Outbreaks of foot-and-mouth disease in Burundi, East Africa, in 2016, caused by different serotypes
Burundi is a small, densely populated country in the African Great Lakes region. In March 2016, several hundreds of cattle were reported with vesicular lesions, suggesting foot-and-mouth disease (FMD). Epithelial samples, saliva, and blood were collected in six of the affected provinces spread over...
| Autores principales: | , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
MDPI
2022
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| Acceso en línea: | https://hdl.handle.net/10568/119850 |
| _version_ | 1855513836173393920 |
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| author | Estevez Garcia, A.I. Lefebvre, D.J. Nyabongo, Lionel Haegeman, A. Nkundwanayo, C. Vleeschauwer, A. de Ntakirutimana, D. Leeuw, I. de Nsanganiyumwami, D. Niyokwizera, P. Berg, T. van den Niyokwishimira, A. Clercq, K.D. |
| author_browse | Berg, T. van den Clercq, K.D. Estevez Garcia, A.I. Haegeman, A. Leeuw, I. de Lefebvre, D.J. Niyokwishimira, A. Niyokwizera, P. Nkundwanayo, C. Nsanganiyumwami, D. Ntakirutimana, D. Nyabongo, Lionel Vleeschauwer, A. de |
| author_facet | Estevez Garcia, A.I. Lefebvre, D.J. Nyabongo, Lionel Haegeman, A. Nkundwanayo, C. Vleeschauwer, A. de Ntakirutimana, D. Leeuw, I. de Nsanganiyumwami, D. Niyokwizera, P. Berg, T. van den Niyokwishimira, A. Clercq, K.D. |
| author_sort | Estevez Garcia, A.I. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Burundi is a small, densely populated country in the African Great Lakes region. In March 2016, several hundreds of cattle were reported with vesicular lesions, suggesting foot-and-mouth disease (FMD). Epithelial samples, saliva, and blood were collected in six of the affected provinces spread over the country. The overall seroprevalence of FMD virus (FMDV) in the affected herds, as determined by antibodies against FMDV non-structural proteins, was estimated at 87%. Antibodies against FMDV serotypes O (52%), A (44%), C (19%), SAT1 (36%), SAT2 (58%), and SAT3 (23%) were detected across the provinces. FMDV genome was detected in samples from five of the six provinces using rRT-PCR. FMDV was isolated from samples from three provinces: in Cibitoke province, serotypes A and SAT2 were isolated, while in Mwaro and Rutana provinces, only serotype SAT2 was isolated. In Bururi and Cankuzo provinces, the serological profile suggested a recent incursion with serotype SAT2, while in Bubanza province, the serological profile suggested past incursions with serotype O and possibly serotype SAT1. The phylogenetic assessments showed the presence of topotypes A/Africa/G-I and SAT2/IV, similarly to previously characterized virus strains from other countries in the region, suggesting a transboundary origin and necessitating a regional approach for vaccination and control of FMD. |
| format | Journal Article |
| id | CGSpace119850 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | MDPI |
| publisherStr | MDPI |
| record_format | dspace |
| spelling | CGSpace1198502025-12-08T10:29:22Z Outbreaks of foot-and-mouth disease in Burundi, East Africa, in 2016, caused by different serotypes Estevez Garcia, A.I. Lefebvre, D.J. Nyabongo, Lionel Haegeman, A. Nkundwanayo, C. Vleeschauwer, A. de Ntakirutimana, D. Leeuw, I. de Nsanganiyumwami, D. Niyokwizera, P. Berg, T. van den Niyokwishimira, A. Clercq, K.D. epidemiology foot-and-mouth disease animal diseases disease control vaccines virology infectious diseases Burundi is a small, densely populated country in the African Great Lakes region. In March 2016, several hundreds of cattle were reported with vesicular lesions, suggesting foot-and-mouth disease (FMD). Epithelial samples, saliva, and blood were collected in six of the affected provinces spread over the country. The overall seroprevalence of FMD virus (FMDV) in the affected herds, as determined by antibodies against FMDV non-structural proteins, was estimated at 87%. Antibodies against FMDV serotypes O (52%), A (44%), C (19%), SAT1 (36%), SAT2 (58%), and SAT3 (23%) were detected across the provinces. FMDV genome was detected in samples from five of the six provinces using rRT-PCR. FMDV was isolated from samples from three provinces: in Cibitoke province, serotypes A and SAT2 were isolated, while in Mwaro and Rutana provinces, only serotype SAT2 was isolated. In Bururi and Cankuzo provinces, the serological profile suggested a recent incursion with serotype SAT2, while in Bubanza province, the serological profile suggested past incursions with serotype O and possibly serotype SAT1. The phylogenetic assessments showed the presence of topotypes A/Africa/G-I and SAT2/IV, similarly to previously characterized virus strains from other countries in the region, suggesting a transboundary origin and necessitating a regional approach for vaccination and control of FMD. 2022-05-30 2022-06-15T14:09:22Z 2022-06-15T14:09:22Z Journal Article https://hdl.handle.net/10568/119850 en Open Access MDPI Estevez Garcia, A.I., Lefebvre, D.J., Nyabongo, L., Haegeman, A., Nkundwanayo, C., De Vleeschauwer, A., Ntakirutimana, D., De Leeuw, I., Nsanganiyumwami, D., Niyokwizera, P., van den Berg, T., Niyokwishimira, A. and Clercq, K.D. 2022. Outbreaks of foot-and-mouth disease in Burundi, East Africa, in 2016, caused by different serotypes. Viruses 14:1077. |
| spellingShingle | epidemiology foot-and-mouth disease animal diseases disease control vaccines virology infectious diseases Estevez Garcia, A.I. Lefebvre, D.J. Nyabongo, Lionel Haegeman, A. Nkundwanayo, C. Vleeschauwer, A. de Ntakirutimana, D. Leeuw, I. de Nsanganiyumwami, D. Niyokwizera, P. Berg, T. van den Niyokwishimira, A. Clercq, K.D. Outbreaks of foot-and-mouth disease in Burundi, East Africa, in 2016, caused by different serotypes |
| title | Outbreaks of foot-and-mouth disease in Burundi, East Africa, in 2016, caused by different serotypes |
| title_full | Outbreaks of foot-and-mouth disease in Burundi, East Africa, in 2016, caused by different serotypes |
| title_fullStr | Outbreaks of foot-and-mouth disease in Burundi, East Africa, in 2016, caused by different serotypes |
| title_full_unstemmed | Outbreaks of foot-and-mouth disease in Burundi, East Africa, in 2016, caused by different serotypes |
| title_short | Outbreaks of foot-and-mouth disease in Burundi, East Africa, in 2016, caused by different serotypes |
| title_sort | outbreaks of foot and mouth disease in burundi east africa in 2016 caused by different serotypes |
| topic | epidemiology foot-and-mouth disease animal diseases disease control vaccines virology infectious diseases |
| url | https://hdl.handle.net/10568/119850 |
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