Inherited tolerance in cattle to the apicomplexan protozoan Theileria parva is associated with decreased proliferation of parasite-infected lymphocytes
Theileria parva is the causative agent of East Coast fever and Corridor disease, which are fatal, economically important diseases of cattle in eastern, central and southern Africa. Improved methods of control of the diseases are urgently required. The parasite transforms host lymphocytes, resulting...
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Frontiers Media
2021
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| Acceso en línea: | https://hdl.handle.net/10568/116125 |
| _version_ | 1855530683360870400 |
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| author | Latré de Laté, Perle Cook, Elizabeth A.J. Wragg, David Poole, Elizabeth J. Ndambuki, Gideon M. Miyunga, Antoinette Chepkwony, Maurine C. Mwaura, Stephen Ndiwa, Nicholas N. Prettejohn, Giles Sitt, Tatjana Aardt, Richard van Morrison, W. Ivan Prendergast, James G.D. Toye, Philip G. |
| author_browse | Aardt, Richard van Chepkwony, Maurine C. Cook, Elizabeth A.J. Latré de Laté, Perle Miyunga, Antoinette Morrison, W. Ivan Mwaura, Stephen Ndambuki, Gideon M. Ndiwa, Nicholas N. Poole, Elizabeth J. Prendergast, James G.D. Prettejohn, Giles Sitt, Tatjana Toye, Philip G. Wragg, David |
| author_facet | Latré de Laté, Perle Cook, Elizabeth A.J. Wragg, David Poole, Elizabeth J. Ndambuki, Gideon M. Miyunga, Antoinette Chepkwony, Maurine C. Mwaura, Stephen Ndiwa, Nicholas N. Prettejohn, Giles Sitt, Tatjana Aardt, Richard van Morrison, W. Ivan Prendergast, James G.D. Toye, Philip G. |
| author_sort | Latré de Laté, Perle |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Theileria parva is the causative agent of East Coast fever and Corridor disease, which are fatal, economically important diseases of cattle in eastern, central and southern Africa. Improved methods of control of the diseases are urgently required. The parasite transforms host lymphocytes, resulting in a rapid, clonal expansion of infected cells. Resistance to the disease has long been reported in cattle from T. parva-endemic areas. We reveal here that first- and second-generation descendants of a single Bos indicus bull survived severe challenge with T. parva, (overall survival rate 57.3% compared to 8.7% for unrelated animals) in a series of five field studies. Tolerant cattle displayed a delayed and less severe parasitosis and febrile response than unrelated animals. The in vitro proliferation of cells from surviving cattle was much reduced compared to those from animals that succumbed to infection. Additionally, some pro-inflammatory cytokines such as IL1β, IL6, TNFα or TGFβ which are usually strongly expressed in susceptible animals and are known to regulate cell growth or motility, remain low in tolerant animals. This correlates with the reduced proliferation and less severe clinical reactions observed in tolerant cattle. The results show for the first time that the inherited tolerance to T. parva is associated with decreased proliferation of infected lymphocytes. The results are discussed in terms of whether the reduced proliferation is the result of a perturbation of the transformation mechanism induced in infected cells or is due to an innate immune response present in the tolerant cattle. |
| format | Journal Article |
| id | CGSpace116125 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media |
| publisherStr | Frontiers Media |
| record_format | dspace |
| spelling | CGSpace1161252024-05-01T08:18:13Z Inherited tolerance in cattle to the apicomplexan protozoan Theileria parva is associated with decreased proliferation of parasite-infected lymphocytes Latré de Laté, Perle Cook, Elizabeth A.J. Wragg, David Poole, Elizabeth J. Ndambuki, Gideon M. Miyunga, Antoinette Chepkwony, Maurine C. Mwaura, Stephen Ndiwa, Nicholas N. Prettejohn, Giles Sitt, Tatjana Aardt, Richard van Morrison, W. Ivan Prendergast, James G.D. Toye, Philip G. animal diseases disease control east coast fever theileria parva cattle Theileria parva is the causative agent of East Coast fever and Corridor disease, which are fatal, economically important diseases of cattle in eastern, central and southern Africa. Improved methods of control of the diseases are urgently required. The parasite transforms host lymphocytes, resulting in a rapid, clonal expansion of infected cells. Resistance to the disease has long been reported in cattle from T. parva-endemic areas. We reveal here that first- and second-generation descendants of a single Bos indicus bull survived severe challenge with T. parva, (overall survival rate 57.3% compared to 8.7% for unrelated animals) in a series of five field studies. Tolerant cattle displayed a delayed and less severe parasitosis and febrile response than unrelated animals. The in vitro proliferation of cells from surviving cattle was much reduced compared to those from animals that succumbed to infection. Additionally, some pro-inflammatory cytokines such as IL1β, IL6, TNFα or TGFβ which are usually strongly expressed in susceptible animals and are known to regulate cell growth or motility, remain low in tolerant animals. This correlates with the reduced proliferation and less severe clinical reactions observed in tolerant cattle. The results show for the first time that the inherited tolerance to T. parva is associated with decreased proliferation of infected lymphocytes. The results are discussed in terms of whether the reduced proliferation is the result of a perturbation of the transformation mechanism induced in infected cells or is due to an innate immune response present in the tolerant cattle. 2021-11-05 2021-11-17T17:02:30Z 2021-11-17T17:02:30Z Journal Article https://hdl.handle.net/10568/116125 en Open Access Frontiers Media Latre de Late, P., Cook, E.A.J., Wragg, D., Poole, E.J., Ndambuki, G., Miyunga, A.A., Chepkwony, M.C., Mwaura, S., Ndiwa, N., Prettejohn, G., Sitt, T., Van Aardt, R., Morrison, W.I., Prendergast, J. and Toye, P. 2021. Inherited tolerance in cattle to the apicomplexan protozoan Theileria parva is associated with decreased proliferation of parasite-infected lymphocytes. Frontiers in Cellular and Infection Microbiology 11:751671. |
| spellingShingle | animal diseases disease control east coast fever theileria parva cattle Latré de Laté, Perle Cook, Elizabeth A.J. Wragg, David Poole, Elizabeth J. Ndambuki, Gideon M. Miyunga, Antoinette Chepkwony, Maurine C. Mwaura, Stephen Ndiwa, Nicholas N. Prettejohn, Giles Sitt, Tatjana Aardt, Richard van Morrison, W. Ivan Prendergast, James G.D. Toye, Philip G. Inherited tolerance in cattle to the apicomplexan protozoan Theileria parva is associated with decreased proliferation of parasite-infected lymphocytes |
| title | Inherited tolerance in cattle to the apicomplexan protozoan Theileria parva is associated with decreased proliferation of parasite-infected lymphocytes |
| title_full | Inherited tolerance in cattle to the apicomplexan protozoan Theileria parva is associated with decreased proliferation of parasite-infected lymphocytes |
| title_fullStr | Inherited tolerance in cattle to the apicomplexan protozoan Theileria parva is associated with decreased proliferation of parasite-infected lymphocytes |
| title_full_unstemmed | Inherited tolerance in cattle to the apicomplexan protozoan Theileria parva is associated with decreased proliferation of parasite-infected lymphocytes |
| title_short | Inherited tolerance in cattle to the apicomplexan protozoan Theileria parva is associated with decreased proliferation of parasite-infected lymphocytes |
| title_sort | inherited tolerance in cattle to the apicomplexan protozoan theileria parva is associated with decreased proliferation of parasite infected lymphocytes |
| topic | animal diseases disease control east coast fever theileria parva cattle |
| url | https://hdl.handle.net/10568/116125 |
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