kazungu, Sidi Ominde, Micah Silaba Tapia, Milagritos D. Sylla, Mamadou Onwuchekwa, Uma Kourouma, Nana Touré, Aliou Adrian, Peter V. Kuwanda, Locadiah Mudau, Azwifarwi Groome, Michelle J. Mahomed, Nasreen Thamthitiwat, Somsak Maloney, Susan A. Bunthi, Charatdao Rhodes, Julia Sawatwong, Pongpun Akarasewi, Pasakorn Mwananyanda, Lawrence Wa Somwe, Somwe Kwenda, Geoffrey Anderson, Trevor P. Mitchell, Joanne evaluation diagnosis children blood polymerase chain reaction pneumonia Detection of pneumococcus by lytA polymerase chain reaction (PCR) in blood had poor diagnostic accuracy for diagnosing pneumococcal pneumonia in children in 9 African and Asian sites. We assessed the value of blood lytA quantification in diagnosing pneumococcal pneumonia. The Pneumonia Etiology Research for Child Health (PERCH) case-control study tested whole blood by PCR for pneumococcus in children aged 1–59 months hospitalized with signs of pneumonia and in age–frequency matched community controls. The distribution of load among PCR-positive participants was compared between microbiologically confirmed pneumococcal pneumonia (MCPP) cases, cases confirmed for nonpneumococcal pathogens, nonconfirmed cases, and controls. Receiver operating characteristic analyses determined the "optimal threshold" that distinguished MCPP cases from controls. Load was available for 290 of 291 cases with pneumococcal PCR detected in blood and 273 of 273 controls. Load was higher in MCPP cases than controls (median, 4.0 × 103 vs 0.19 × 103 copies/mL), but overlapped substantially (range, 0.16–989.9 × 103 copies/mL and 0.01–551.9 × 103 copies/mL, respectively). The proportion with high load (≥2.2 log10 copies/mL) was 62.5% among MCPP cases, 4.3% among nonconfirmed cases, 9.3% among cases confirmed for a nonpneumococcal pathogen, and 3.1% among controls. Pneumococcal load in blood was not associated with respiratory tract illness in controls (P = .32). High blood pneumococcal load was associated with alveolar consolidation on chest radiograph in nonconfirmed cases, and with high (>6.9 log10 copies/mL) nasopharyngeal/oropharyngeal load and C-reactive protein ≥40 mg/L (both P < .01) in nonconfirmed cases but not controls. Quantitative pneumococcal PCR in blood has limited diagnostic utility for identifying pneumococcal pneumonia in individual children, but may be informative in epidemiological studies. 2017-06-15 2023-03-10T14:33:04Z 2023-03-10T14:33:04Z Journal Article https://hdl.handle.net/10568/129300 en Open Access Oxford University Press Deloria Knoll, Maria; Morpeth, Susan C.; Scott, J.Anthony G.; Watson, Nora L.; Park, Daniel E.; Baggett, Henry C.; Brooks, W. Abdullah; Feikin, Daniel R.; Hammitt, Laura L.; Howie, Stephen R.C.; Kotloff, Karen L.; Levine, Orin S.; O'Brien, Katherine L.; Thea, Donald M.; Ahmed, Dilruba; Antonio, Martin; Awori, Juliet O.; Baillie, Vicky L.; Chipeta, James; Deluca, Andrea N.; Dione, Michel M.; Driscoll, Amanda J.; Higdon, Melissa M.; Jatapai, Anchalee; Karron, Ruth A.; Mazumder, Razib; Moore, David P.; Mwansa, James; Nyongesa, Sammy; Prosperi, Christine; Seidenberg, Phil; Siludjai, Duangkamon; Sow, Samba O.; Tamboura, Boubou; Zeger, Scott L.; Murdoch, David R.; Madhi, Shabir A.; Knoll, Maria Deloria; Deluca, Andrea N.; Fancourt, Nicholas; Fu, Wei; Kagucia, E.Wangeci; Li, Mengying; Wu, Zhenke; Crawley, Jane; Endtz, Hubert P.; Zaman, Khalequ; Goswami, Doli; Hossain, Lokman; Jahan, Yasmin; Ashraf, Hasan; Ebruke, Bernard E.; McLellan, Jessica; Machuka, Eunice M.; Shamsul, Arifin; Zaman, Syed M.A.; Mackenzie, Grant; Kamau, Alice; Kazungu, Sidi; Ominde, Micah Silaba; Tapia, Milagritos D.; Sylla, Mamadou; Onwuchekwa, Uma; Kourouma, Nana; Toure, Aliou; Adrian, Peter V.; Kuwanda, Locadiah; Mudau, Azwifarwi; Groome, Michelle J.; Mahomed, Nasreen; Thamthitiwat, Somsak; Maloney, Susan A.; Bunthi, Charatdao; Rhodes, Julia; Sawatwong, Pongpun; Akarasewi, Pasakorn; Mwananyanda, Lawrence; Wa Somwe, Somwe; Kwenda, Geoffrey; Anderson, Trevor P.; Mitchell, Joanne. 2017. Evaluation of Pneumococcal Load in Blood by Polymerase Chain Reaction for the Diagnosis of Pneumococcal Pneumonia in Young Children in the PERCH Study. Clinical Infectious Diseases 64: S357-S367 |
| spellingShingle | evaluation diagnosis children blood polymerase chain reaction pneumonia Deloria Knoll, Maria Morpeth, Susan C. Scott, J.Anthony G. Watson, Nora L. Park, Daniel E. Baggett, Henry C. Brooks, W. Abdullah Feikin, Daniel R. Hammitt, Laura L. Howie, Stephen R.C. Kotloff, Karen L. Levine, Orin S. O’Brien, Katherine L. Thea, Donald M. Ahmed, Dilruba Antonio, Martin Awori, Juliet O. Baillie, Vicky L. Chipeta, James Deluca, Andrea N. Dione, Michel M. Driscoll, Amanda J. Higdon, Melissa M. Jatapai, Anchalee Karron, Ruth A. Mazumder, Razib Moore, David P. Mwansa, James Nyongesa, Sammy Prosperi, Christine Seidenberg, Phil Siludjai, Duangkamon Sow, Samba O. Tamboura, Boubou Zeger, Scott L. Murdoch, David R. Madhi, Shabir A. Knoll, Maria Deloria Fancourt, Nicholas Fu, Wei Kagucia, E.Wangeci Li, Mengying Wu, Zhenke Crawley, Jane Endtz, Hubert P. Zaman, Khalequ Goswami, Doli Hossain, Lokman Jahan, Yasmin Ashraf, Hasan Ebruke, Bernard E. McLellan, Jessica Machuka, Eunice M. Shamsul, Arifin Zaman, Syed M.A. Mackenzie, Grant Kamau, Alice Kazungu, Sidi Ominde, Micah Silaba Tapia, Milagritos D. Sylla, Mamadou Onwuchekwa, Uma Kourouma, Nana Touré, Aliou Adrian, Peter V. Kuwanda, Locadiah Mudau, Azwifarwi Groome, Michelle J. Mahomed, Nasreen Thamthitiwat, Somsak Maloney, Susan A. Bunthi, Charatdao Rhodes, Julia Sawatwong, Pongpun Akarasewi, Pasakorn Mwananyanda, Lawrence Wa Somwe, Somwe Kwenda, Geoffrey Anderson, Trevor P. Mitchell, Joanne Evaluation of Pneumococcal Load in Blood by Polymerase Chain Reaction for the Diagnosis of Pneumococcal Pneumonia in Young Children in the PERCH Study |
| title | Evaluation of Pneumococcal Load in Blood by Polymerase Chain Reaction for the Diagnosis of Pneumococcal Pneumonia in Young Children in the PERCH Study |
| title_full | Evaluation of Pneumococcal Load in Blood by Polymerase Chain Reaction for the Diagnosis of Pneumococcal Pneumonia in Young Children in the PERCH Study |
| title_fullStr | Evaluation of Pneumococcal Load in Blood by Polymerase Chain Reaction for the Diagnosis of Pneumococcal Pneumonia in Young Children in the PERCH Study |
| title_full_unstemmed | Evaluation of Pneumococcal Load in Blood by Polymerase Chain Reaction for the Diagnosis of Pneumococcal Pneumonia in Young Children in the PERCH Study |
| title_short | Evaluation of Pneumococcal Load in Blood by Polymerase Chain Reaction for the Diagnosis of Pneumococcal Pneumonia in Young Children in the PERCH Study |
| title_sort | evaluation of pneumococcal load in blood by polymerase chain reaction for the diagnosis of pneumococcal pneumonia in young children in the perch study |
| topic | evaluation diagnosis children blood polymerase chain reaction pneumonia |
| url | https://hdl.handle.net/10568/129300 |
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