The impact of co-infections on the haematological profile of East African Short-horn Zebu calves
The cumulative effect of co-infections between pathogen pairs on the haematological response of East African Short-horn Zebu calves is described. Using a longitudinal study design a stratified clustered random sample of newborn calves were recruited into the Infectious Diseases of East African Lives...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Cambridge University Press
2014
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/129276 |
| _version_ | 1855538086932381696 |
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| author | Wyk, Ilana Conradie van Goddard, Amelia Bronsvoort, B.M. de C. Coetzer, Jacobus A.W. Handel, Ian G. Hanotte, Olivier H. Jennings, Amy Lesosky, Maia Kiara, Henry K. Thumbi, Samuel M. Toye, Philip G. Woolhouse, Mark E.J. Penzhorn, Banie L. |
| author_browse | Bronsvoort, B.M. de C. Coetzer, Jacobus A.W. Goddard, Amelia Handel, Ian G. Hanotte, Olivier H. Jennings, Amy Kiara, Henry K. Lesosky, Maia Penzhorn, Banie L. Thumbi, Samuel M. Toye, Philip G. Woolhouse, Mark E.J. Wyk, Ilana Conradie van |
| author_facet | Wyk, Ilana Conradie van Goddard, Amelia Bronsvoort, B.M. de C. Coetzer, Jacobus A.W. Handel, Ian G. Hanotte, Olivier H. Jennings, Amy Lesosky, Maia Kiara, Henry K. Thumbi, Samuel M. Toye, Philip G. Woolhouse, Mark E.J. Penzhorn, Banie L. |
| author_sort | Wyk, Ilana Conradie van |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | The cumulative effect of co-infections between pathogen pairs on the haematological response of East African Short-horn Zebu calves is described. Using a longitudinal study design a stratified clustered random sample of newborn calves were recruited into the Infectious Diseases of East African Livestock (IDEAL) study and monitored at 5-weekly intervals until 51 weeks of age. At each visit samples were collected and analysed to determine the infection status of each calf as well as their haematological response. The haematological parameters investigated included packed cell volume (PCV), white blood cell count (WBC) and platelet count (Plt). The pathogens of interest included tick-borne protozoa and rickettsias, trypanosomes and intestinal parasites. Generalized additive mixed-effect models were used to model the infectious status of pathogens against each haematological parameter, including significant interactions between pathogens. These models were further used to predict the cumulative effect of co-infecting pathogen pairs on each haematological parameter. The most significant decrease in PCV was found with co-infections of trypanosomes and strongyles. Strongyle infections also resulted in a significant decrease in WBC at a high infectious load. Trypanosomes were the major cause of thrombocytopenia. Platelet counts were also affected by interactions between tick-borne pathogens. Interactions between concomitant pathogens were found to complicate the prognosis and clinical presentation of infected calves and should be taken into consideration in any study that investigates disease under field conditions. |
| format | Journal Article |
| id | CGSpace129276 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2014 |
| publishDateRange | 2014 |
| publishDateSort | 2014 |
| publisher | Cambridge University Press |
| publisherStr | Cambridge University Press |
| record_format | dspace |
| spelling | CGSpace1292762024-08-27T10:37:02Z The impact of co-infections on the haematological profile of East African Short-horn Zebu calves Wyk, Ilana Conradie van Goddard, Amelia Bronsvoort, B.M. de C. Coetzer, Jacobus A.W. Handel, Ian G. Hanotte, Olivier H. Jennings, Amy Lesosky, Maia Kiara, Henry K. Thumbi, Samuel M. Toye, Philip G. Woolhouse, Mark E.J. Penzhorn, Banie L. calves zebu The cumulative effect of co-infections between pathogen pairs on the haematological response of East African Short-horn Zebu calves is described. Using a longitudinal study design a stratified clustered random sample of newborn calves were recruited into the Infectious Diseases of East African Livestock (IDEAL) study and monitored at 5-weekly intervals until 51 weeks of age. At each visit samples were collected and analysed to determine the infection status of each calf as well as their haematological response. The haematological parameters investigated included packed cell volume (PCV), white blood cell count (WBC) and platelet count (Plt). The pathogens of interest included tick-borne protozoa and rickettsias, trypanosomes and intestinal parasites. Generalized additive mixed-effect models were used to model the infectious status of pathogens against each haematological parameter, including significant interactions between pathogens. These models were further used to predict the cumulative effect of co-infecting pathogen pairs on each haematological parameter. The most significant decrease in PCV was found with co-infections of trypanosomes and strongyles. Strongyle infections also resulted in a significant decrease in WBC at a high infectious load. Trypanosomes were the major cause of thrombocytopenia. Platelet counts were also affected by interactions between tick-borne pathogens. Interactions between concomitant pathogens were found to complicate the prognosis and clinical presentation of infected calves and should be taken into consideration in any study that investigates disease under field conditions. 2014-03 2023-03-10T14:32:55Z 2023-03-10T14:32:55Z Journal Article https://hdl.handle.net/10568/129276 en Open Access Cambridge University Press Wyk, Ilana Conradie van; Goddard, Amelia; Bronsvoort, B.M. de C.; Coetzer, Jacobus A.W.; Handel, Ian G.; Hanotte, Olivier H.; Jennings, Amy; Lesosky, Maia; Kiara, Henry K.; Thumbi, Sam M.; Toye, Philip G.; Woolhouse, Mark E.J.; Penzhorn, Banie L. 2014. The impact of co-infections on the haematological profile of East African Short-horn Zebu calves. Parasitology 141: 374-388 |
| spellingShingle | calves zebu Wyk, Ilana Conradie van Goddard, Amelia Bronsvoort, B.M. de C. Coetzer, Jacobus A.W. Handel, Ian G. Hanotte, Olivier H. Jennings, Amy Lesosky, Maia Kiara, Henry K. Thumbi, Samuel M. Toye, Philip G. Woolhouse, Mark E.J. Penzhorn, Banie L. The impact of co-infections on the haematological profile of East African Short-horn Zebu calves |
| title | The impact of co-infections on the haematological profile of East African Short-horn Zebu calves |
| title_full | The impact of co-infections on the haematological profile of East African Short-horn Zebu calves |
| title_fullStr | The impact of co-infections on the haematological profile of East African Short-horn Zebu calves |
| title_full_unstemmed | The impact of co-infections on the haematological profile of East African Short-horn Zebu calves |
| title_short | The impact of co-infections on the haematological profile of East African Short-horn Zebu calves |
| title_sort | impact of co infections on the haematological profile of east african short horn zebu calves |
| topic | calves zebu |
| url | https://hdl.handle.net/10568/129276 |
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