Clinical evaluation of corridor disease in Bos indicus (Boran) cattle naturally infected with buffalo-derived Theileria parva
Corridor disease (CD) is a fatal condition of cattle caused by buffalo-derived Theileria parva. Unlike the related condition, East Coast fever, which results from infection with cattle-derived T. parva, CD has not been extensively studied. We describe in detail the clinical and laboratory findings i...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Frontiers Media
2021
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/115722 |
| _version_ | 1855513616811294720 |
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| author | Cook, Elizabeth A.J. Sitt, Tatjana Poole, Elizabeth J. Ndambuki, Gideon M. Mwaura, Stephen Chepkwony, M.C. Latré de Laté, Perle Miyunga, Antoinette Aardt, Richard van Prettejohn, G. Wragg, D. Prendergast, J.G.D. Morrison, W.I. Toye, Philip G. |
| author_browse | Aardt, Richard van Chepkwony, M.C. Cook, Elizabeth A.J. Latré de Laté, Perle Miyunga, Antoinette Morrison, W.I. Mwaura, Stephen Ndambuki, Gideon M. Poole, Elizabeth J. Prendergast, J.G.D. Prettejohn, G. Sitt, Tatjana Toye, Philip G. Wragg, D. |
| author_facet | Cook, Elizabeth A.J. Sitt, Tatjana Poole, Elizabeth J. Ndambuki, Gideon M. Mwaura, Stephen Chepkwony, M.C. Latré de Laté, Perle Miyunga, Antoinette Aardt, Richard van Prettejohn, G. Wragg, D. Prendergast, J.G.D. Morrison, W.I. Toye, Philip G. |
| author_sort | Cook, Elizabeth A.J. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Corridor disease (CD) is a fatal condition of cattle caused by buffalo-derived Theileria parva. Unlike the related condition, East Coast fever, which results from infection with cattle-derived T. parva, CD has not been extensively studied. We describe in detail the clinical and laboratory findings in cattle naturally infected with buffalo-derived T. parva. Forty-six cattle were exposed to buffalo-derived T. parva under field conditions at the Ol Pejeta Conservancy, Kenya, between 2013 and 2018. The first signs of disease observed in all animals were nasal discharge (mean day of onset was 9 days post-exposure), enlarged lymph nodes (10 days post-exposure), and pyrexia (13.7 days post-exposure). Coughing and labored breathing were observed in more than 50% of animals (14 days post-exposure). Less commonly observed signs, corneal edema (22%) and diarrhea (11%), were observed later in the disease progression (19 days post-exposure). All infections were considered clinically severe, and 42 animals succumbed to infection. The mean time to death across all studies was 18.4 days. The mean time from onset of clinical signs to death was 9 days and from pyrexia to death was 4.8 days, indicating a relatively short duration of clinical illness. There were significant relationships between days to death and the days to first temperature (chi2 = 4.00, p = 0.046), and days to peak temperature (chi2 = 25.81, p = 0.001), animals with earlier onset pyrexia died sooner. These clinical indicators may be useful for assessing the severity of disease in the future. All infections were confirmed by the presence of macroschizonts in lymph node biopsies (mean time to parasitosis was 11 days). Piroplasms were detected in the blood of two animals (4%) and 20 (43%) animals seroconverted. In this study, we demonstrate the successful approach to an experimental field study for CD in cattle. We also describe the clinical progression of CD in naturally infected cattle, including the onset and severity of clinical signs and pathology. Laboratory diagnoses based on examination of blood samples are unreliable, and alternatives may not be available to cattle keepers. The rapid development of CD requires recognition of the clinical signs, which may be useful for early diagnosis of the disease and effective intervention for affected animals. |
| format | Journal Article |
| id | CGSpace115722 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media |
| publisherStr | Frontiers Media |
| record_format | dspace |
| spelling | CGSpace1157222024-03-06T10:16:43Z Clinical evaluation of corridor disease in Bos indicus (Boran) cattle naturally infected with buffalo-derived Theileria parva Cook, Elizabeth A.J. Sitt, Tatjana Poole, Elizabeth J. Ndambuki, Gideon M. Mwaura, Stephen Chepkwony, M.C. Latré de Laté, Perle Miyunga, Antoinette Aardt, Richard van Prettejohn, G. Wragg, D. Prendergast, J.G.D. Morrison, W.I. Toye, Philip G. animal diseases cattle disease control water buffaloes east coast fever Corridor disease (CD) is a fatal condition of cattle caused by buffalo-derived Theileria parva. Unlike the related condition, East Coast fever, which results from infection with cattle-derived T. parva, CD has not been extensively studied. We describe in detail the clinical and laboratory findings in cattle naturally infected with buffalo-derived T. parva. Forty-six cattle were exposed to buffalo-derived T. parva under field conditions at the Ol Pejeta Conservancy, Kenya, between 2013 and 2018. The first signs of disease observed in all animals were nasal discharge (mean day of onset was 9 days post-exposure), enlarged lymph nodes (10 days post-exposure), and pyrexia (13.7 days post-exposure). Coughing and labored breathing were observed in more than 50% of animals (14 days post-exposure). Less commonly observed signs, corneal edema (22%) and diarrhea (11%), were observed later in the disease progression (19 days post-exposure). All infections were considered clinically severe, and 42 animals succumbed to infection. The mean time to death across all studies was 18.4 days. The mean time from onset of clinical signs to death was 9 days and from pyrexia to death was 4.8 days, indicating a relatively short duration of clinical illness. There were significant relationships between days to death and the days to first temperature (chi2 = 4.00, p = 0.046), and days to peak temperature (chi2 = 25.81, p = 0.001), animals with earlier onset pyrexia died sooner. These clinical indicators may be useful for assessing the severity of disease in the future. All infections were confirmed by the presence of macroschizonts in lymph node biopsies (mean time to parasitosis was 11 days). Piroplasms were detected in the blood of two animals (4%) and 20 (43%) animals seroconverted. In this study, we demonstrate the successful approach to an experimental field study for CD in cattle. We also describe the clinical progression of CD in naturally infected cattle, including the onset and severity of clinical signs and pathology. Laboratory diagnoses based on examination of blood samples are unreliable, and alternatives may not be available to cattle keepers. The rapid development of CD requires recognition of the clinical signs, which may be useful for early diagnosis of the disease and effective intervention for affected animals. 2021-09-29 2021-10-28T08:57:59Z 2021-10-28T08:57:59Z Journal Article https://hdl.handle.net/10568/115722 en Open Access Frontiers Media Cook, E.A.J., Sitt, T., Poole, E.J., Ndambuki, G., Mwaura, S., Chepkwony, M.C., Latre de Late, P., Miyunga, A.A., van Aardt, R., Prettejohn, G., Wragg, D., Prendergast, J.G.D., Morrison, W.I. and Toye, P. 2021. Clinical evaluation of corridor disease in Bos indicus (Boran) cattle naturally infected with buffalo-derived Theileria parva. Frontiers in Veterinary Science 8:731238. |
| spellingShingle | animal diseases cattle disease control water buffaloes east coast fever Cook, Elizabeth A.J. Sitt, Tatjana Poole, Elizabeth J. Ndambuki, Gideon M. Mwaura, Stephen Chepkwony, M.C. Latré de Laté, Perle Miyunga, Antoinette Aardt, Richard van Prettejohn, G. Wragg, D. Prendergast, J.G.D. Morrison, W.I. Toye, Philip G. Clinical evaluation of corridor disease in Bos indicus (Boran) cattle naturally infected with buffalo-derived Theileria parva |
| title | Clinical evaluation of corridor disease in Bos indicus (Boran) cattle naturally infected with buffalo-derived Theileria parva |
| title_full | Clinical evaluation of corridor disease in Bos indicus (Boran) cattle naturally infected with buffalo-derived Theileria parva |
| title_fullStr | Clinical evaluation of corridor disease in Bos indicus (Boran) cattle naturally infected with buffalo-derived Theileria parva |
| title_full_unstemmed | Clinical evaluation of corridor disease in Bos indicus (Boran) cattle naturally infected with buffalo-derived Theileria parva |
| title_short | Clinical evaluation of corridor disease in Bos indicus (Boran) cattle naturally infected with buffalo-derived Theileria parva |
| title_sort | clinical evaluation of corridor disease in bos indicus boran cattle naturally infected with buffalo derived theileria parva |
| topic | animal diseases cattle disease control water buffaloes east coast fever |
| url | https://hdl.handle.net/10568/115722 |
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