Whole-genome resequencing of Dorper and Hu sheep to reveal selection signatures associated with important traits
Dorper and Hu sheep exhibit different characteristics in terms of reproduction, growth, and meat quality. Comparison of the genomes of two breeds help to reveal important genomic information. In this study, whole genome resequencing of 30 individuals (Dorper, DB and Hu sheep, HY) identified 15,108,1...
| Autores principales: | , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Taylor and Francis Group
2023
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/126522 |
| _version_ | 1855526404308860928 |
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| author | Lv, Xiaoyang Chen, Weihao Wang, Shanhe Cao, Xiukai Yuan, Zehu Getachew, Tesfaye Mwacharo, Joram Haile, Aynalem Sun, Wei |
| author_browse | Cao, Xiukai Chen, Weihao Getachew, Tesfaye Haile, Aynalem Lv, Xiaoyang Mwacharo, Joram Sun, Wei Wang, Shanhe Yuan, Zehu |
| author_facet | Lv, Xiaoyang Chen, Weihao Wang, Shanhe Cao, Xiukai Yuan, Zehu Getachew, Tesfaye Mwacharo, Joram Haile, Aynalem Sun, Wei |
| author_sort | Lv, Xiaoyang |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Dorper and Hu sheep exhibit different characteristics in terms of reproduction, growth, and meat quality. Comparison of the genomes of two breeds help to reveal important genomic information. In this study, whole genome resequencing of 30 individuals (Dorper, DB and Hu sheep, HY) identified 15,108,125 single nucleotide polymorphisms (SNPs). Population differentiation (Fst) and cross population extended haplotype homozygosity (XP-EHH) were performed for selective signal analysis. In total, 106 and 515 overlapped genes were present in both the Fst results and XP-EHH results in HY vs DB and in DB vs HY, respectively. In HY vs DB, 106 genes were enriched in 12 GO terms and 83 KEGG pathways, such as ATP binding (GO:0005524) and PI3K-Akt signaling pathway (oas04151). In DB vs HY, 515 genes were enriched in 109 GO terms and 215 KEGG pathways, such as skeletal muscle cell differentiation (GO:0035914) and MAPK signaling pathway (oas04010). According to the annotation results, we identified a series of candidate genes associated with reproduction (UNC5C, BMPR1B, and GLIS1), meat quality (MECOM, MEF2C, and MYF6), and immunity (GMDS, GALK1, and ITGB4). Our investigation has uncovered genomic information for important traits in sheep and provided a basis for subsequent studies of related traits. |
| format | Journal Article |
| id | CGSpace126522 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2023 |
| publishDateRange | 2023 |
| publishDateSort | 2023 |
| publisher | Taylor and Francis Group |
| publisherStr | Taylor and Francis Group |
| record_format | dspace |
| spelling | CGSpace1265222026-01-14T03:50:08Z Whole-genome resequencing of Dorper and Hu sheep to reveal selection signatures associated with important traits Lv, Xiaoyang Chen, Weihao Wang, Shanhe Cao, Xiukai Yuan, Zehu Getachew, Tesfaye Mwacharo, Joram Haile, Aynalem Sun, Wei sheep ovis aries goal 1 no poverty sheep poverty reduction, livelihoods and jobs selective signal analysis population differentiation cross population extended haplotype homozygosity Dorper and Hu sheep exhibit different characteristics in terms of reproduction, growth, and meat quality. Comparison of the genomes of two breeds help to reveal important genomic information. In this study, whole genome resequencing of 30 individuals (Dorper, DB and Hu sheep, HY) identified 15,108,125 single nucleotide polymorphisms (SNPs). Population differentiation (Fst) and cross population extended haplotype homozygosity (XP-EHH) were performed for selective signal analysis. In total, 106 and 515 overlapped genes were present in both the Fst results and XP-EHH results in HY vs DB and in DB vs HY, respectively. In HY vs DB, 106 genes were enriched in 12 GO terms and 83 KEGG pathways, such as ATP binding (GO:0005524) and PI3K-Akt signaling pathway (oas04151). In DB vs HY, 515 genes were enriched in 109 GO terms and 215 KEGG pathways, such as skeletal muscle cell differentiation (GO:0035914) and MAPK signaling pathway (oas04010). According to the annotation results, we identified a series of candidate genes associated with reproduction (UNC5C, BMPR1B, and GLIS1), meat quality (MECOM, MEF2C, and MYF6), and immunity (GMDS, GALK1, and ITGB4). Our investigation has uncovered genomic information for important traits in sheep and provided a basis for subsequent studies of related traits. 2023-01-03T22:07:32Z 2023-01-03T22:07:32Z Journal Article https://hdl.handle.net/10568/126522 en Limited Access Taylor and Francis Group Xiaoyang Lv, Weihao Chen, Shanhe Wang, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Joram Mwacharo, Aynalem Haile, Wei Sun. (6/10/2022). Whole-genome resequencing of Dorper and Hu sheep to reveal selection signatures associated with important traits. Animal Biotechnology. |
| spellingShingle | sheep ovis aries goal 1 no poverty sheep poverty reduction, livelihoods and jobs selective signal analysis population differentiation cross population extended haplotype homozygosity Lv, Xiaoyang Chen, Weihao Wang, Shanhe Cao, Xiukai Yuan, Zehu Getachew, Tesfaye Mwacharo, Joram Haile, Aynalem Sun, Wei Whole-genome resequencing of Dorper and Hu sheep to reveal selection signatures associated with important traits |
| title | Whole-genome resequencing of Dorper and Hu sheep to reveal selection signatures associated with important traits |
| title_full | Whole-genome resequencing of Dorper and Hu sheep to reveal selection signatures associated with important traits |
| title_fullStr | Whole-genome resequencing of Dorper and Hu sheep to reveal selection signatures associated with important traits |
| title_full_unstemmed | Whole-genome resequencing of Dorper and Hu sheep to reveal selection signatures associated with important traits |
| title_short | Whole-genome resequencing of Dorper and Hu sheep to reveal selection signatures associated with important traits |
| title_sort | whole genome resequencing of dorper and hu sheep to reveal selection signatures associated with important traits |
| topic | sheep ovis aries goal 1 no poverty sheep poverty reduction, livelihoods and jobs selective signal analysis population differentiation cross population extended haplotype homozygosity |
| url | https://hdl.handle.net/10568/126522 |
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