Identification and distribution of pathogens coinfecting with Brucella spp., Coxiella burnetii and Rift Valley fever virus in humans, livestock and wildlife
Zoonotic diseases, such as brucellosis, Q fever and Rift Valley fever (RVF) caused by Brucella spp., Coxiella burnetii and RVF virus, respectively, can have devastating effects on human, livestock, and wildlife health and cause economic hardship due to morbidity and mortality in livestock. Coinfecti...
| Autores principales: | , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Wiley
2022
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/117536 |
| _version_ | 1855534524740403200 |
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| author | Middlebrook, E.A. Romero, A.T. Bett, Bernard K. Nthiwa, Daniel Oyola, Samuel O. Fair, J.M. Bartlow, A.W. |
| author_browse | Bartlow, A.W. Bett, Bernard K. Fair, J.M. Middlebrook, E.A. Nthiwa, Daniel Oyola, Samuel O. Romero, A.T. |
| author_facet | Middlebrook, E.A. Romero, A.T. Bett, Bernard K. Nthiwa, Daniel Oyola, Samuel O. Fair, J.M. Bartlow, A.W. |
| author_sort | Middlebrook, E.A. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Zoonotic diseases, such as brucellosis, Q fever and Rift Valley fever (RVF) caused by Brucella spp., Coxiella burnetii and RVF virus, respectively, can have devastating effects on human, livestock, and wildlife health and cause economic hardship due to morbidity and mortality in livestock. Coinfection with multiple pathogens can lead to more severe disease outcomes and altered transmission dynamics. These three pathogens can alter host immune responses likely leading to increased morbidity, mortality and pathogen transmission during coinfection. Developing countries, such as those commonly afflicted by outbreaks of brucellosis, Q fever and RVF, have high disease burden and thus common coinfections. A literature survey provided information on case reports and studies investigating coinfections involving the three focal diseases. Fifty five studies were collected demonstrating coinfections of Brucella spp., C. burnetii or RVFV with 50 different pathogens, of which 64% were zoonotic. While the literature search criteria involved 'coinfection', only 24/55 studies showed coinfections with direct pathogen detection methods (microbiology, PCR and antigen test), while the rest only reported detection of antibodies against multiple pathogens, which only indicate a history of co-exposure, not concurrent infection. These studies lack the ability to test whether coinfection leads to changes in morbidity, mortality or transmission dynamics. We describe considerations and methods for identifying ongoing coinfections to address this critical blind spot in disease risk management. |
| format | Journal Article |
| id | CGSpace117536 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2022 |
| publishDateRange | 2022 |
| publishDateSort | 2022 |
| publisher | Wiley |
| publisherStr | Wiley |
| record_format | dspace |
| spelling | CGSpace1175362025-11-12T04:29:40Z Identification and distribution of pathogens coinfecting with Brucella spp., Coxiella burnetii and Rift Valley fever virus in humans, livestock and wildlife Middlebrook, E.A. Romero, A.T. Bett, Bernard K. Nthiwa, Daniel Oyola, Samuel O. Fair, J.M. Bartlow, A.W. zoonoses livestock wildlife brucellosis rift valley fever q fever Zoonotic diseases, such as brucellosis, Q fever and Rift Valley fever (RVF) caused by Brucella spp., Coxiella burnetii and RVF virus, respectively, can have devastating effects on human, livestock, and wildlife health and cause economic hardship due to morbidity and mortality in livestock. Coinfection with multiple pathogens can lead to more severe disease outcomes and altered transmission dynamics. These three pathogens can alter host immune responses likely leading to increased morbidity, mortality and pathogen transmission during coinfection. Developing countries, such as those commonly afflicted by outbreaks of brucellosis, Q fever and RVF, have high disease burden and thus common coinfections. A literature survey provided information on case reports and studies investigating coinfections involving the three focal diseases. Fifty five studies were collected demonstrating coinfections of Brucella spp., C. burnetii or RVFV with 50 different pathogens, of which 64% were zoonotic. While the literature search criteria involved 'coinfection', only 24/55 studies showed coinfections with direct pathogen detection methods (microbiology, PCR and antigen test), while the rest only reported detection of antibodies against multiple pathogens, which only indicate a history of co-exposure, not concurrent infection. These studies lack the ability to test whether coinfection leads to changes in morbidity, mortality or transmission dynamics. We describe considerations and methods for identifying ongoing coinfections to address this critical blind spot in disease risk management. 2022-05 2022-01-17T14:52:33Z 2022-01-17T14:52:33Z Journal Article https://hdl.handle.net/10568/117536 en Open Access application/pdf Wiley Middlebrook, E.A., Romero, A.T., Bett, B., Nthiwa, D., Oyola, S.O., Fair, J.M. and Bartlow, A.W. 2022. Identification and distribution of pathogens coinfecting with Brucella spp., Coxiella burnetii and Rift Valley fever virus in humans, livestock and wildlife. Zoonoses and Public Health 69(3): 175–194. |
| spellingShingle | zoonoses livestock wildlife brucellosis rift valley fever q fever Middlebrook, E.A. Romero, A.T. Bett, Bernard K. Nthiwa, Daniel Oyola, Samuel O. Fair, J.M. Bartlow, A.W. Identification and distribution of pathogens coinfecting with Brucella spp., Coxiella burnetii and Rift Valley fever virus in humans, livestock and wildlife |
| title | Identification and distribution of pathogens coinfecting with Brucella spp., Coxiella burnetii and Rift Valley fever virus in humans, livestock and wildlife |
| title_full | Identification and distribution of pathogens coinfecting with Brucella spp., Coxiella burnetii and Rift Valley fever virus in humans, livestock and wildlife |
| title_fullStr | Identification and distribution of pathogens coinfecting with Brucella spp., Coxiella burnetii and Rift Valley fever virus in humans, livestock and wildlife |
| title_full_unstemmed | Identification and distribution of pathogens coinfecting with Brucella spp., Coxiella burnetii and Rift Valley fever virus in humans, livestock and wildlife |
| title_short | Identification and distribution of pathogens coinfecting with Brucella spp., Coxiella burnetii and Rift Valley fever virus in humans, livestock and wildlife |
| title_sort | identification and distribution of pathogens coinfecting with brucella spp coxiella burnetii and rift valley fever virus in humans livestock and wildlife |
| topic | zoonoses livestock wildlife brucellosis rift valley fever q fever |
| url | https://hdl.handle.net/10568/117536 |
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