Determinants of vitamin D status in Kenyan calves
Vitamin D plays a critical role in calcium homeostasis and in the maintenance and development of skeletal health. Vitamin D status has increasingly been linked to non-skeletal health outcomes such as all-cause mortality, infectious diseases and reproductive outcomes in both humans and veterinary spe...
| Autores principales: | , , , , , |
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| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Springer
2020
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| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/110355 |
| _version_ | 1855519496481013760 |
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| author | Callaby, R. Hurst, E. Handel, Ian G. Toye, Philip G. Bronsvoort, B.M. de C. Mellanby, R.J. |
| author_browse | Bronsvoort, B.M. de C. Callaby, R. Handel, Ian G. Hurst, E. Mellanby, R.J. Toye, Philip G. |
| author_facet | Callaby, R. Hurst, E. Handel, Ian G. Toye, Philip G. Bronsvoort, B.M. de C. Mellanby, R.J. |
| author_sort | Callaby, R. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | Vitamin D plays a critical role in calcium homeostasis and in the maintenance and development of skeletal health. Vitamin D status has increasingly been linked to non-skeletal health outcomes such as all-cause mortality, infectious diseases and reproductive outcomes in both humans and veterinary species. We have previously demonstrated a relationship between vitamin D status, assessed by the measurement of serum concentrations of the major vitamin D metabolite 25 hydroxyvitamin D (25(OH)D), and a wide range of non-skeletal health outcomes in companion and wild animals. The aims of this study were to define the host and environmental factors associated with vitamin D status in a cohort of 527 calves from Western Kenya which were part of the Infectious Disease of East African Livestock (IDEAL) cohort. A secondary aim was to explore the relationship between serum 25(OH)D concentrations measured in 7-day old calves and subsequent health outcomes over the following 12 months. A genome wide association study demonstrated that both dietary and endogenously produced vitamin D metabolites were under polygenic control in African calves. In addition, we found that neonatal vitamin D status was not predictive of the subsequent development of an infectious disease event or mortality over the 12 month follow up period. |
| format | Journal Article |
| id | CGSpace110355 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Springer |
| publisherStr | Springer |
| record_format | dspace |
| spelling | CGSpace1103552024-05-01T08:16:03Z Determinants of vitamin D status in Kenyan calves Callaby, R. Hurst, E. Handel, Ian G. Toye, Philip G. Bronsvoort, B.M. de C. Mellanby, R.J. animal diseases animal health infectious diseases calves livestock Vitamin D plays a critical role in calcium homeostasis and in the maintenance and development of skeletal health. Vitamin D status has increasingly been linked to non-skeletal health outcomes such as all-cause mortality, infectious diseases and reproductive outcomes in both humans and veterinary species. We have previously demonstrated a relationship between vitamin D status, assessed by the measurement of serum concentrations of the major vitamin D metabolite 25 hydroxyvitamin D (25(OH)D), and a wide range of non-skeletal health outcomes in companion and wild animals. The aims of this study were to define the host and environmental factors associated with vitamin D status in a cohort of 527 calves from Western Kenya which were part of the Infectious Disease of East African Livestock (IDEAL) cohort. A secondary aim was to explore the relationship between serum 25(OH)D concentrations measured in 7-day old calves and subsequent health outcomes over the following 12 months. A genome wide association study demonstrated that both dietary and endogenously produced vitamin D metabolites were under polygenic control in African calves. In addition, we found that neonatal vitamin D status was not predictive of the subsequent development of an infectious disease event or mortality over the 12 month follow up period. 2020-11-25 2020-11-30T12:40:56Z 2020-11-30T12:40:56Z Journal Article https://hdl.handle.net/10568/110355 en Open Access Springer Callaby, R., Hurst, E., Handel, I., Toye, P., Bronsvoort, B.M. de C. and Mellanby, R.J. 2020. Determinants of vitamin D status in Kenyan calves. Scientific Reports 10:20590 |
| spellingShingle | animal diseases animal health infectious diseases calves livestock Callaby, R. Hurst, E. Handel, Ian G. Toye, Philip G. Bronsvoort, B.M. de C. Mellanby, R.J. Determinants of vitamin D status in Kenyan calves |
| title | Determinants of vitamin D status in Kenyan calves |
| title_full | Determinants of vitamin D status in Kenyan calves |
| title_fullStr | Determinants of vitamin D status in Kenyan calves |
| title_full_unstemmed | Determinants of vitamin D status in Kenyan calves |
| title_short | Determinants of vitamin D status in Kenyan calves |
| title_sort | determinants of vitamin d status in kenyan calves |
| topic | animal diseases animal health infectious diseases calves livestock |
| url | https://hdl.handle.net/10568/110355 |
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