Control of pathogenesis in animal African trypanosomiasis: A search for answers at ILRAD, ILCA and ILRI, 1975-2018
This book chapter describes the management of animal trypanosomiasis: (i) vector control/eradication; (ii) use of trypanocides; and (iii) use of trypanotolerant breeds of cattle. Vector control includes reducing the tsetse fly population with traps and insecticides, and in areas with a high populati...
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| Format: | Book Chapter |
| Language: | Inglés |
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CAB International
2020
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| Online Access: | https://hdl.handle.net/10568/110744 |
| _version_ | 1855535576987467776 |
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| author | Black, Samuel J. |
| author_browse | Black, Samuel J. |
| author_facet | Black, Samuel J. |
| author_sort | Black, Samuel J. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | This book chapter describes the management of animal trypanosomiasis: (i) vector control/eradication; (ii) use of trypanocides; and (iii) use of trypanotolerant breeds of cattle. Vector control includes reducing the tsetse fly population with traps and insecticides, and in areas with a high population of trypanosome infected tsetse, animals are prophylactically administered antiparasitic drugs. To date, there is no AAT vaccine available, as discussed below. While disappointing with respect to AAT control, studies of AAT pathogenesis at ILRAD/ILRI did identify the definitive question for immunological research on AAT, namely, how do trypanosomes eliminate TD antibody responses in trypanosomiasis-susceptible mammals? In addition, the work at ILRI on the genetic basis of trypanotolerance contributed a high-density singlenucleotide polymorphism (SNP) map of the bovine genome that has intrinsic value for analysis of QTLs that control other traits, including susceptibility to other diseases. |
| format | Book Chapter |
| id | CGSpace110744 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | CAB International |
| publisherStr | CAB International |
| record_format | dspace |
| spelling | CGSpace1107442023-12-08T19:36:04Z Control of pathogenesis in animal African trypanosomiasis: A search for answers at ILRAD, ILCA and ILRI, 1975-2018 Black, Samuel J. livestock research trypanosomiasis This book chapter describes the management of animal trypanosomiasis: (i) vector control/eradication; (ii) use of trypanocides; and (iii) use of trypanotolerant breeds of cattle. Vector control includes reducing the tsetse fly population with traps and insecticides, and in areas with a high population of trypanosome infected tsetse, animals are prophylactically administered antiparasitic drugs. To date, there is no AAT vaccine available, as discussed below. While disappointing with respect to AAT control, studies of AAT pathogenesis at ILRAD/ILRI did identify the definitive question for immunological research on AAT, namely, how do trypanosomes eliminate TD antibody responses in trypanosomiasis-susceptible mammals? In addition, the work at ILRI on the genetic basis of trypanotolerance contributed a high-density singlenucleotide polymorphism (SNP) map of the bovine genome that has intrinsic value for analysis of QTLs that control other traits, including susceptibility to other diseases. 2020-01 2021-01-07T08:45:30Z 2021-01-07T08:45:30Z Book Chapter https://hdl.handle.net/10568/110744 en https://hdl.handle.net/10568/108972 Open Access application/pdf CAB International Black, S.J. 2020. Control of pathogenesis in animal African trypanosomiasis: A search for answers at ILRAD, ILCA and ILRI, 1975-2018. IN: McIntire, J. and Grace, D. (eds.). The impact of the International Livestock Research Institute. Nairobi, Kenya: ILRI and Wallingford, UK: CABI: 103-147 |
| spellingShingle | livestock research trypanosomiasis Black, Samuel J. Control of pathogenesis in animal African trypanosomiasis: A search for answers at ILRAD, ILCA and ILRI, 1975-2018 |
| title | Control of pathogenesis in animal African trypanosomiasis: A search for answers at ILRAD, ILCA and ILRI, 1975-2018 |
| title_full | Control of pathogenesis in animal African trypanosomiasis: A search for answers at ILRAD, ILCA and ILRI, 1975-2018 |
| title_fullStr | Control of pathogenesis in animal African trypanosomiasis: A search for answers at ILRAD, ILCA and ILRI, 1975-2018 |
| title_full_unstemmed | Control of pathogenesis in animal African trypanosomiasis: A search for answers at ILRAD, ILCA and ILRI, 1975-2018 |
| title_short | Control of pathogenesis in animal African trypanosomiasis: A search for answers at ILRAD, ILCA and ILRI, 1975-2018 |
| title_sort | control of pathogenesis in animal african trypanosomiasis a search for answers at ilrad ilca and ilri 1975 2018 |
| topic | livestock research trypanosomiasis |
| url | https://hdl.handle.net/10568/110744 |
| work_keys_str_mv | AT blacksamuelj controlofpathogenesisinanimalafricantrypanosomiasisasearchforanswersatilradilcaandilri19752018 |