Genome-wide association study identifies loci and candidate genes for grain micronutrients and quality traits in wheat (Triticum aestivum L.)
Malnutrition due to micronutrients and protein deficiency is recognized among the major global health issues. Genetic biofortification of wheat is a cost-effective and sustainable strategy to mitigate the global micronutrient and protein malnutrition. Genomic regions governing grain zinc concentrati...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Springer
2022
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| Online Access: | https://hdl.handle.net/10568/126597 |
| _version_ | 1855528664697929728 |
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| author | Rathan, Nagenahalli Dharmegowda Krishna, Hari Ellur, Ranjith Kumar Sehgal, Deepmala Velu, Govindan Ahlawat, Arvind Kumar Krishnappa, Gopalareddy Jaiswal, Jai Prakash Singh, Jang Bahadur Saiprasad, S.V. Ambati, Divya Singh, Sumit Kumar Bajpai, Kriti Mahendru-Singh, Anju |
| author_browse | Ahlawat, Arvind Kumar Ambati, Divya Bajpai, Kriti Ellur, Ranjith Kumar Jaiswal, Jai Prakash Krishna, Hari Krishnappa, Gopalareddy Mahendru-Singh, Anju Rathan, Nagenahalli Dharmegowda Saiprasad, S.V. Sehgal, Deepmala Singh, Jang Bahadur Singh, Sumit Kumar Velu, Govindan |
| author_facet | Rathan, Nagenahalli Dharmegowda Krishna, Hari Ellur, Ranjith Kumar Sehgal, Deepmala Velu, Govindan Ahlawat, Arvind Kumar Krishnappa, Gopalareddy Jaiswal, Jai Prakash Singh, Jang Bahadur Saiprasad, S.V. Ambati, Divya Singh, Sumit Kumar Bajpai, Kriti Mahendru-Singh, Anju |
| author_sort | Rathan, Nagenahalli Dharmegowda |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Malnutrition due to micronutrients and protein deficiency is recognized among the major global health issues. Genetic biofortification of wheat is a cost-effective and sustainable strategy to mitigate the global micronutrient and protein malnutrition. Genomic regions governing grain zinc concentration (GZnC), grain iron concentration (GFeC), grain protein content (GPC), test weight (TW), and thousand kernel weight (TKW) were investigated in a set of 184 diverse bread wheat genotypes through genome-wide association study (GWAS). The GWAS panel was genotyped using Breeders' 35 K Axiom Array and phenotyped in three different environments during 2019–2020. A total of 55 marker-trait associations (MTAs) were identified representing all three sub-genomes of wheat. The highest number of MTAs were identified for GPC (23), followed by TKW (15), TW (11), GFeC (4), and GZnC (2). Further, a stable SNP was identified for TKW, and also pleiotropic regions were identified for GPC and TKW. In silico analysis revealed important putative candidate genes underlying the identified genomic regions such as F-box-like domain superfamily, Zinc finger CCCH-type proteins, Serine-threonine/tyrosine-protein kinase, Histone deacetylase domain superfamily, and SANT/Myb domain superfamily proteins, etc. The identified novel MTAs will be validated to estimate their effects in different genetic backgrounds for subsequent use in marker-assisted selection. |
| format | Journal Article |
| id | CGSpace126597 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace1265972025-12-08T09:54:28Z Genome-wide association study identifies loci and candidate genes for grain micronutrients and quality traits in wheat (Triticum aestivum L.) Rathan, Nagenahalli Dharmegowda Krishna, Hari Ellur, Ranjith Kumar Sehgal, Deepmala Velu, Govindan Ahlawat, Arvind Kumar Krishnappa, Gopalareddy Jaiswal, Jai Prakash Singh, Jang Bahadur Saiprasad, S.V. Ambati, Divya Singh, Sumit Kumar Bajpai, Kriti Mahendru-Singh, Anju malnutrition biofortification wheat quality Malnutrition due to micronutrients and protein deficiency is recognized among the major global health issues. Genetic biofortification of wheat is a cost-effective and sustainable strategy to mitigate the global micronutrient and protein malnutrition. Genomic regions governing grain zinc concentration (GZnC), grain iron concentration (GFeC), grain protein content (GPC), test weight (TW), and thousand kernel weight (TKW) were investigated in a set of 184 diverse bread wheat genotypes through genome-wide association study (GWAS). The GWAS panel was genotyped using Breeders' 35 K Axiom Array and phenotyped in three different environments during 2019–2020. A total of 55 marker-trait associations (MTAs) were identified representing all three sub-genomes of wheat. The highest number of MTAs were identified for GPC (23), followed by TKW (15), TW (11), GFeC (4), and GZnC (2). Further, a stable SNP was identified for TKW, and also pleiotropic regions were identified for GPC and TKW. In silico analysis revealed important putative candidate genes underlying the identified genomic regions such as F-box-like domain superfamily, Zinc finger CCCH-type proteins, Serine-threonine/tyrosine-protein kinase, Histone deacetylase domain superfamily, and SANT/Myb domain superfamily proteins, etc. The identified novel MTAs will be validated to estimate their effects in different genetic backgrounds for subsequent use in marker-assisted selection. 2022-04-29 2023-01-05T09:09:10Z 2023-01-05T09:09:10Z Journal Article https://hdl.handle.net/10568/126597 en Open Access application/pdf Springer Rathan, N. D., Krishna, H., Ellur, R. K., Sehgal, D., Govindan, V., Ahlawat, A. K., Krishnappa, G., Jaiswal, J. P., Singh, J. B., SV, S., Ambati, D., Singh, S. K., Bajpai, K., & Mahendru-Singh, A. (2022). Genome-wide association study identifies loci and candidate genes for grain micronutrients and quality traits in wheat (Triticum aestivum L.). Scientific Reports, 12(1). https://doi.org/10.1038/s41598-022-10618-w |
| spellingShingle | malnutrition biofortification wheat quality Rathan, Nagenahalli Dharmegowda Krishna, Hari Ellur, Ranjith Kumar Sehgal, Deepmala Velu, Govindan Ahlawat, Arvind Kumar Krishnappa, Gopalareddy Jaiswal, Jai Prakash Singh, Jang Bahadur Saiprasad, S.V. Ambati, Divya Singh, Sumit Kumar Bajpai, Kriti Mahendru-Singh, Anju Genome-wide association study identifies loci and candidate genes for grain micronutrients and quality traits in wheat (Triticum aestivum L.) |
| title | Genome-wide association study identifies loci and candidate genes for grain micronutrients and quality traits in wheat (Triticum aestivum L.) |
| title_full | Genome-wide association study identifies loci and candidate genes for grain micronutrients and quality traits in wheat (Triticum aestivum L.) |
| title_fullStr | Genome-wide association study identifies loci and candidate genes for grain micronutrients and quality traits in wheat (Triticum aestivum L.) |
| title_full_unstemmed | Genome-wide association study identifies loci and candidate genes for grain micronutrients and quality traits in wheat (Triticum aestivum L.) |
| title_short | Genome-wide association study identifies loci and candidate genes for grain micronutrients and quality traits in wheat (Triticum aestivum L.) |
| title_sort | genome wide association study identifies loci and candidate genes for grain micronutrients and quality traits in wheat triticum aestivum l |
| topic | malnutrition biofortification wheat quality |
| url | https://hdl.handle.net/10568/126597 |
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