Maize Lethal Necrosis disease: review of molecular and genetic resistance mechanisms, socio-economic impacts, and mitigation strategies in sub-Saharan Africa
Background: Maize lethal necrosis (MLN) disease is a significant constraint for maize producers in sub-Saharan Africa (SSA). The disease decimates the maize crop, in some cases, causing total crop failure with far-reaching impacts on regional food security. Results: In this review, we analyze the im...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Springer
2022
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/126546 |
| _version_ | 1855516159351193600 |
|---|---|
| author | Biswal, Akshaya Kumar Alakonya, Amos Mottaleb, Khondoker Abdul Hearne, Sarah Jane Sonder, Kai Molnar, Terence Luke Jones, Alan M. Pixley, Kevin Vail Boddupalli, P.M. |
| author_browse | Alakonya, Amos Biswal, Akshaya Kumar Boddupalli, P.M. Hearne, Sarah Jane Jones, Alan M. Molnar, Terence Luke Mottaleb, Khondoker Abdul Pixley, Kevin Vail Sonder, Kai |
| author_facet | Biswal, Akshaya Kumar Alakonya, Amos Mottaleb, Khondoker Abdul Hearne, Sarah Jane Sonder, Kai Molnar, Terence Luke Jones, Alan M. Pixley, Kevin Vail Boddupalli, P.M. |
| author_sort | Biswal, Akshaya Kumar |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Background: Maize lethal necrosis (MLN) disease is a significant constraint for maize producers in sub-Saharan Africa (SSA). The disease decimates the maize crop, in some cases, causing total crop failure with far-reaching impacts on regional food security. Results: In this review, we analyze the impacts of MLN in Africa, finding that resource-poor farmers and consumers are the most vulnerable populations. We examine the molecular mechanism of MLN virus transmission, role of vectors and host plant resistance identifying a range of potential opportunities for genetic and phytosanitary interventions to control MLN. We discuss the likely exacerbating effects of climate change on the MLN menace and describe a sobering example of negative genetic association between tolerance to heat/drought and susceptibility to viral infection. We also review role of microRNAs in host plant response to MLN causing viruses as well as heat/drought stress that can be carefully engineered to develop resistant varieties using novel molecular techniques. Conclusions: With the dual drivers of increased crop loss due to MLN and increased demand of maize for food, the development and deployment of simple and safe technologies, like resistant cultivars developed through accelerated breeding or emerging gene editing technologies, will have substantial positive impact on livelihoods in the region. We have summarized the available genetic resources and identified a few large-effect QTLs that can be further exploited to accelerate conversion of existing farmer-preferred varieties into resistant cultivars. |
| format | Journal Article |
| id | CGSpace126546 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace1265462025-11-06T13:03:14Z Maize Lethal Necrosis disease: review of molecular and genetic resistance mechanisms, socio-economic impacts, and mitigation strategies in sub-Saharan Africa Biswal, Akshaya Kumar Alakonya, Amos Mottaleb, Khondoker Abdul Hearne, Sarah Jane Sonder, Kai Molnar, Terence Luke Jones, Alan M. Pixley, Kevin Vail Boddupalli, P.M. drought stress gene editing maize necrosis potyvirus quantitative trait loci Background: Maize lethal necrosis (MLN) disease is a significant constraint for maize producers in sub-Saharan Africa (SSA). The disease decimates the maize crop, in some cases, causing total crop failure with far-reaching impacts on regional food security. Results: In this review, we analyze the impacts of MLN in Africa, finding that resource-poor farmers and consumers are the most vulnerable populations. We examine the molecular mechanism of MLN virus transmission, role of vectors and host plant resistance identifying a range of potential opportunities for genetic and phytosanitary interventions to control MLN. We discuss the likely exacerbating effects of climate change on the MLN menace and describe a sobering example of negative genetic association between tolerance to heat/drought and susceptibility to viral infection. We also review role of microRNAs in host plant response to MLN causing viruses as well as heat/drought stress that can be carefully engineered to develop resistant varieties using novel molecular techniques. Conclusions: With the dual drivers of increased crop loss due to MLN and increased demand of maize for food, the development and deployment of simple and safe technologies, like resistant cultivars developed through accelerated breeding or emerging gene editing technologies, will have substantial positive impact on livelihoods in the region. We have summarized the available genetic resources and identified a few large-effect QTLs that can be further exploited to accelerate conversion of existing farmer-preferred varieties into resistant cultivars. 2022-11-23 2023-01-04T12:01:44Z 2023-01-04T12:01:44Z Journal Article https://hdl.handle.net/10568/126546 en Open Access application/pdf Springer Biswal, A. K., Alakonya, A. E., Mottaleb, K. A., Hearne, S. J., Sonder, K., Molnar, T. L., Jones, A. M., Pixley, K. V., & Prasanna, B. M. (2022). Maize Lethal Necrosis disease: review of molecular and genetic resistance mechanisms, socio-economic impacts, and mitigation strategies in sub-Saharan Africa. BMC Plant Biology, 22(1). https://doi.org/10.1186/s12870-022-03932-y |
| spellingShingle | drought stress gene editing maize necrosis potyvirus quantitative trait loci Biswal, Akshaya Kumar Alakonya, Amos Mottaleb, Khondoker Abdul Hearne, Sarah Jane Sonder, Kai Molnar, Terence Luke Jones, Alan M. Pixley, Kevin Vail Boddupalli, P.M. Maize Lethal Necrosis disease: review of molecular and genetic resistance mechanisms, socio-economic impacts, and mitigation strategies in sub-Saharan Africa |
| title | Maize Lethal Necrosis disease: review of molecular and genetic resistance mechanisms, socio-economic impacts, and mitigation strategies in sub-Saharan Africa |
| title_full | Maize Lethal Necrosis disease: review of molecular and genetic resistance mechanisms, socio-economic impacts, and mitigation strategies in sub-Saharan Africa |
| title_fullStr | Maize Lethal Necrosis disease: review of molecular and genetic resistance mechanisms, socio-economic impacts, and mitigation strategies in sub-Saharan Africa |
| title_full_unstemmed | Maize Lethal Necrosis disease: review of molecular and genetic resistance mechanisms, socio-economic impacts, and mitigation strategies in sub-Saharan Africa |
| title_short | Maize Lethal Necrosis disease: review of molecular and genetic resistance mechanisms, socio-economic impacts, and mitigation strategies in sub-Saharan Africa |
| title_sort | maize lethal necrosis disease review of molecular and genetic resistance mechanisms socio economic impacts and mitigation strategies in sub saharan africa |
| topic | drought stress gene editing maize necrosis potyvirus quantitative trait loci |
| url | https://hdl.handle.net/10568/126546 |
| work_keys_str_mv | AT biswalakshayakumar maizelethalnecrosisdiseasereviewofmolecularandgeneticresistancemechanismssocioeconomicimpactsandmitigationstrategiesinsubsaharanafrica AT alakonyaamos maizelethalnecrosisdiseasereviewofmolecularandgeneticresistancemechanismssocioeconomicimpactsandmitigationstrategiesinsubsaharanafrica AT mottalebkhondokerabdul maizelethalnecrosisdiseasereviewofmolecularandgeneticresistancemechanismssocioeconomicimpactsandmitigationstrategiesinsubsaharanafrica AT hearnesarahjane maizelethalnecrosisdiseasereviewofmolecularandgeneticresistancemechanismssocioeconomicimpactsandmitigationstrategiesinsubsaharanafrica AT sonderkai maizelethalnecrosisdiseasereviewofmolecularandgeneticresistancemechanismssocioeconomicimpactsandmitigationstrategiesinsubsaharanafrica AT molnarterenceluke maizelethalnecrosisdiseasereviewofmolecularandgeneticresistancemechanismssocioeconomicimpactsandmitigationstrategiesinsubsaharanafrica AT jonesalanm maizelethalnecrosisdiseasereviewofmolecularandgeneticresistancemechanismssocioeconomicimpactsandmitigationstrategiesinsubsaharanafrica AT pixleykevinvail maizelethalnecrosisdiseasereviewofmolecularandgeneticresistancemechanismssocioeconomicimpactsandmitigationstrategiesinsubsaharanafrica AT boddupallipm maizelethalnecrosisdiseasereviewofmolecularandgeneticresistancemechanismssocioeconomicimpactsandmitigationstrategiesinsubsaharanafrica |