A locus conferring tolerance to Theileria infection in African cattle
East Coast fever, a tick-borne cattle disease caused by the Theileria parva parasite, is among the biggest natural killers of cattle in East Africa, leading to over 1 million deaths annually. Here we report on the genetic analysis of a cohort of Bos indicus (Boran) cattle demonstrating heritable tol...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
2022
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/119413 |
| _version_ | 1855537236492156928 |
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| author | Wragg, D. Cook, Elizabeth A.J. Latré de Laté, Perle Sitt, Tatjana Hemmink, Johanneke D. Chepkwony, Maurine C. Njeru, Regina Poole, Elizabeth J. Powell, J. Paxton, E.A. Callaby, R. Talenti, A. Miyunga, Antoinette Ndambuki, Gideon M. Mwaura, Stephen Auty, H. Matika, O. Hassan, M. Marshall, Karen Connelley, T. Morrison, L.J. Bronsvoort, B.M. de C. Morrison, W.I. Toye, Philip G. Prendergast, J.G.D. |
| author_browse | Auty, H. Bronsvoort, B.M. de C. Callaby, R. Chepkwony, Maurine C. Connelley, T. Cook, Elizabeth A.J. Hassan, M. Hemmink, Johanneke D. Latré de Laté, Perle Marshall, Karen Matika, O. Miyunga, Antoinette Morrison, L.J. Morrison, W.I. Mwaura, Stephen Ndambuki, Gideon M. Njeru, Regina Paxton, E.A. Poole, Elizabeth J. Powell, J. Prendergast, J.G.D. Sitt, Tatjana Talenti, A. Toye, Philip G. Wragg, D. |
| author_facet | Wragg, D. Cook, Elizabeth A.J. Latré de Laté, Perle Sitt, Tatjana Hemmink, Johanneke D. Chepkwony, Maurine C. Njeru, Regina Poole, Elizabeth J. Powell, J. Paxton, E.A. Callaby, R. Talenti, A. Miyunga, Antoinette Ndambuki, Gideon M. Mwaura, Stephen Auty, H. Matika, O. Hassan, M. Marshall, Karen Connelley, T. Morrison, L.J. Bronsvoort, B.M. de C. Morrison, W.I. Toye, Philip G. Prendergast, J.G.D. |
| author_sort | Wragg, D. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | East Coast fever, a tick-borne cattle disease caused by the Theileria parva parasite, is among the biggest natural killers of cattle in East Africa, leading to over 1 million deaths annually. Here we report on the genetic analysis of a cohort of Bos indicus (Boran) cattle demonstrating heritable tolerance to infection with T. parva (h2 = 0.65, s.e. 0.57). Through a linkage analysis we identify a 6 Mb genomic region on bovine chromosome 15 that is significantly associated with survival outcome following T. parva exposure. Testing this locus in an independent cohort of animals replicates this association with survival following T. parva infection. A stop gained variant in a paralogue of the FAF1 gene in this region was found to be highly associated with survival across both related and unrelated animals, with only one of the 20 homozygote carriers (T/T) of this change succumbing to the disease in contrast to 44 out of 97 animals homozygote for the reference allele (C/C). Consequently, we present a genetic locus linked to tolerance of one of Africa’s most important cattle diseases, raising the promise of marker-assisted selection for cattle that are less susceptible to infection by T. parva. |
| format | Journal Article |
| id | CGSpace119413 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| record_format | dspace |
| spelling | CGSpace1194132025-10-26T12:55:29Z A locus conferring tolerance to Theileria infection in African cattle Wragg, D. Cook, Elizabeth A.J. Latré de Laté, Perle Sitt, Tatjana Hemmink, Johanneke D. Chepkwony, Maurine C. Njeru, Regina Poole, Elizabeth J. Powell, J. Paxton, E.A. Callaby, R. Talenti, A. Miyunga, Antoinette Ndambuki, Gideon M. Mwaura, Stephen Auty, H. Matika, O. Hassan, M. Marshall, Karen Connelley, T. Morrison, L.J. Bronsvoort, B.M. de C. Morrison, W.I. Toye, Philip G. Prendergast, J.G.D. east coast fever animal diseases disease control theileria parva cattle East Coast fever, a tick-borne cattle disease caused by the Theileria parva parasite, is among the biggest natural killers of cattle in East Africa, leading to over 1 million deaths annually. Here we report on the genetic analysis of a cohort of Bos indicus (Boran) cattle demonstrating heritable tolerance to infection with T. parva (h2 = 0.65, s.e. 0.57). Through a linkage analysis we identify a 6 Mb genomic region on bovine chromosome 15 that is significantly associated with survival outcome following T. parva exposure. Testing this locus in an independent cohort of animals replicates this association with survival following T. parva infection. A stop gained variant in a paralogue of the FAF1 gene in this region was found to be highly associated with survival across both related and unrelated animals, with only one of the 20 homozygote carriers (T/T) of this change succumbing to the disease in contrast to 44 out of 97 animals homozygote for the reference allele (C/C). Consequently, we present a genetic locus linked to tolerance of one of Africa’s most important cattle diseases, raising the promise of marker-assisted selection for cattle that are less susceptible to infection by T. parva. 2022-04-21 2022-04-28T12:59:49Z 2022-04-28T12:59:49Z Journal Article https://hdl.handle.net/10568/119413 en Open Access Wragg, D., Cook, E.A.J., Latre de Late, P., SittI, T., Hemmink, J.D., Chepkwony, M.C., Njeru, R., Poole, E.J., Powell, J., Paxton, E.A., Callaby, R., Talenti, A., Miyunga, A.A., Ndambuki, G., Mwaura, S., Auty, H., Matika, O., Hassan, M., Marshall, K., Connelley, T., Morrison, L.J., Bronsvoort, B.M. de C., Morrison, W.I., Toye, P.G. and Prendergast, J.G.D. 2022. A locus conferring tolerance to Theileria infection in African cattle. PLOS Genetics 18(4):e1010099. |
| spellingShingle | east coast fever animal diseases disease control theileria parva cattle Wragg, D. Cook, Elizabeth A.J. Latré de Laté, Perle Sitt, Tatjana Hemmink, Johanneke D. Chepkwony, Maurine C. Njeru, Regina Poole, Elizabeth J. Powell, J. Paxton, E.A. Callaby, R. Talenti, A. Miyunga, Antoinette Ndambuki, Gideon M. Mwaura, Stephen Auty, H. Matika, O. Hassan, M. Marshall, Karen Connelley, T. Morrison, L.J. Bronsvoort, B.M. de C. Morrison, W.I. Toye, Philip G. Prendergast, J.G.D. A locus conferring tolerance to Theileria infection in African cattle |
| title | A locus conferring tolerance to Theileria infection in African cattle |
| title_full | A locus conferring tolerance to Theileria infection in African cattle |
| title_fullStr | A locus conferring tolerance to Theileria infection in African cattle |
| title_full_unstemmed | A locus conferring tolerance to Theileria infection in African cattle |
| title_short | A locus conferring tolerance to Theileria infection in African cattle |
| title_sort | locus conferring tolerance to theileria infection in african cattle |
| topic | east coast fever animal diseases disease control theileria parva cattle |
| url | https://hdl.handle.net/10568/119413 |
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