Genetic susceptibility to infectious disease in East African Shorthorn Zebu: A genome-wide analysis of the effect of heterozygosity and exotic introgression
Positive multi-locus heterozygosity-fitness correlations have been observed in a number of natural populations. They have been explained by the correlation between heterozygosity and inbreeding, and the negative effect of inbreeding on fitness (inbreeding depression). Exotic introgression in a local...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Springer
2013
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/116126 |
| _version_ | 1855520376946163712 |
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| author | Murray, Gemma G.R. Woolhouse, Mark E.J. Tapio, Miika Mbole-Kariuki, Mary N. Sonstegard, Tad S. Thumbi, Samuel M. Jennings, Amy E. Wyk, Ilana Conradie van Chase-Topping, Margo Kiara, Henry K. Toye, Philip G. Coetzer, Koos Bronsvoort, Barend M. de C. Hanotte, Olivier H. |
| author_browse | Bronsvoort, Barend M. de C. Chase-Topping, Margo Coetzer, Koos Hanotte, Olivier H. Jennings, Amy E. Kiara, Henry K. Mbole-Kariuki, Mary N. Murray, Gemma G.R. Sonstegard, Tad S. Tapio, Miika Thumbi, Samuel M. Toye, Philip G. Woolhouse, Mark E.J. Wyk, Ilana Conradie van |
| author_facet | Murray, Gemma G.R. Woolhouse, Mark E.J. Tapio, Miika Mbole-Kariuki, Mary N. Sonstegard, Tad S. Thumbi, Samuel M. Jennings, Amy E. Wyk, Ilana Conradie van Chase-Topping, Margo Kiara, Henry K. Toye, Philip G. Coetzer, Koos Bronsvoort, Barend M. de C. Hanotte, Olivier H. |
| author_sort | Murray, Gemma G.R. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Positive multi-locus heterozygosity-fitness correlations have been observed in a number of natural populations. They have been explained by the correlation between heterozygosity and inbreeding, and the negative effect of inbreeding on fitness (inbreeding depression). Exotic introgression in a locally adapted population has also been found to reduce fitness (outbreeding depression) through the breaking-up of co-adapted genes, or the introduction of non-locally adapted gene variants. In this study we examined the inter-relationships between genome-wide heterozygosity, introgression, and death or illness as a result of infectious disease in a sample of calves from an indigenous population of East African Shorthorn Zebu (crossbred Bos taurus x Bos indicus) in western Kenya. These calves were observed from birth to one year of age as part of the Infectious Disease in East African Livestock (IDEAL) project. Some of the calves were found to be genetic hybrids, resulting from the recent introgression of European cattle breed(s) into the indigenous population. European cattle are known to be less well adapted to the infectious diseases present in East Africa. If death and illness as a result of infectious disease have a genetic basis within the population, we would expect both a negative association of these outcomes with introgression and a positive association with heterozygosity. In this indigenous livestock population we observed negative associations between heterozygosity and both death and illness as a result of infectious disease and a positive association between European taurine introgression and episodes of clinical illness. We observe the effects of both inbreeding and outbreeding depression in the East African Shorthorn Zebu, and therefore find evidence of a genetic component to vulnerability to infectious disease. These results indicate that the significant burden of infectious disease in this population could, in principle, be reduced by altered breeding practices. |
| format | Journal Article |
| id | CGSpace116126 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2013 |
| publishDateRange | 2013 |
| publishDateSort | 2013 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace1161262024-10-03T07:40:51Z Genetic susceptibility to infectious disease in East African Shorthorn Zebu: A genome-wide analysis of the effect of heterozygosity and exotic introgression Murray, Gemma G.R. Woolhouse, Mark E.J. Tapio, Miika Mbole-Kariuki, Mary N. Sonstegard, Tad S. Thumbi, Samuel M. Jennings, Amy E. Wyk, Ilana Conradie van Chase-Topping, Margo Kiara, Henry K. Toye, Philip G. Coetzer, Koos Bronsvoort, Barend M. de C. Hanotte, Olivier H. animal diseases genomes genetics zebu infectious diseases animal breeding Positive multi-locus heterozygosity-fitness correlations have been observed in a number of natural populations. They have been explained by the correlation between heterozygosity and inbreeding, and the negative effect of inbreeding on fitness (inbreeding depression). Exotic introgression in a locally adapted population has also been found to reduce fitness (outbreeding depression) through the breaking-up of co-adapted genes, or the introduction of non-locally adapted gene variants. In this study we examined the inter-relationships between genome-wide heterozygosity, introgression, and death or illness as a result of infectious disease in a sample of calves from an indigenous population of East African Shorthorn Zebu (crossbred Bos taurus x Bos indicus) in western Kenya. These calves were observed from birth to one year of age as part of the Infectious Disease in East African Livestock (IDEAL) project. Some of the calves were found to be genetic hybrids, resulting from the recent introgression of European cattle breed(s) into the indigenous population. European cattle are known to be less well adapted to the infectious diseases present in East Africa. If death and illness as a result of infectious disease have a genetic basis within the population, we would expect both a negative association of these outcomes with introgression and a positive association with heterozygosity. In this indigenous livestock population we observed negative associations between heterozygosity and both death and illness as a result of infectious disease and a positive association between European taurine introgression and episodes of clinical illness. We observe the effects of both inbreeding and outbreeding depression in the East African Shorthorn Zebu, and therefore find evidence of a genetic component to vulnerability to infectious disease. These results indicate that the significant burden of infectious disease in this population could, in principle, be reduced by altered breeding practices. 2013 2021-11-17T17:03:08Z 2021-11-17T17:03:08Z Journal Article https://hdl.handle.net/10568/116126 en Open Access Springer Murray, G.G.R., Woolhouse, M.E.J., Tapio, M., Mbole-Kariuki, M.N., Sonstegard, T.S., Thumbi, S.M., Jennings, A.E., van Wyk, I.C., Chase-Topping, M., Kiara, H., Toye, P., Coetzer, K., deC Bronsvoort, B.M. and Hanotte, O. 2013. Genetic susceptibility to infectious disease in East African Shorthorn Zebu: A genome-wide analysis of the effect of heterozygosity and exotic introgression. BMC Evolutionary Biology 13:246. |
| spellingShingle | animal diseases genomes genetics zebu infectious diseases animal breeding Murray, Gemma G.R. Woolhouse, Mark E.J. Tapio, Miika Mbole-Kariuki, Mary N. Sonstegard, Tad S. Thumbi, Samuel M. Jennings, Amy E. Wyk, Ilana Conradie van Chase-Topping, Margo Kiara, Henry K. Toye, Philip G. Coetzer, Koos Bronsvoort, Barend M. de C. Hanotte, Olivier H. Genetic susceptibility to infectious disease in East African Shorthorn Zebu: A genome-wide analysis of the effect of heterozygosity and exotic introgression |
| title | Genetic susceptibility to infectious disease in East African Shorthorn Zebu: A genome-wide analysis of the effect of heterozygosity and exotic introgression |
| title_full | Genetic susceptibility to infectious disease in East African Shorthorn Zebu: A genome-wide analysis of the effect of heterozygosity and exotic introgression |
| title_fullStr | Genetic susceptibility to infectious disease in East African Shorthorn Zebu: A genome-wide analysis of the effect of heterozygosity and exotic introgression |
| title_full_unstemmed | Genetic susceptibility to infectious disease in East African Shorthorn Zebu: A genome-wide analysis of the effect of heterozygosity and exotic introgression |
| title_short | Genetic susceptibility to infectious disease in East African Shorthorn Zebu: A genome-wide analysis of the effect of heterozygosity and exotic introgression |
| title_sort | genetic susceptibility to infectious disease in east african shorthorn zebu a genome wide analysis of the effect of heterozygosity and exotic introgression |
| topic | animal diseases genomes genetics zebu infectious diseases animal breeding |
| url | https://hdl.handle.net/10568/116126 |
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