Genome variation in tick infestation and cryptic divergence in Tunisian indigenous sheep
Background: Ticks are obligate haematophagous ectoparasites considered second to mosquitos as vectors and reservoirs of multiple pathogens of global concern. Individual variation in tick infestation has been reported in indigenous sheep, but its genetic control remains unknown. Results: Here, we rep...
| Main Authors: | , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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BioMed Central
2023
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/127318 |
| _version_ | 1855521333023080448 |
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| author | Ahbara, Abulgasim Khbou, Médiha Khamassi Romdhane, Rihab Sassi, Limam Gharbi, Mohamed Haile, Aynalem Rekik, Mourad Rischkowsky, Barbara Mwacharo, Joram |
| author_browse | Ahbara, Abulgasim Gharbi, Mohamed Haile, Aynalem Khbou, Médiha Khamassi Mwacharo, Joram Rekik, Mourad Rischkowsky, Barbara Romdhane, Rihab Sassi, Limam |
| author_facet | Ahbara, Abulgasim Khbou, Médiha Khamassi Romdhane, Rihab Sassi, Limam Gharbi, Mohamed Haile, Aynalem Rekik, Mourad Rischkowsky, Barbara Mwacharo, Joram |
| author_sort | Ahbara, Abulgasim |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Background: Ticks are obligate haematophagous ectoparasites considered second to mosquitos as vectors and reservoirs of multiple pathogens of global concern. Individual variation in tick infestation has been reported in indigenous sheep, but its genetic control remains unknown.
Results: Here, we report 397 genome-wide signatures of selection overlapping 991 genes from the analysis, using four methods (ROH, LR-GWAS, XP-EHH, FST), of 600K SNP genotype data from 165 Tunisian sheep exhibiting high and low tick infestations and piroplasm infections. We considered 45 signatures that were detected by consensus results of at least two methods as high-confidence selection sweep regions. These spanned 104 genes which included immune system function genes, solute carriers and chemokine receptor. One region spanned STX5, that has been associated with tick resistance in cattle, implicating it as a prime candidate in sheep. We also observed RAB6B and TF in a high confidence candidate region that has been associated with growth traits suggesting natural selection is enhancing growth and developmental stability under tick challenge. The analysis also revealed fine-scale genome structure suggesting cryptic divergence in Tunisian sheep.
Conclusion: Our findings provide a genomic reference that can enhance understanding of the genetic architecture of tick resistance and cryptic divergence in indigenous African sheep. |
| format | Journal Article |
| id | CGSpace127318 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | BioMed Central |
| publisherStr | BioMed Central |
| record_format | dspace |
| spelling | CGSpace1273182026-01-22T02:04:59Z Genome variation in tick infestation and cryptic divergence in Tunisian indigenous sheep Ahbara, Abulgasim Khbou, Médiha Khamassi Romdhane, Rihab Sassi, Limam Gharbi, Mohamed Haile, Aynalem Rekik, Mourad Rischkowsky, Barbara Mwacharo, Joram tunisia goal 1 no poverty sheep genome variation tick infestation cryptic divergence poverty reduction, livelihoods and jobs Background: Ticks are obligate haematophagous ectoparasites considered second to mosquitos as vectors and reservoirs of multiple pathogens of global concern. Individual variation in tick infestation has been reported in indigenous sheep, but its genetic control remains unknown. Results: Here, we report 397 genome-wide signatures of selection overlapping 991 genes from the analysis, using four methods (ROH, LR-GWAS, XP-EHH, FST), of 600K SNP genotype data from 165 Tunisian sheep exhibiting high and low tick infestations and piroplasm infections. We considered 45 signatures that were detected by consensus results of at least two methods as high-confidence selection sweep regions. These spanned 104 genes which included immune system function genes, solute carriers and chemokine receptor. One region spanned STX5, that has been associated with tick resistance in cattle, implicating it as a prime candidate in sheep. We also observed RAB6B and TF in a high confidence candidate region that has been associated with growth traits suggesting natural selection is enhancing growth and developmental stability under tick challenge. The analysis also revealed fine-scale genome structure suggesting cryptic divergence in Tunisian sheep. Conclusion: Our findings provide a genomic reference that can enhance understanding of the genetic architecture of tick resistance and cryptic divergence in indigenous African sheep. 2023-01-17T15:35:55Z 2023-01-17T15:35:55Z Journal Article https://hdl.handle.net/10568/127318 en Open Access application/pdf BioMed Central Abulgasim Ahbara, Médiha Khamassi Khbou, Rihab Romdhane, Limam Sassi, Mohamed Gharbi, Aynalem Haile, Mourad Rekik, Barbara Rischkowsky, Joram Mwacharo. (28/2/2022). Genome variation in tick infestation and cryptic divergence in Tunisian indigenous sheep. BMC Genomics, 167 (23). |
| spellingShingle | tunisia goal 1 no poverty sheep genome variation tick infestation cryptic divergence poverty reduction, livelihoods and jobs Ahbara, Abulgasim Khbou, Médiha Khamassi Romdhane, Rihab Sassi, Limam Gharbi, Mohamed Haile, Aynalem Rekik, Mourad Rischkowsky, Barbara Mwacharo, Joram Genome variation in tick infestation and cryptic divergence in Tunisian indigenous sheep |
| title | Genome variation in tick infestation and cryptic divergence in Tunisian indigenous sheep |
| title_full | Genome variation in tick infestation and cryptic divergence in Tunisian indigenous sheep |
| title_fullStr | Genome variation in tick infestation and cryptic divergence in Tunisian indigenous sheep |
| title_full_unstemmed | Genome variation in tick infestation and cryptic divergence in Tunisian indigenous sheep |
| title_short | Genome variation in tick infestation and cryptic divergence in Tunisian indigenous sheep |
| title_sort | genome variation in tick infestation and cryptic divergence in tunisian indigenous sheep |
| topic | tunisia goal 1 no poverty sheep genome variation tick infestation cryptic divergence poverty reduction, livelihoods and jobs |
| url | https://hdl.handle.net/10568/127318 |
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