Chromosome-level genome assembly of the Muscovy duck provides insight into fatty liver susceptibility
The Muscovy duck (Cairina moschata) is an economically important poultry species, which is susceptible to fatty liver. Thus, the Muscovy duck may serve as an excellent candidate animal model of non-alcoholic fatty liver disease. However, the mechanisms underlying fatty liver development in this spec...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Elsevier
2022
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/125431 |
| _version_ | 1855533321416605696 |
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| author | Xu, Ming-Min Gu, Li-Hong Lv, Wan-Yue Duan, Sheng-Chang Li, Lian-Wei Du, Yuan Lu, Li-Zhi Zeng, Tao Hou, Zhuo-Cheng Ma, Zhanshan Sam Chen, Wei Adeola, A.C. Han Jianlin Xu, Tie-Shan Dong, Yang Zhang, Ya-Ping Peng, Min-Sheng |
| author_browse | Adeola, A.C. Chen, Wei Dong, Yang Du, Yuan Duan, Sheng-Chang Gu, Li-Hong Han Jianlin Hou, Zhuo-Cheng Li, Lian-Wei Lu, Li-Zhi Lv, Wan-Yue Ma, Zhanshan Sam Peng, Min-Sheng Xu, Ming-Min Xu, Tie-Shan Zeng, Tao Zhang, Ya-Ping |
| author_facet | Xu, Ming-Min Gu, Li-Hong Lv, Wan-Yue Duan, Sheng-Chang Li, Lian-Wei Du, Yuan Lu, Li-Zhi Zeng, Tao Hou, Zhuo-Cheng Ma, Zhanshan Sam Chen, Wei Adeola, A.C. Han Jianlin Xu, Tie-Shan Dong, Yang Zhang, Ya-Ping Peng, Min-Sheng |
| author_sort | Xu, Ming-Min |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | The Muscovy duck (Cairina moschata) is an economically important poultry species, which is susceptible to fatty liver. Thus, the Muscovy duck may serve as an excellent candidate animal model of non-alcoholic fatty liver disease. However, the mechanisms underlying fatty liver development in this species are poorly understood. In this study, we report a chromosome-level genome assembly of the Muscovy duck, with a contig N50 of 11.8 Mb and scaffold N50 of 83.16 Mb. The susceptibility of Muscovy duck to fatty liver was mainly attributed to weak lipid catabolism capabilities (fatty acid β-oxidation and lipolysis). Furthermore, conserved noncoding elements (CNEs) showing accelerated evolution contributed to fatty liver formation by down-regulating the expression of genes involved in hepatic lipid catabolism. We propose that the susceptibility of Muscovy duck to fatty liver is an evolutionary by-product. In conclusion, this study revealed the potential mechanisms underlying the susceptibility of Muscovy duck to fatty liver. |
| format | Journal Article |
| id | CGSpace125431 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace1254312025-10-26T13:02:55Z Chromosome-level genome assembly of the Muscovy duck provides insight into fatty liver susceptibility Xu, Ming-Min Gu, Li-Hong Lv, Wan-Yue Duan, Sheng-Chang Li, Lian-Wei Du, Yuan Lu, Li-Zhi Zeng, Tao Hou, Zhuo-Cheng Ma, Zhanshan Sam Chen, Wei Adeola, A.C. Han Jianlin Xu, Tie-Shan Dong, Yang Zhang, Ya-Ping Peng, Min-Sheng genetics animal breeding duck breeds fatty liver muscovy ducks The Muscovy duck (Cairina moschata) is an economically important poultry species, which is susceptible to fatty liver. Thus, the Muscovy duck may serve as an excellent candidate animal model of non-alcoholic fatty liver disease. However, the mechanisms underlying fatty liver development in this species are poorly understood. In this study, we report a chromosome-level genome assembly of the Muscovy duck, with a contig N50 of 11.8 Mb and scaffold N50 of 83.16 Mb. The susceptibility of Muscovy duck to fatty liver was mainly attributed to weak lipid catabolism capabilities (fatty acid β-oxidation and lipolysis). Furthermore, conserved noncoding elements (CNEs) showing accelerated evolution contributed to fatty liver formation by down-regulating the expression of genes involved in hepatic lipid catabolism. We propose that the susceptibility of Muscovy duck to fatty liver is an evolutionary by-product. In conclusion, this study revealed the potential mechanisms underlying the susceptibility of Muscovy duck to fatty liver. 2022-11 2022-11-12T17:07:06Z 2022-11-12T17:07:06Z Journal Article https://hdl.handle.net/10568/125431 en Open Access Elsevier Xu, Ming-Min, Gu, Li-Hong, Lv, Wan-Yue, Duan, Sheng-Chang, Li, Lian-Wei, Du, Yuan, Lu, Li-Zhi, Zeng, Tao, Hou, Zhuo-Cheng, Ma, Zhanshan Sam, Chen, Wei, Adeola, A.C., Jian-Lin, Han, Xu, Tie-Shan, Dong, Yang, Zhang, Ya-Ping and Peng, Min-Sheng. 2022. Chromosome-level genome assembly of the Muscovy duck provides insight into fatty liver susceptibility. Genomics 114(6):110518. |
| spellingShingle | genetics animal breeding duck breeds fatty liver muscovy ducks Xu, Ming-Min Gu, Li-Hong Lv, Wan-Yue Duan, Sheng-Chang Li, Lian-Wei Du, Yuan Lu, Li-Zhi Zeng, Tao Hou, Zhuo-Cheng Ma, Zhanshan Sam Chen, Wei Adeola, A.C. Han Jianlin Xu, Tie-Shan Dong, Yang Zhang, Ya-Ping Peng, Min-Sheng Chromosome-level genome assembly of the Muscovy duck provides insight into fatty liver susceptibility |
| title | Chromosome-level genome assembly of the Muscovy duck provides insight into fatty liver susceptibility |
| title_full | Chromosome-level genome assembly of the Muscovy duck provides insight into fatty liver susceptibility |
| title_fullStr | Chromosome-level genome assembly of the Muscovy duck provides insight into fatty liver susceptibility |
| title_full_unstemmed | Chromosome-level genome assembly of the Muscovy duck provides insight into fatty liver susceptibility |
| title_short | Chromosome-level genome assembly of the Muscovy duck provides insight into fatty liver susceptibility |
| title_sort | chromosome level genome assembly of the muscovy duck provides insight into fatty liver susceptibility |
| topic | genetics animal breeding duck breeds fatty liver muscovy ducks |
| url | https://hdl.handle.net/10568/125431 |
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