Evolutionary relationship and population structure of domestic Bovidae animals based on MHC-linked and neutral autosomal microsatellite markers
Major histocompatibility complex (MHC) genes are critical for disease resistance or susceptibility responsible for host-pathogen interactions determined mainly by extensive polymorphisms in the MHC genes. Here, we examined the diversity and phylogenetic pattern of MHC haplotypes reconstructed using...
| Autores principales: | , , , , , , , , , , , , , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2020
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/110636 |
| _version_ | 1855531166954684416 |
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| author | Guang-Xin, E. Li-Peng Chen Dong-Ke Zhou Bai-Gao Yang Jia-Hua Zhang Yong-Ju Zhao Qiong-Hua Hong Yue-Hui Ma Ming-Xing Chu Lu-Pei Zhang Wang-Dui Basang Yan-Bin Zhu Yan-Guo Han Ri-Su Na Yan Zeng Zhong-Quan Zhao Yong-Fu Huang Han Jianlin |
| author_browse | Bai-Gao Yang Dong-Ke Zhou Guang-Xin, E. Han Jianlin Jia-Hua Zhang Li-Peng Chen Lu-Pei Zhang Ming-Xing Chu Qiong-Hua Hong Ri-Su Na Wang-Dui Basang Yan Zeng Yan-Bin Zhu Yan-Guo Han Yong-Fu Huang Yong-Ju Zhao Yue-Hui Ma Zhong-Quan Zhao |
| author_facet | Guang-Xin, E. Li-Peng Chen Dong-Ke Zhou Bai-Gao Yang Jia-Hua Zhang Yong-Ju Zhao Qiong-Hua Hong Yue-Hui Ma Ming-Xing Chu Lu-Pei Zhang Wang-Dui Basang Yan-Bin Zhu Yan-Guo Han Ri-Su Na Yan Zeng Zhong-Quan Zhao Yong-Fu Huang Han Jianlin |
| author_sort | Guang-Xin, E. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Major histocompatibility complex (MHC) genes are critical for disease resistance or susceptibility responsible for host-pathogen interactions determined mainly by extensive polymorphisms in the MHC genes. Here, we examined the diversity and phylogenetic pattern of MHC haplotypes reconstructed using three MHC-linked microsatellite markers in 55 populations of five Bovidae species and compared them with those based on neutral autosomal microsatellite markers (NAMs). Three-hundred-and-forty MHC haplotypes were identified in 1453 Bovidae individuals, suggesting significantly higher polymorphism and heterozygosity compared with those based on NAMs. The ambitious boundaries in population differentiation (phylogenetic network, pairwise FST and STRUCTURE analyses) within and between species assessed using the MHC haplotypes were different from those revealed by NAMs associated closely with speciation, geographical distribution, domestication and management histories. In addition, the mean FST was significantly correlated negatively with the number of observed alleles (NA), observed (HO) and expected (HE) heterozygosity and polymorphism information content (PIC) (P < 0.05) in the MHC haplotype dataset while there was no correction of the mean FST estimates (P> 0.05) between the MHC haplotype and NAMs datasets. Analysis of molecular variance (AMOVA) revealed a lower percentage of total variance (PTV) between species/groups based on the MHC-linked microsatellites than NAMs. Therefore, it was inferred that individuals within populations accumulated as many MHC variants as possible to increase their heterozygosity and thus the survival rate of their affiliated populations and species, which eventually reduced population differentiation and thereby complicated their classification and phylogenetic relationship inference. In summary, host-pathogen coevolution and heterozygote advantage, rather than demographic history, act as key driving forces shaping the MHC diversity within the populations and determining the interspecific MHC diversity. |
| format | Journal Article |
| id | CGSpace110636 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace1106362025-12-08T09:54:28Z Evolutionary relationship and population structure of domestic Bovidae animals based on MHC-linked and neutral autosomal microsatellite markers Guang-Xin, E. Li-Peng Chen Dong-Ke Zhou Bai-Gao Yang Jia-Hua Zhang Yong-Ju Zhao Qiong-Hua Hong Yue-Hui Ma Ming-Xing Chu Lu-Pei Zhang Wang-Dui Basang Yan-Bin Zhu Yan-Guo Han Ri-Su Na Yan Zeng Zhong-Quan Zhao Yong-Fu Huang Han Jianlin livestock bovidae genes disease control animal diseases animal breeding Major histocompatibility complex (MHC) genes are critical for disease resistance or susceptibility responsible for host-pathogen interactions determined mainly by extensive polymorphisms in the MHC genes. Here, we examined the diversity and phylogenetic pattern of MHC haplotypes reconstructed using three MHC-linked microsatellite markers in 55 populations of five Bovidae species and compared them with those based on neutral autosomal microsatellite markers (NAMs). Three-hundred-and-forty MHC haplotypes were identified in 1453 Bovidae individuals, suggesting significantly higher polymorphism and heterozygosity compared with those based on NAMs. The ambitious boundaries in population differentiation (phylogenetic network, pairwise FST and STRUCTURE analyses) within and between species assessed using the MHC haplotypes were different from those revealed by NAMs associated closely with speciation, geographical distribution, domestication and management histories. In addition, the mean FST was significantly correlated negatively with the number of observed alleles (NA), observed (HO) and expected (HE) heterozygosity and polymorphism information content (PIC) (P < 0.05) in the MHC haplotype dataset while there was no correction of the mean FST estimates (P> 0.05) between the MHC haplotype and NAMs datasets. Analysis of molecular variance (AMOVA) revealed a lower percentage of total variance (PTV) between species/groups based on the MHC-linked microsatellites than NAMs. Therefore, it was inferred that individuals within populations accumulated as many MHC variants as possible to increase their heterozygosity and thus the survival rate of their affiliated populations and species, which eventually reduced population differentiation and thereby complicated their classification and phylogenetic relationship inference. In summary, host-pathogen coevolution and heterozygote advantage, rather than demographic history, act as key driving forces shaping the MHC diversity within the populations and determining the interspecific MHC diversity. 2020-08 2020-12-27T14:19:44Z 2020-12-27T14:19:44Z Journal Article https://hdl.handle.net/10568/110636 en Open Access Elsevier Guang-Xin, E., Li-Peng Chen, Dong-Ke Zhou, Bai-Gao Yang, Jia-Hua Zhang, Yong-Ju Zhao, Qiong-Hua Hong, Yue-Hui Ma, Ming-Xing Chu, Lu-Pei Zhang, Wang-Dui Basang, Yan-Bin Zhu, Yan-Guo Han, Ri-Su Na, Yan Zeng, Zhong-Quan Zhao, Yong-Fu Huang and Jian-Lin Han. 2020. Evolutionary relationship and population structure of domestic Bovidae animals based on MHC-linked and neutral autosomal microsatellite markers. Molecular Immunology 124:83-90. |
| spellingShingle | livestock bovidae genes disease control animal diseases animal breeding Guang-Xin, E. Li-Peng Chen Dong-Ke Zhou Bai-Gao Yang Jia-Hua Zhang Yong-Ju Zhao Qiong-Hua Hong Yue-Hui Ma Ming-Xing Chu Lu-Pei Zhang Wang-Dui Basang Yan-Bin Zhu Yan-Guo Han Ri-Su Na Yan Zeng Zhong-Quan Zhao Yong-Fu Huang Han Jianlin Evolutionary relationship and population structure of domestic Bovidae animals based on MHC-linked and neutral autosomal microsatellite markers |
| title | Evolutionary relationship and population structure of domestic Bovidae animals based on MHC-linked and neutral autosomal microsatellite markers |
| title_full | Evolutionary relationship and population structure of domestic Bovidae animals based on MHC-linked and neutral autosomal microsatellite markers |
| title_fullStr | Evolutionary relationship and population structure of domestic Bovidae animals based on MHC-linked and neutral autosomal microsatellite markers |
| title_full_unstemmed | Evolutionary relationship and population structure of domestic Bovidae animals based on MHC-linked and neutral autosomal microsatellite markers |
| title_short | Evolutionary relationship and population structure of domestic Bovidae animals based on MHC-linked and neutral autosomal microsatellite markers |
| title_sort | evolutionary relationship and population structure of domestic bovidae animals based on mhc linked and neutral autosomal microsatellite markers |
| topic | livestock bovidae genes disease control animal diseases animal breeding |
| url | https://hdl.handle.net/10568/110636 |
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