Markhor-derived introgression of a genomic region encompassing PAPSS2 confers high-altitude adaptability in Tibetan goats
Understanding the genetic mechanism of how animals adapt to extreme conditions is fundamental to determine the relationship between molecular evolution and changing environments. Goat is one of the first domesticated species and has evolved rapidly to adapt to diverse environments, including harsh h...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Oxford University Press
2022
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/125537 |
| _version_ | 1855518650293813248 |
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| author | Chao Li Yujiang Wu Bingchun Chen Yudong Cai Kalds, P. Shiwei Zhou Jingchen Zhang Ping Zhou Shangqu Gan Ting Jia Tianchun Pu Langda Suo Yan Li Ke Zhang Lan Li Purevdorj, M. Xihong Wang Ming Li Yu Wang Yao Liu Shuhong Huang Sonstegard, T. Ming-Shan Wang Kemp, Stephen J. Pausch, H. Yulin Chen Han Jianlin Yu Jiang Xiaolong Wang |
| author_browse | Bingchun Chen Chao Li Han Jianlin Jingchen Zhang Kalds, P. Ke Zhang Kemp, Stephen J. Lan Li Langda Suo Ming Li Ming-Shan Wang Pausch, H. Ping Zhou Purevdorj, M. Shangqu Gan Shiwei Zhou Shuhong Huang Sonstegard, T. Tianchun Pu Ting Jia Xiaolong Wang Xihong Wang Yan Li Yao Liu Yu Jiang Yu Wang Yudong Cai Yujiang Wu Yulin Chen |
| author_facet | Chao Li Yujiang Wu Bingchun Chen Yudong Cai Kalds, P. Shiwei Zhou Jingchen Zhang Ping Zhou Shangqu Gan Ting Jia Tianchun Pu Langda Suo Yan Li Ke Zhang Lan Li Purevdorj, M. Xihong Wang Ming Li Yu Wang Yao Liu Shuhong Huang Sonstegard, T. Ming-Shan Wang Kemp, Stephen J. Pausch, H. Yulin Chen Han Jianlin Yu Jiang Xiaolong Wang |
| author_sort | Chao Li |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Understanding the genetic mechanism of how animals adapt to extreme conditions is fundamental to determine the relationship between molecular evolution and changing environments. Goat is one of the first domesticated species and has evolved rapidly to adapt to diverse environments, including harsh high-altitude conditions with low temperature and poor oxygen supply but strong ultraviolet radiation. Here, we analyzed 331 genomes of domestic goats and wild caprid species living at varying altitudes (high > 3000 m above sea level and low < 1200 m), along with a reference-guided chromosome-scale assembly (contig-N50: 90.4 Mb) of a female Tibetan goat genome based on PacBio HiFi long reads, to dissect the genetic determinants underlying their adaptation to harsh conditions on the Qinghai-Tibetan Plateau (QTP). Population genomic analyses combined with genome-wide association studies (GWAS) revealed a genomic region harboring the 3′-phosphoadenosine 5′-phosphosulfate synthase 2 (PAPSS2) gene showing strong association with high-altitude adaptability (PGWAS = 3.62 × 10−25) in Tibetan goats. Transcriptomic data from 13 tissues revealed that PAPSS2 was implicated in hypoxia-related pathways in Tibetan goats. We further verified potential functional role of PAPSS2 in response to hypoxia in PAPSS2-deficient cells. Introgression analyses suggested that the PAPSS2 haplotype conferring the high-altitude adaptability in Tibetan goats originated from a recent hybridization between goats and a wild caprid species, the markhor (Capra falconeri). In conclusion, our results uncover a hitherto unknown contribution of PAPSS2 to high-altitude adaptability in Tibetan goats on QTP, following interspecific introgression and natural selection. |
| format | Journal Article |
| id | CGSpace125537 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Oxford University Press |
| publisherStr | Oxford University Press |
| record_format | dspace |
| spelling | CGSpace1255372025-12-08T09:54:28Z Markhor-derived introgression of a genomic region encompassing PAPSS2 confers high-altitude adaptability in Tibetan goats Chao Li Yujiang Wu Bingchun Chen Yudong Cai Kalds, P. Shiwei Zhou Jingchen Zhang Ping Zhou Shangqu Gan Ting Jia Tianchun Pu Langda Suo Yan Li Ke Zhang Lan Li Purevdorj, M. Xihong Wang Ming Li Yu Wang Yao Liu Shuhong Huang Sonstegard, T. Ming-Shan Wang Kemp, Stephen J. Pausch, H. Yulin Chen Han Jianlin Yu Jiang Xiaolong Wang goats goat breeds animal breeding genetics small ruminants molecular biology Understanding the genetic mechanism of how animals adapt to extreme conditions is fundamental to determine the relationship between molecular evolution and changing environments. Goat is one of the first domesticated species and has evolved rapidly to adapt to diverse environments, including harsh high-altitude conditions with low temperature and poor oxygen supply but strong ultraviolet radiation. Here, we analyzed 331 genomes of domestic goats and wild caprid species living at varying altitudes (high > 3000 m above sea level and low < 1200 m), along with a reference-guided chromosome-scale assembly (contig-N50: 90.4 Mb) of a female Tibetan goat genome based on PacBio HiFi long reads, to dissect the genetic determinants underlying their adaptation to harsh conditions on the Qinghai-Tibetan Plateau (QTP). Population genomic analyses combined with genome-wide association studies (GWAS) revealed a genomic region harboring the 3′-phosphoadenosine 5′-phosphosulfate synthase 2 (PAPSS2) gene showing strong association with high-altitude adaptability (PGWAS = 3.62 × 10−25) in Tibetan goats. Transcriptomic data from 13 tissues revealed that PAPSS2 was implicated in hypoxia-related pathways in Tibetan goats. We further verified potential functional role of PAPSS2 in response to hypoxia in PAPSS2-deficient cells. Introgression analyses suggested that the PAPSS2 haplotype conferring the high-altitude adaptability in Tibetan goats originated from a recent hybridization between goats and a wild caprid species, the markhor (Capra falconeri). In conclusion, our results uncover a hitherto unknown contribution of PAPSS2 to high-altitude adaptability in Tibetan goats on QTP, following interspecific introgression and natural selection. 2022-12-05 2022-11-21T12:12:09Z 2022-11-21T12:12:09Z Journal Article https://hdl.handle.net/10568/125537 en Open Access Oxford University Press Chao Li, Yujiang Wu, Bingchun Chen, Yudong Cai, Jiazhong Guo, Leonard, A.S., Kalds, P., Shiwei Zhou, Jingchen Zhang, Ping Zhou, Shangqu Gan, Ting Jia, Tianchun Pu, Langda Suo, Yan Li, Ke Zhang, Lan Li, Purevdorj, M., Xihong Wang, Ming Li, Yu Wang, Yao Liu, Shuhong Huang, Sonstegard, T., Ming-Shan Wang, Kemp, S., Pausch, H., Yulin Chen, Jian-Lin Han, Yu Jiang and Xiaolong Wang. 2022. Markhor-derived introgression of a genomic region encompassing PAPSS2 confers high-altitude adaptability in Tibetan goats. Molecular Biology and Evolution msac253. |
| spellingShingle | goats goat breeds animal breeding genetics small ruminants molecular biology Chao Li Yujiang Wu Bingchun Chen Yudong Cai Kalds, P. Shiwei Zhou Jingchen Zhang Ping Zhou Shangqu Gan Ting Jia Tianchun Pu Langda Suo Yan Li Ke Zhang Lan Li Purevdorj, M. Xihong Wang Ming Li Yu Wang Yao Liu Shuhong Huang Sonstegard, T. Ming-Shan Wang Kemp, Stephen J. Pausch, H. Yulin Chen Han Jianlin Yu Jiang Xiaolong Wang Markhor-derived introgression of a genomic region encompassing PAPSS2 confers high-altitude adaptability in Tibetan goats |
| title | Markhor-derived introgression of a genomic region encompassing PAPSS2 confers high-altitude adaptability in Tibetan goats |
| title_full | Markhor-derived introgression of a genomic region encompassing PAPSS2 confers high-altitude adaptability in Tibetan goats |
| title_fullStr | Markhor-derived introgression of a genomic region encompassing PAPSS2 confers high-altitude adaptability in Tibetan goats |
| title_full_unstemmed | Markhor-derived introgression of a genomic region encompassing PAPSS2 confers high-altitude adaptability in Tibetan goats |
| title_short | Markhor-derived introgression of a genomic region encompassing PAPSS2 confers high-altitude adaptability in Tibetan goats |
| title_sort | markhor derived introgression of a genomic region encompassing papss2 confers high altitude adaptability in tibetan goats |
| topic | goats goat breeds animal breeding genetics small ruminants molecular biology |
| url | https://hdl.handle.net/10568/125537 |
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