Inverted CD4 +/CD8 + T cell ratio in Boran (Bos indicus) cattle
The CD4+/CD8+ ratio is used as a marker of the immune regulation of T cell balance. When the ratio in peripheral blood is less than 1, this is considered an indication of immune suppression in an individual. Previous work on bovine Peripheral Blood Mononuclear Cells (PBMC) has consistently reported...
| Autores principales: | , , , , , , , , , |
|---|---|
| Formato: | Journal Article |
| Lenguaje: | Inglés |
| Publicado: |
Elsevier
2020
|
| Materias: | |
| Acceso en línea: | https://hdl.handle.net/10568/109941 |
| _version_ | 1855528956307963904 |
|---|---|
| author | Makau, Maurine C. Powell, Jessica Prendergast, James G.D. Latré de Laté, Perle Morrison, Liam J. Fisch, Andressa Gathura, Peter Kitala, Phillip Connelley, Timothy Toye, Philip G. |
| author_browse | Connelley, Timothy Fisch, Andressa Gathura, Peter Kitala, Phillip Latré de Laté, Perle Makau, Maurine C. Morrison, Liam J. Powell, Jessica Prendergast, James G.D. Toye, Philip G. |
| author_facet | Makau, Maurine C. Powell, Jessica Prendergast, James G.D. Latré de Laté, Perle Morrison, Liam J. Fisch, Andressa Gathura, Peter Kitala, Phillip Connelley, Timothy Toye, Philip G. |
| author_sort | Makau, Maurine C. |
| collection | Repository of Agricultural Research Outputs (CGSpace) |
| description | The CD4+/CD8+ ratio is used as a marker of the immune regulation of T cell balance. When the ratio in peripheral blood is less than 1, this is considered an indication of immune suppression in an individual. Previous work on bovine Peripheral Blood Mononuclear Cells (PBMC) has consistently reported a ratio ≥1 as seen in other mammalian hosts, i.e. higher circulating CD4+ cell numbers than CD8+ cell numbers. However, a consistent inverted CD4+/CD8+ ratio (<1) was observed in Boran cattle, an African Bos indicus breed. The T cell populations were characterized in Boran cattle (n = 52), revealing higher percentages of circulating CD8+ cells (31.9 % average) than CD4+ cells (19.1 % average), thus resulting in the inversion of the expected T cell homeostasis in these animals. The results show that this inversion is not an effect of age or relatedness of the cattle, rather, it was shared by almost all Boran cattle used in this study. Despite this inversion being a feature shared by both males and females, the female cattle had significantly higher CD4+/CD8+ ratios than the male Boran. This paper describes the characteristics of the T cell fractions in the study animals and compares the findings to those of other Boran cattle in Kenya, and four other cattle breeds representing African indicine, African taurine, Brazilian indicine and European taurine cattle. We demonstrate that the consistent observation of inverted CD4+/CD8+ cell ratio was restricted to the Boran. |
| format | Journal Article |
| id | CGSpace109941 |
| institution | CGIAR Consortium |
| language | Inglés |
| publishDate | 2020 |
| publishDateRange | 2020 |
| publishDateSort | 2020 |
| publisher | Elsevier |
| publisherStr | Elsevier |
| record_format | dspace |
| spelling | CGSpace1099412025-09-25T13:01:42Z Inverted CD4 +/CD8 + T cell ratio in Boran (Bos indicus) cattle Makau, Maurine C. Powell, Jessica Prendergast, James G.D. Latré de Laté, Perle Morrison, Liam J. Fisch, Andressa Gathura, Peter Kitala, Phillip Connelley, Timothy Toye, Philip G. cattle livestock animal diseases The CD4+/CD8+ ratio is used as a marker of the immune regulation of T cell balance. When the ratio in peripheral blood is less than 1, this is considered an indication of immune suppression in an individual. Previous work on bovine Peripheral Blood Mononuclear Cells (PBMC) has consistently reported a ratio ≥1 as seen in other mammalian hosts, i.e. higher circulating CD4+ cell numbers than CD8+ cell numbers. However, a consistent inverted CD4+/CD8+ ratio (<1) was observed in Boran cattle, an African Bos indicus breed. The T cell populations were characterized in Boran cattle (n = 52), revealing higher percentages of circulating CD8+ cells (31.9 % average) than CD4+ cells (19.1 % average), thus resulting in the inversion of the expected T cell homeostasis in these animals. The results show that this inversion is not an effect of age or relatedness of the cattle, rather, it was shared by almost all Boran cattle used in this study. Despite this inversion being a feature shared by both males and females, the female cattle had significantly higher CD4+/CD8+ ratios than the male Boran. This paper describes the characteristics of the T cell fractions in the study animals and compares the findings to those of other Boran cattle in Kenya, and four other cattle breeds representing African indicine, African taurine, Brazilian indicine and European taurine cattle. We demonstrate that the consistent observation of inverted CD4+/CD8+ cell ratio was restricted to the Boran. 2020-12 2020-10-22T15:52:30Z 2020-10-22T15:52:30Z Journal Article https://hdl.handle.net/10568/109941 en Open Access Elsevier Makau, M.C., Powell, J., Prendergast, J., Laté, P.L. de, Morrison, L.J., Fisch, A., Gathura, P., Kitala, P., Connelley, T. and Toye, P. 2020. Inverted CD4 +/CD8 + T cell ratio in Boran (Bos indicus) cattle. Veterinary Immunology and Immunopathology 230:110126. |
| spellingShingle | cattle livestock animal diseases Makau, Maurine C. Powell, Jessica Prendergast, James G.D. Latré de Laté, Perle Morrison, Liam J. Fisch, Andressa Gathura, Peter Kitala, Phillip Connelley, Timothy Toye, Philip G. Inverted CD4 +/CD8 + T cell ratio in Boran (Bos indicus) cattle |
| title | Inverted CD4 +/CD8 + T cell ratio in Boran (Bos indicus) cattle |
| title_full | Inverted CD4 +/CD8 + T cell ratio in Boran (Bos indicus) cattle |
| title_fullStr | Inverted CD4 +/CD8 + T cell ratio in Boran (Bos indicus) cattle |
| title_full_unstemmed | Inverted CD4 +/CD8 + T cell ratio in Boran (Bos indicus) cattle |
| title_short | Inverted CD4 +/CD8 + T cell ratio in Boran (Bos indicus) cattle |
| title_sort | inverted cd4 cd8 t cell ratio in boran bos indicus cattle |
| topic | cattle livestock animal diseases |
| url | https://hdl.handle.net/10568/109941 |
| work_keys_str_mv | AT makaumaurinec invertedcd4cd8tcellratioinboranbosindicuscattle AT powelljessica invertedcd4cd8tcellratioinboranbosindicuscattle AT prendergastjamesgd invertedcd4cd8tcellratioinboranbosindicuscattle AT latredelateperle invertedcd4cd8tcellratioinboranbosindicuscattle AT morrisonliamj invertedcd4cd8tcellratioinboranbosindicuscattle AT fischandressa invertedcd4cd8tcellratioinboranbosindicuscattle AT gathurapeter invertedcd4cd8tcellratioinboranbosindicuscattle AT kitalaphillip invertedcd4cd8tcellratioinboranbosindicuscattle AT connelleytimothy invertedcd4cd8tcellratioinboranbosindicuscattle AT toyephilipg invertedcd4cd8tcellratioinboranbosindicuscattle |