Genomic analysis of 10 years of artificial selection in community-based breeding programs in two Ethiopian indigenous sheep breeds
In recent times, community-based breeding programs (CBBPs) have been advocated as the best strategy for genetic improvement of local breeds in smallholder farms in developing countries. Since 2009, CBBPs have been implemented for Ethiopian Bonga and Menz sheep t...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
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Wiley
2022
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/126564 |
| _version_ | 1855537278596677632 |
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| author | Rekik, Emna Ahbara, Abulgasim Abate, Zelalem Goshme, Shenkute Getachew, Tesfaye Haile, Aynalem Rischkowsky, Barbara Mwacharo, Joram |
| author_browse | Abate, Zelalem Ahbara, Abulgasim Getachew, Tesfaye Goshme, Shenkute Haile, Aynalem Mwacharo, Joram Rekik, Emna Rischkowsky, Barbara |
| author_facet | Rekik, Emna Ahbara, Abulgasim Abate, Zelalem Goshme, Shenkute Getachew, Tesfaye Haile, Aynalem Rischkowsky, Barbara Mwacharo, Joram |
| author_sort | Rekik, Emna |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | In recent times, community-based breeding programs (CBBPs) have been advocated as the best strategy for genetic improvement of local breeds in smallholder farms in developing countries. Since 2009, CBBPs have been implemented for Ethiopian Bonga and Menz sheep to improve growth rates resulting in significant genetic gains in 6-month weights. With the hypothesis that selection could be impacting their genomes, we systematically screened for possible genome changes in the two breeds by analyzing 600K BeadChip genotype data of 151 individuals (with the highest breeding values for 6-month weights) from CBBP f locks against 98 individuals from non-CBBP f locks. We observed no differences in genetic diversity and demographic dynamics between CBBP and non-CBBP f locks. Selection signature analysis employing ROH, logistic regression genome-wide association study, FST, XP-EHH and iHS revealed 5 (Bonga) and 11 (Menz) overlapping regions under selection, that co-localized with QTLs for production (body size/weight, growth, milk yield), meat/milk quality, and health/parasite resistance, suggesting that the decade- long selection has likely started to impact their genomes. However, genome- wide genetic differentiation between the CBBP and non-CBBP f locks is not yet clearly evident. |
| format | Journal Article |
| id | CGSpace126564 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace1265642026-01-14T02:14:48Z Genomic analysis of 10 years of artificial selection in community-based breeding programs in two Ethiopian indigenous sheep breeds Rekik, Emna Ahbara, Abulgasim Abate, Zelalem Goshme, Shenkute Getachew, Tesfaye Haile, Aynalem Rischkowsky, Barbara Mwacharo, Joram sheep genetic improvement breeds ovis aries selection signatures goal 1 no poverty sheep diversity genome-wide menz bonga poverty reduction, livelihoods and jobs In recent times, community-based breeding programs (CBBPs) have been advocated as the best strategy for genetic improvement of local breeds in smallholder farms in developing countries. Since 2009, CBBPs have been implemented for Ethiopian Bonga and Menz sheep to improve growth rates resulting in significant genetic gains in 6-month weights. With the hypothesis that selection could be impacting their genomes, we systematically screened for possible genome changes in the two breeds by analyzing 600K BeadChip genotype data of 151 individuals (with the highest breeding values for 6-month weights) from CBBP f locks against 98 individuals from non-CBBP f locks. We observed no differences in genetic diversity and demographic dynamics between CBBP and non-CBBP f locks. Selection signature analysis employing ROH, logistic regression genome-wide association study, FST, XP-EHH and iHS revealed 5 (Bonga) and 11 (Menz) overlapping regions under selection, that co-localized with QTLs for production (body size/weight, growth, milk yield), meat/milk quality, and health/parasite resistance, suggesting that the decade- long selection has likely started to impact their genomes. However, genome- wide genetic differentiation between the CBBP and non-CBBP f locks is not yet clearly evident. 2022-06-01 2023-01-04T18:18:01Z 2023-01-04T18:18:01Z Journal Article https://hdl.handle.net/10568/126564 en Open Access application/pdf Wiley Emna Rekik, Abulgasim Ahbara, Zelalem Abate, Shenkute Goshme, Tesfaye Getachew, Aynalem Haile, Barbara Rischkowsky, Joram Mwacharo. (1/6/2022). Genomic analysis of 10 years of artificial selection in community-based breeding programs in two Ethiopian indigenous sheep breeds. Animal Genetics, 53 (3), pp. 447-451. |
| spellingShingle | sheep genetic improvement breeds ovis aries selection signatures goal 1 no poverty sheep diversity genome-wide menz bonga poverty reduction, livelihoods and jobs Rekik, Emna Ahbara, Abulgasim Abate, Zelalem Goshme, Shenkute Getachew, Tesfaye Haile, Aynalem Rischkowsky, Barbara Mwacharo, Joram Genomic analysis of 10 years of artificial selection in community-based breeding programs in two Ethiopian indigenous sheep breeds |
| title | Genomic analysis of 10 years of artificial selection in community-based breeding programs in two Ethiopian indigenous sheep breeds |
| title_full | Genomic analysis of 10 years of artificial selection in community-based breeding programs in two Ethiopian indigenous sheep breeds |
| title_fullStr | Genomic analysis of 10 years of artificial selection in community-based breeding programs in two Ethiopian indigenous sheep breeds |
| title_full_unstemmed | Genomic analysis of 10 years of artificial selection in community-based breeding programs in two Ethiopian indigenous sheep breeds |
| title_short | Genomic analysis of 10 years of artificial selection in community-based breeding programs in two Ethiopian indigenous sheep breeds |
| title_sort | genomic analysis of 10 years of artificial selection in community based breeding programs in two ethiopian indigenous sheep breeds |
| topic | sheep genetic improvement breeds ovis aries selection signatures goal 1 no poverty sheep diversity genome-wide menz bonga poverty reduction, livelihoods and jobs |
| url | https://hdl.handle.net/10568/126564 |
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