Historical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep
How animals, particularly livestock, adapt to various climates and environments over short evolutionary time is of fundamental biological interest. Further, understanding the genetic mechanisms of adaptation in indigenous livestock populations is important for designing appropriate breeding programs...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | Inglés |
| Published: |
Oxford University Press
2021
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10568/110111 |
| _version_ | 1855543300047503360 |
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| author | Yin-Hong Cao Song-Song Xu Min Shen Ze-Hui Chen Lei Gao Feng-Hua Lv Xing-Long Xie Xin-Hua Wang Hua Yang Chang-Bin Liu Ping Zhou Peng-Cheng Wan Yun-Sheng Zhang Jing-Quan Yang Wen-Hui Pi Eer Hehua Berry, D.P. Barbato, M. Esmailizadeh, A. Nosrati, M. Salehian-Dehkordi, H. Dehghani-Qanatqestani, M. Dotsev, A.V. Deniskova, T.E. Zinovieva, N.A. Brem, G. Štěpánek, O. Ciani, E. Weimann, C. Erhardt, G. Mwacharo, Joram M. Ahbara, A. Han Jianlin Hanotte, Olivier H. Miller, J.M. Sim, Z. Zijian Sim Coltman, D. Kantanen, J. Bruford, M.W. Lenstra, J.A. Kijas, J. Meng-Hua Li |
| author_browse | Ahbara, A. Barbato, M. Berry, D.P. Brem, G. Bruford, M.W. Chang-Bin Liu Ciani, E. Coltman, D. Dehghani-Qanatqestani, M. Deniskova, T.E. Dotsev, A.V. Eer Hehua Erhardt, G. Esmailizadeh, A. Feng-Hua Lv Han Jianlin Hanotte, Olivier H. Hua Yang Jing-Quan Yang Kantanen, J. Kijas, J. Lei Gao Lenstra, J.A. Meng-Hua Li Miller, J.M. Min Shen Mwacharo, Joram M. Nosrati, M. Peng-Cheng Wan Ping Zhou Salehian-Dehkordi, H. Sim, Z. Song-Song Xu Weimann, C. Wen-Hui Pi Xin-Hua Wang Xing-Long Xie Yin-Hong Cao Yun-Sheng Zhang Ze-Hui Chen Zijian Sim Zinovieva, N.A. Štěpánek, O. |
| author_facet | Yin-Hong Cao Song-Song Xu Min Shen Ze-Hui Chen Lei Gao Feng-Hua Lv Xing-Long Xie Xin-Hua Wang Hua Yang Chang-Bin Liu Ping Zhou Peng-Cheng Wan Yun-Sheng Zhang Jing-Quan Yang Wen-Hui Pi Eer Hehua Berry, D.P. Barbato, M. Esmailizadeh, A. Nosrati, M. Salehian-Dehkordi, H. Dehghani-Qanatqestani, M. Dotsev, A.V. Deniskova, T.E. Zinovieva, N.A. Brem, G. Štěpánek, O. Ciani, E. Weimann, C. Erhardt, G. Mwacharo, Joram M. Ahbara, A. Han Jianlin Hanotte, Olivier H. Miller, J.M. Sim, Z. Zijian Sim Coltman, D. Kantanen, J. Bruford, M.W. Lenstra, J.A. Kijas, J. Meng-Hua Li |
| author_sort | Yin-Hong Cao |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | How animals, particularly livestock, adapt to various climates and environments over short evolutionary time is of fundamental biological interest. Further, understanding the genetic mechanisms of adaptation in indigenous livestock populations is important for designing appropriate breeding programs to cope with the impacts of changing climate. Here, we conducted a comprehensive genomic analysis of diversity, interspecies introgression, and climate-mediated selective signatures in a global sample of sheep and their wild relatives. By examining 600K and 50K genome-wide single nucleotide polymorphism data from 3,447 samples representing 111 domestic sheep populations and 403 samples from all their seven wild relatives (argali, Asiatic mouflon, European mouflon, urial, snow sheep, bighorn, and thinhorn sheep), coupled with 88 whole-genome sequences, we detected clear signals of common introgression from wild relatives into sympatric domestic populations, thereby increasing their genomic diversities. The introgressions provided beneficial genetic variants in native populations, which were significantly associated with local climatic adaptation. We observed common introgression signals of alleles in olfactory-related genes (e.g., ADCY3 and TRPV1) and the PADI gene family including in particular PADI2, which is associated with antibacterial innate immunity. Further analyses of whole-genome sequences showed that the introgressed alleles in a specific region of PADI2 (chr2: 248,302,667–248,306,614) correlate with resistance to pneumonia. We conclude that wild introgression enhanced climatic adaptation and resistance to pneumonia in sheep. This has enabled them to adapt to varying climatic and environmental conditions after domestication. |
| format | Journal Article |
| id | CGSpace110111 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2021 |
| publishDateRange | 2021 |
| publishDateSort | 2021 |
| publisher | Oxford University Press |
| publisherStr | Oxford University Press |
| record_format | dspace |
| spelling | CGSpace1101112025-12-08T09:54:28Z Historical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep Yin-Hong Cao Song-Song Xu Min Shen Ze-Hui Chen Lei Gao Feng-Hua Lv Xing-Long Xie Xin-Hua Wang Hua Yang Chang-Bin Liu Ping Zhou Peng-Cheng Wan Yun-Sheng Zhang Jing-Quan Yang Wen-Hui Pi Eer Hehua Berry, D.P. Barbato, M. Esmailizadeh, A. Nosrati, M. Salehian-Dehkordi, H. Dehghani-Qanatqestani, M. Dotsev, A.V. Deniskova, T.E. Zinovieva, N.A. Brem, G. Štěpánek, O. Ciani, E. Weimann, C. Erhardt, G. Mwacharo, Joram M. Ahbara, A. Han Jianlin Hanotte, Olivier H. Miller, J.M. Sim, Z. Zijian Sim Coltman, D. Kantanen, J. Bruford, M.W. Lenstra, J.A. Kijas, J. Meng-Hua Li sheep climate change animal breeding livestock indigenous breeds How animals, particularly livestock, adapt to various climates and environments over short evolutionary time is of fundamental biological interest. Further, understanding the genetic mechanisms of adaptation in indigenous livestock populations is important for designing appropriate breeding programs to cope with the impacts of changing climate. Here, we conducted a comprehensive genomic analysis of diversity, interspecies introgression, and climate-mediated selective signatures in a global sample of sheep and their wild relatives. By examining 600K and 50K genome-wide single nucleotide polymorphism data from 3,447 samples representing 111 domestic sheep populations and 403 samples from all their seven wild relatives (argali, Asiatic mouflon, European mouflon, urial, snow sheep, bighorn, and thinhorn sheep), coupled with 88 whole-genome sequences, we detected clear signals of common introgression from wild relatives into sympatric domestic populations, thereby increasing their genomic diversities. The introgressions provided beneficial genetic variants in native populations, which were significantly associated with local climatic adaptation. We observed common introgression signals of alleles in olfactory-related genes (e.g., ADCY3 and TRPV1) and the PADI gene family including in particular PADI2, which is associated with antibacterial innate immunity. Further analyses of whole-genome sequences showed that the introgressed alleles in a specific region of PADI2 (chr2: 248,302,667–248,306,614) correlate with resistance to pneumonia. We conclude that wild introgression enhanced climatic adaptation and resistance to pneumonia in sheep. This has enabled them to adapt to varying climatic and environmental conditions after domestication. 2021-03-09 2020-11-10T13:56:13Z 2020-11-10T13:56:13Z Journal Article https://hdl.handle.net/10568/110111 en Open Access Oxford University Press Yin-Hong Cao, Song-Song Xu, Min Shen, Ze-Hui Chen, Lei Gao, Feng-Hua Lv, Xing-Long Xie, Xin-Hua Wang, Hua Yang, Chang-Bin Liu, Ping Zhou, Peng-Cheng Wan, Yun-Sheng Zhang, Jing-Quan Yang, Wen-Hui Pi, EEr, H., Berry, D.P., Barbato, M., Esmailizadeh, A., Nosrati, M., Salehian-Dehkordi, H., Dehghani-Qanatqestani, M., Dotsev, A.V., Deniskova, T.E., Zinovieva, N.A., Brem, G., Štěpánek, O., Ciani, E., Weimann, C., Erhardt, G., Mwacharo, J.M., Ahbara, A., Han Jianlin, Hanotte, O.H., Miller, J.M., Zijian Sim, Coltman, D., Kantanen, J., Bruford, M.W., Lenstra, J.A., Kijas, J., Meng-Hua Li. 2020. Historical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep. Molecular Biology and Evolution |
| spellingShingle | sheep climate change animal breeding livestock indigenous breeds Yin-Hong Cao Song-Song Xu Min Shen Ze-Hui Chen Lei Gao Feng-Hua Lv Xing-Long Xie Xin-Hua Wang Hua Yang Chang-Bin Liu Ping Zhou Peng-Cheng Wan Yun-Sheng Zhang Jing-Quan Yang Wen-Hui Pi Eer Hehua Berry, D.P. Barbato, M. Esmailizadeh, A. Nosrati, M. Salehian-Dehkordi, H. Dehghani-Qanatqestani, M. Dotsev, A.V. Deniskova, T.E. Zinovieva, N.A. Brem, G. Štěpánek, O. Ciani, E. Weimann, C. Erhardt, G. Mwacharo, Joram M. Ahbara, A. Han Jianlin Hanotte, Olivier H. Miller, J.M. Sim, Z. Zijian Sim Coltman, D. Kantanen, J. Bruford, M.W. Lenstra, J.A. Kijas, J. Meng-Hua Li Historical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep |
| title | Historical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep |
| title_full | Historical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep |
| title_fullStr | Historical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep |
| title_full_unstemmed | Historical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep |
| title_short | Historical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep |
| title_sort | historical introgression from wild relatives enhanced climatic adaptation and resistance to pneumonia in sheep |
| topic | sheep climate change animal breeding livestock indigenous breeds |
| url | https://hdl.handle.net/10568/110111 |
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