Local ancestry to identify selection in response to trypanosome infection in Baoulé x Zebu crossbred cattle in Burkina Faso
The genomes of crossbred (admixed) individuals are a mosaic of ancestral haplotypes formed by recombination in each generation. The proportion of these ancestral haplotypes in certain genomic regions can be responsible for either susceptibility or tolerance against pathogens, and for performances in...
| Autores principales: | , , , , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Frontiers Media
2021
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/115590 |
| _version_ | 1855539828519600128 |
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| author | Yougbaré, B. Ouédraogo, D. Tapsoba, A.S.R. Soudré, A. Zoma, B.L. Orozco-terWengel, P. Moumouni, S. Ouédraogo-Koné, S. Wurzinger, Maria Tamboura, H.H. Traoré, A. Okeyo Mwai, Ally Sölkner, J. Khayatzadeh, N. Mészáros, Gábor Burger, P.A. |
| author_browse | Burger, P.A. Khayatzadeh, N. Moumouni, S. Mészáros, Gábor Okeyo Mwai, Ally Orozco-terWengel, P. Ouédraogo, D. Ouédraogo-Koné, S. Soudré, A. Sölkner, J. Tamboura, H.H. Tapsoba, A.S.R. Traoré, A. Wurzinger, Maria Yougbaré, B. Zoma, B.L. |
| author_facet | Yougbaré, B. Ouédraogo, D. Tapsoba, A.S.R. Soudré, A. Zoma, B.L. Orozco-terWengel, P. Moumouni, S. Ouédraogo-Koné, S. Wurzinger, Maria Tamboura, H.H. Traoré, A. Okeyo Mwai, Ally Sölkner, J. Khayatzadeh, N. Mészáros, Gábor Burger, P.A. |
| author_sort | Yougbaré, B. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | The genomes of crossbred (admixed) individuals are a mosaic of ancestral haplotypes formed by recombination in each generation. The proportion of these ancestral haplotypes in certain genomic regions can be responsible for either susceptibility or tolerance against pathogens, and for performances in production traits. Using a medium-density genomic marker panel from the Illumina Bovine SNP50 BeadChip, we estimated individual admixture proportions for Baoulé x Zebu crossbred cattle in Burkina Faso, which were tested for trypanosome infection by direct ELISA from blood samples. Furthermore, we calculated local ancestry deviation from average for each SNP across 29 autosomes to identify potential regions under selection in the trypanotolerant Baoulé cattle and their crossbreds. We identified significant deviation from the local average ancestry (above 5 and 10% genome-wide thresholds) on chromosomes 8 and 19 in the positive animals, while the negative ones showed higher deviation on chromosomes 6, 19, 21, and 22. Some candidate genes on chromosome 6 (PDGFRA) and chromosome 19 (CDC6) have been found associated to trypanotolerance in West African taurines. Screening for FST outliers in trypanosome positive/negative animals we detected seven variants putatively under selection. Finally, we identified a minimum set of highly ancestry informative markers for routine admixture testing. The results of this study contribute to a better understanding of the genetic basis of trypanotolerance in Baoulé cattle and their crossbreeds. Furthermore, we provide a small informative marker set to monitor admixture in this valuable indigenous breed. As such, our results are important for conserving the genetic uniqueness and trypanotolerance of Baoulé cattle, as well as for the improvement of Baoulé and Zebu crossbreds in specific community-based breeding programs. |
| format | Journal Article |
| id | CGSpace115590 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Frontiers Media |
| publisherStr | Frontiers Media |
| record_format | dspace |
| spelling | CGSpace1155902024-05-01T08:19:39Z Local ancestry to identify selection in response to trypanosome infection in Baoulé x Zebu crossbred cattle in Burkina Faso Yougbaré, B. Ouédraogo, D. Tapsoba, A.S.R. Soudré, A. Zoma, B.L. Orozco-terWengel, P. Moumouni, S. Ouédraogo-Koné, S. Wurzinger, Maria Tamboura, H.H. Traoré, A. Okeyo Mwai, Ally Sölkner, J. Khayatzadeh, N. Mészáros, Gábor Burger, P.A. cattle animal breeding livestock trypanosomiasis genetics indigenous breeds The genomes of crossbred (admixed) individuals are a mosaic of ancestral haplotypes formed by recombination in each generation. The proportion of these ancestral haplotypes in certain genomic regions can be responsible for either susceptibility or tolerance against pathogens, and for performances in production traits. Using a medium-density genomic marker panel from the Illumina Bovine SNP50 BeadChip, we estimated individual admixture proportions for Baoulé x Zebu crossbred cattle in Burkina Faso, which were tested for trypanosome infection by direct ELISA from blood samples. Furthermore, we calculated local ancestry deviation from average for each SNP across 29 autosomes to identify potential regions under selection in the trypanotolerant Baoulé cattle and their crossbreds. We identified significant deviation from the local average ancestry (above 5 and 10% genome-wide thresholds) on chromosomes 8 and 19 in the positive animals, while the negative ones showed higher deviation on chromosomes 6, 19, 21, and 22. Some candidate genes on chromosome 6 (PDGFRA) and chromosome 19 (CDC6) have been found associated to trypanotolerance in West African taurines. Screening for FST outliers in trypanosome positive/negative animals we detected seven variants putatively under selection. Finally, we identified a minimum set of highly ancestry informative markers for routine admixture testing. The results of this study contribute to a better understanding of the genetic basis of trypanotolerance in Baoulé cattle and their crossbreeds. Furthermore, we provide a small informative marker set to monitor admixture in this valuable indigenous breed. As such, our results are important for conserving the genetic uniqueness and trypanotolerance of Baoulé cattle, as well as for the improvement of Baoulé and Zebu crossbreds in specific community-based breeding programs. 2021-09-27 2021-10-21T09:25:45Z 2021-10-21T09:25:45Z Journal Article https://hdl.handle.net/10568/115590 en Open Access Frontiers Media Yougbaré, B., Ouédraogo, D., Tapsoba, A.S.R., Soudré, A., Zoma, B.L., Orozco-terWengel, P., Moumouni, S., Ouédraogo-Koné, S., Wurzinger, M., Tamboura, H.H., Traoré, A., Mwai, O.A., Sölkner, J., Khayatzadeh, N., Mészáros, G. and Burger, P.A. 2021. Local ancestry to identify selection in response to trypanosome infection in Baoulé x Zebu crossbred cattle in Burkina Faso. Frontiers in Genetics 12:670390. |
| spellingShingle | cattle animal breeding livestock trypanosomiasis genetics indigenous breeds Yougbaré, B. Ouédraogo, D. Tapsoba, A.S.R. Soudré, A. Zoma, B.L. Orozco-terWengel, P. Moumouni, S. Ouédraogo-Koné, S. Wurzinger, Maria Tamboura, H.H. Traoré, A. Okeyo Mwai, Ally Sölkner, J. Khayatzadeh, N. Mészáros, Gábor Burger, P.A. Local ancestry to identify selection in response to trypanosome infection in Baoulé x Zebu crossbred cattle in Burkina Faso |
| title | Local ancestry to identify selection in response to trypanosome infection in Baoulé x Zebu crossbred cattle in Burkina Faso |
| title_full | Local ancestry to identify selection in response to trypanosome infection in Baoulé x Zebu crossbred cattle in Burkina Faso |
| title_fullStr | Local ancestry to identify selection in response to trypanosome infection in Baoulé x Zebu crossbred cattle in Burkina Faso |
| title_full_unstemmed | Local ancestry to identify selection in response to trypanosome infection in Baoulé x Zebu crossbred cattle in Burkina Faso |
| title_short | Local ancestry to identify selection in response to trypanosome infection in Baoulé x Zebu crossbred cattle in Burkina Faso |
| title_sort | local ancestry to identify selection in response to trypanosome infection in baoule x zebu crossbred cattle in burkina faso |
| topic | cattle animal breeding livestock trypanosomiasis genetics indigenous breeds |
| url | https://hdl.handle.net/10568/115590 |
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