Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle
Indigenous Sudanese cattle are mainly indicine/zebu (humped) type. They thrive in the harshest dryland environments characterised by high temperatures, long seasonal dry periods, nutritional shortages, and vector disease challenges. Here, we sequenced 60 indigenous Sudanese cattle from six indigenou...
| Autores principales: | , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/121000 |
| _version_ | 1855542324202831872 |
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| author | Tijjani, Abdulfatai Salim, Bashir Barbosa da Silva, Marcus V. Eltahir, Hamza A. Musa, Taha H. Marshall, Karen Hanotte, Olivier H. Musa, Hassan H. |
| author_browse | Barbosa da Silva, Marcus V. Eltahir, Hamza A. Hanotte, Olivier H. Marshall, Karen Musa, Hassan H. Musa, Taha H. Salim, Bashir Tijjani, Abdulfatai |
| author_facet | Tijjani, Abdulfatai Salim, Bashir Barbosa da Silva, Marcus V. Eltahir, Hamza A. Musa, Taha H. Marshall, Karen Hanotte, Olivier H. Musa, Hassan H. |
| author_sort | Tijjani, Abdulfatai |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Indigenous Sudanese cattle are mainly indicine/zebu (humped) type. They thrive in the harshest dryland environments characterised by high temperatures, long seasonal dry periods, nutritional shortages, and vector disease challenges. Here, we sequenced 60 indigenous Sudanese cattle from six indigenous breeds and analysed the data using three genomic scan approaches to unravel cattle adaptation to the African dryland region. We identified a set of gene-rich selective sweep regions, detected mostly on chromosomes 5, 7 and 19, shared across African and Gir zebu. These include genes involved in immune response, body size and conformation, and heat stress response. We also identified selective sweep regions unique to Sudanese zebu. Of these, a 250 kb selective sweep on chromosome 16 spans seven genes, including PLCH2, PEX10, PRKCZ, and SKI, which are involved in alternative adaptive metabolic strategies of insulin signalling, glucose homeostasis, and fat metabolism. Our results suggest that environmental adaptation may involve recent and ancient selection at gene-rich regions, which might be under a common regulatory genetic control, in zebu cattle. |
| format | Journal Article |
| id | CGSpace121000 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace1210002025-10-26T13:01:22Z Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle Tijjani, Abdulfatai Salim, Bashir Barbosa da Silva, Marcus V. Eltahir, Hamza A. Musa, Taha H. Marshall, Karen Hanotte, Olivier H. Musa, Hassan H. animal breeding genomics genomes cattle zebu Indigenous Sudanese cattle are mainly indicine/zebu (humped) type. They thrive in the harshest dryland environments characterised by high temperatures, long seasonal dry periods, nutritional shortages, and vector disease challenges. Here, we sequenced 60 indigenous Sudanese cattle from six indigenous breeds and analysed the data using three genomic scan approaches to unravel cattle adaptation to the African dryland region. We identified a set of gene-rich selective sweep regions, detected mostly on chromosomes 5, 7 and 19, shared across African and Gir zebu. These include genes involved in immune response, body size and conformation, and heat stress response. We also identified selective sweep regions unique to Sudanese zebu. Of these, a 250 kb selective sweep on chromosome 16 spans seven genes, including PLCH2, PEX10, PRKCZ, and SKI, which are involved in alternative adaptive metabolic strategies of insulin signalling, glucose homeostasis, and fat metabolism. Our results suggest that environmental adaptation may involve recent and ancient selection at gene-rich regions, which might be under a common regulatory genetic control, in zebu cattle. 2022-07 2022-08-30T10:11:10Z 2022-08-30T10:11:10Z Journal Article https://hdl.handle.net/10568/121000 en Open Access Elsevier Tijjani, A., Salim, B., da Silva, M.V.B., Eltahir, H.A., Musa, T.H., Marshall, K., Hanotte, O., Musa, H.H. 2022. Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle. Genomics 114(4):110423. |
| spellingShingle | animal breeding genomics genomes cattle zebu Tijjani, Abdulfatai Salim, Bashir Barbosa da Silva, Marcus V. Eltahir, Hamza A. Musa, Taha H. Marshall, Karen Hanotte, Olivier H. Musa, Hassan H. Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle |
| title | Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle |
| title_full | Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle |
| title_fullStr | Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle |
| title_full_unstemmed | Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle |
| title_short | Genomic signatures for drylands adaptation at gene-rich regions in African zebu cattle |
| title_sort | genomic signatures for drylands adaptation at gene rich regions in african zebu cattle |
| topic | animal breeding genomics genomes cattle zebu |
| url | https://hdl.handle.net/10568/121000 |
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