Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya
Camels are increasingly becoming the livestock of choice for pastoralists reeling from effects of climate change in semi-arid and arid parts of Kenya. As the population of camels rises, better understanding of their role in the epidemiology of zoonotic diseases in Kenya is a public health priority....
| Autores principales: | , , , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Public Library of Science
2021
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| Acceso en línea: | https://hdl.handle.net/10568/113148 |
| _version_ | 1855539448258756608 |
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| author | Muturi, M. Akoko, James M. Nthiwa, D. Chege, B. Nyamota, Richard Mutiiria, M. Maina, Josphat Thumbi, Samuel M. Nyamai, M. Kahariri, S. Sitawa, R. Kimutai, J. Kuria, W. Mwatondo, Athman Bett, Bernard K. |
| author_browse | Akoko, James M. Bett, Bernard K. Chege, B. Kahariri, S. Kimutai, J. Kuria, W. Maina, Josphat Mutiiria, M. Muturi, M. Mwatondo, Athman Nthiwa, D. Nyamai, M. Nyamota, Richard Sitawa, R. Thumbi, Samuel M. |
| author_facet | Muturi, M. Akoko, James M. Nthiwa, D. Chege, B. Nyamota, Richard Mutiiria, M. Maina, Josphat Thumbi, Samuel M. Nyamai, M. Kahariri, S. Sitawa, R. Kimutai, J. Kuria, W. Mwatondo, Athman Bett, Bernard K. |
| author_sort | Muturi, M. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Camels are increasingly becoming the livestock of choice for pastoralists reeling from effects of climate change in semi-arid and arid parts of Kenya. As the population of camels rises, better understanding of their role in the epidemiology of zoonotic diseases in Kenya is a public health priority. Rift Valley fever (RVF), brucellosis and Q fever are three of the top priority diseases in the country but the involvement of camels in the transmission dynamics of these diseases is poorly understood. We analyzed 120 camel serum samples from northern Kenya to establish seropositivity rates of the three pathogens and to characterize the infecting Brucella species using molecular assays. We found seropositivity of 24.2% (95% confidence interval [CI]: 16.5-31.8%) for Brucella, 20.8% (95% CI: 13.6-28.1%) and 14.2% (95% CI: 7.9-20.4%) for Coxiella burnetii and Rift valley fever virus respectively. We found 27.5% (95% CI: 19.5-35.5%) of the animals were seropositive for at least one pathogen and 13.3% (95% CI: 7.2-19.4%) were seropositive for at least two pathogens. B. melitensis was the only Brucella spp. detected. The high sero-positivity rates are indicative of the endemicity of these pathogens among camel populations and the possible role the species has in the epidemiology of zoonotic diseases. Considering the strong association between human infection and contact with livestock for most zoonotic infections in Kenya, there is immediate need to conduct further research to determine the role of camels in transmission of these zoonoses to other livestock species and humans. This information will be useful for designing more effective surveillance systems and intervention measures. |
| format | Journal Article |
| id | CGSpace113148 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Public Library of Science |
| publisherStr | Public Library of Science |
| record_format | dspace |
| spelling | CGSpace1131482025-08-15T13:22:54Z Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya Muturi, M. Akoko, James M. Nthiwa, D. Chege, B. Nyamota, Richard Mutiiria, M. Maina, Josphat Thumbi, Samuel M. Nyamai, M. Kahariri, S. Sitawa, R. Kimutai, J. Kuria, W. Mwatondo, Athman Bett, Bernard K. animal diseases zoonoses rift valley fever brucella coxiella burnetii camels livestock Camels are increasingly becoming the livestock of choice for pastoralists reeling from effects of climate change in semi-arid and arid parts of Kenya. As the population of camels rises, better understanding of their role in the epidemiology of zoonotic diseases in Kenya is a public health priority. Rift Valley fever (RVF), brucellosis and Q fever are three of the top priority diseases in the country but the involvement of camels in the transmission dynamics of these diseases is poorly understood. We analyzed 120 camel serum samples from northern Kenya to establish seropositivity rates of the three pathogens and to characterize the infecting Brucella species using molecular assays. We found seropositivity of 24.2% (95% confidence interval [CI]: 16.5-31.8%) for Brucella, 20.8% (95% CI: 13.6-28.1%) and 14.2% (95% CI: 7.9-20.4%) for Coxiella burnetii and Rift valley fever virus respectively. We found 27.5% (95% CI: 19.5-35.5%) of the animals were seropositive for at least one pathogen and 13.3% (95% CI: 7.2-19.4%) were seropositive for at least two pathogens. B. melitensis was the only Brucella spp. detected. The high sero-positivity rates are indicative of the endemicity of these pathogens among camel populations and the possible role the species has in the epidemiology of zoonotic diseases. Considering the strong association between human infection and contact with livestock for most zoonotic infections in Kenya, there is immediate need to conduct further research to determine the role of camels in transmission of these zoonoses to other livestock species and humans. This information will be useful for designing more effective surveillance systems and intervention measures. 2021-03-26 2021-03-28T18:48:59Z 2021-03-28T18:48:59Z Journal Article https://hdl.handle.net/10568/113148 en Open Access Public Library of Science Muturi, M., Akoko, J., Nthiwa, D., Chege, B., Nyamota, R., Mutiiria, M., Maina, J., Thumbi, S.M., Nyamai, M., Kahariri, S., Sitawa, R., Kimutai, J., Kuria, W., Mwatondo, A. and Bett, B. 2021. Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya. PLOS Neglected Tropical Diseases 15(3): e0009275. |
| spellingShingle | animal diseases zoonoses rift valley fever brucella coxiella burnetii camels livestock Muturi, M. Akoko, James M. Nthiwa, D. Chege, B. Nyamota, Richard Mutiiria, M. Maina, Josphat Thumbi, Samuel M. Nyamai, M. Kahariri, S. Sitawa, R. Kimutai, J. Kuria, W. Mwatondo, Athman Bett, Bernard K. Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya |
| title | Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya |
| title_full | Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya |
| title_fullStr | Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya |
| title_full_unstemmed | Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya |
| title_short | Serological evidence of single and mixed infections of Rift Valley fever virus, Brucella spp. and Coxiella burnetii in dromedary camels in Kenya |
| title_sort | serological evidence of single and mixed infections of rift valley fever virus brucella spp and coxiella burnetii in dromedary camels in kenya |
| topic | animal diseases zoonoses rift valley fever brucella coxiella burnetii camels livestock |
| url | https://hdl.handle.net/10568/113148 |
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